Medicinal Plants, against Dental associated Problems

Nistane, Neha T.; Chauriya, Chandrashekhar B; Bangade, Rahul

doi:10.5958/0975-4377.2019.00002.8

Rese. Jour. Pharmaceut. Dosag. Form. and Technol.

2019

DOI: 10.5958/0975-4377.2019.00002.8

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Medicinal Plants, against Dental associated Problems

Neha T. Nistane¹,

Chandrashekhar B Chauriya²,

Rahul Bangade³

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Cited by 6 publications

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“…16,17 Herbal medicines from plants represent an important source of medical compounds and have been observed as therapeutic agents able to cure several types of health problems. [18][19][20] Chrysophyllum cainito L.…”

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confidence: 99%

Effect of Chrysophyllum cainito L. Leaves on Bone Formation In Vivo and In Silico

2021

TJNPR

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Osteoporosis is a condition where bone mass degradation occurs. The condition causes bone microarchitecture damage, which can increase the risk of fractures. 1,2,3 Prevalence of osteoporosis reached 36 million by 2013. 4 Osteoporosis is usually experienced by postmenopausal women, who are suffering from estrogen deficiency and affects the balance of the bone remodelling process. 5,6 The treatment considered suitable for patients with estrogen deficiency induced-osteoporosis was hormone replacement therapy (HRT). However, long-term therapy of HRT may lead to several side effects and higher costs, such as stroke, breast cancer, coronary events, dementia, and venous thromboembolism. [6][7][8][9][10] Phytoestrogens are plant compounds that have estrogen-like functions or structures. It can replace the estrogen in its bond with estrogen receptors (ERs) as phytoestrogens can substitute the receptors. 11,12 Phytoestrogens are known to have no side effect and have acted for the treatment of estrogen deficiency induced-diseases, 13,14,15 such as osteoporosis. 16 Plants are a source of many potent and powerful drugs. Plants with healing properties are medicinal plants or herbs. 16,17 Herbal medicines from plants represent an important source of medical compounds and have been observed as therapeutic agents able to cure several types of health problems. [18][19][20] Chrysophyllum cainito L.

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confidence: 99%

Effect of Chrysophyllum cainito L. Leaves on Bone Formation In Vivo and In Silico

2021

TJNPR

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In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

Zeenat,

Prajapati,

Sangeet

et al. 2023

RJPT

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Background: Staphylococcus aureus is a threat to human health, it colonizes one-third of the human population via skin or nose and deeper intrusions into tissues have catastrophic consequences. The bacterium secretes virulence proteins like CHIP and SCIN and extracellular adhesins like extracellular adherence (Eap) proteins. Eap and its functionally orphan homologs, EapH1 and EapH2; are a class of secreted proteins that inhibit neutrophil serine proteases such as neutrophil elastase (HNE) that is linked to tissue degradation in a variety of disease conditions including inflammatory disorders. Commercial drugs used against S.aureus such as Nafcillin, Pefloxacin, etc. have been known to have negative effects and are not recommended for children, the elderly, or pregnant women. Objective: The current research focuses on discovering phytochemicals found in Indian medicinal herbs that have been used as spices for ages and are already beneficial against a variety of illnesses and ailments to be used against Eap proteins. Method: Molecular docking;absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis and Simulation were performed to see if these phytochemicals interact with the active site residues of Eap proteins and function as competitive inhibitors of NE and to know their drug like properties and gather information about the system dynamics. 19 phytochemicals were selected from receptor-ligand docking. The selected molecules were pharmacologically tested through Lipinski’s analysis; to know their ability for being formulated into drugs. ADMET analysis was carried out to define the biological characteristic of phytochemicals inside the living body. The phytochemicals with the best docking score and drug likeliness were analysed by Molecular Simulation to observe the fluctuation of participating and interacting amino acids with Eaph1 and Eaph2 respectively. Result: Among the nineteen phytochemicals that were chosen for docking only the best eleven interactions were chosen for ADMET analysis. The top hit phytochemicals for Eaph1 and Eaph2 were Curcumin and Eugenol respectively, which was well demonstrated by Molecular dynamic simulation. Conclusion: The present study has established the hypothesis that phytochemicals have a scope to replace commercial drugs against the Eap virulence system of Staphylococcus aureus

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Glycerine addition in Cashew stembark extract mouthwash influence the inhibition of bacterial growth

Harsini,

Irnawati,

Anindya Widyasrini

et al. 2024

RJPT

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The part of cashew plant (Anacardium Occidentale Linn) can be utilized as an ingredient in herbal medicine. Alkaloids, tannins, and flavonoids found in cashew stembark exhibit broad-spectrum antibacterial activity, making them appropriate as an active ingredient in mouthwash. On the other hand, one of the key ingredients in mouthwash formulas is glycerin. It is also frequently used as humectant. This study aims to prove the effect of glycerin on the cashew stembark extract mouthwash on its antibacterial activity. This study used 4 formulas consisted of 7% concentration of cashew stembark extract added with 1% sorbitol, 1.5% peppermint, distilled water as solvent, and various concentration of glycerin for each formula. The clarity, color change, and taste were assessed at day 7. The growth inhibition of both gram positive (S. aureus) and gram negative (P. aeruginosa) bacteria was measured. The data obtained were tested using one-way ANOVA and LSD (α=0.05). All of the 4 formulas of the mouthwashes found to be relatively stable. Based on the results of the inhibition test, it can be concluded that the addition of glycerin affects the inhibition of S. aureus and P. aeruginosa bacteria. Glycerin had significant effect on bacterial growth inhibition at 15% (Formula III).

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Medicinal Plants, against Dental associated Problems

Cited by 6 publications

References 0 publications

Effect of Chrysophyllum cainito L. Leaves on Bone Formation In Vivo and In Silico

Effect of Chrysophyllum cainito L. Leaves on Bone Formation In Vivo and In Silico

In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

Glycerine addition in Cashew stembark extract mouthwash influence the inhibition of bacterial growth

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