Medicinal plants and finished marketed herbal products used in the treatment of malaria in the Ashanti region, Ghana

Komlaga, Gustav; Agyare, Christian; Dickson, Rita A.; Mensah, Merlin Lincoln Kwao; Annan, Kofi; Loiseau, Philippe M.; Champy, Pierre

doi:10.1016/j.jep.2015.06.041

Cited by 88 publications

(52 citation statements)

References 76 publications

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“…In this study, the leachates of Carica papaya, Momordica charantia, Azadirachta indica, Alstonia boonei, Spathodea campanulata, Ficus exasperata, Phyllanthus urinaria, Eclipta alba, Cleistopholis patens, and Kalanchoe integra showed inhibitory effects on lettuce radicle (67-86%). These medicinal species were also of high importance based on their reported ethnobotanical indices reported in this study area and also in other studies [69,75,76,99,102,108,119,126]. It can be inferred from these highly significant positive correlations that the bioactive substances associated with curative effects of the understudied medicinal plants may play a role in the allelopathy of such species.…”

Section: Correlation Between Ethnobotanical Indices and Allelopathic supporting

confidence: 79%

“…Similarly, Tectona grandis (FL = 100%) is utilised in other parts of Ghana [77,99], Nigeria [100], and Cote d'Ivoire [101] for the treatment of malaria. In addition, Cleistopholis patens is used to treat malaria in other areas of Ghana [77,102] and Cameroon [103]. Vernonia amygdalina (FL = 65%) is highly preferred in Uganda for the treatment of malaria, stomach ache, and convulsions [75] and for managing impotence, dandruff and bloating in Ethiopia [87].…”

Section: Comparison Of Documented Data On Medicinal Plants With Previmentioning

confidence: 99%

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Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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This paper presents the first application of ethnobotanical studies to screen for allelopathic species among medicinal plants for sustainable weed management. This study assesses the possible relationship between ethnobotanical indices and allelopathy of medicinal plants. Ethnobotanical data were collected in 2016 by using semi-structured interviews with 140 informants in the Ejisu-Juaben Municipality, Ghana. Data were analysed using statistical tool and ethnobotanical indices including use value (UV), Fidelity Level (FL), Relative Frequency of Citation (RFC). The Sandwich and Dish pack methods were respectively used to evaluate allelopathy through leachates and volatiles of collected samples. Ninety-five species belonging to 43 families are reported in this study, with leaves (52%) cited the most utilised plant part. Cleistopholis patens (UV = 0.54; FL = 90.7%; RFC = 0.37) and Ocimum gratissimum (UV = 0.37; FL = 38.4%; RFC = 0.35) were among the most cited species. Thirty-two species showed inhibition (≥49.3%) by leachates, while twenty-four species were found with potential volatile inhibitory compounds against lettuce radicle growth. There was a significant positive correlation (Pearson) between the UV and RFC of medicinal plants and allelopathy by leaf leachates (r = 0.639 **; p = 0.01 and r = 0.653 **; p = 0.01 respectively). This systematic documentation of medicinal plants in Ejisu-Juaben Municipality shows medicinal plants with ethnomedicinal values and potential allelopathy that can be utilised in sustainable weed control.

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Section: Correlation Between Ethnobotanical Indices and Allelopathic supporting

confidence: 79%

Section: Comparison Of Documented Data On Medicinal Plants With Previmentioning

confidence: 99%

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

et al. 2017

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“…Similarly, Momordica charantia, a known anti-diabetic and antimalarial plant but also used in Ghana as an abortifacient [21,22], has reportedly caused deadly hypoglycemia in children [23].…”

Section: Herbal Medicinementioning

confidence: 99%

“…For example, Barbosa et al [25] reported clinical and pathological neurological disorders in horses following a large intake of fresh Bambusa vulgaris leaves. Paradoxically, the aqueous decoction is a popular antimalarial medicine in Ghana [11,21] and this has been used without any report of adverse reaction. Besides, the aqueous extract of the leaves did not cause cytotoxicity in normal human cells [11,21].…”

Section: Safety Of Medicinal Plants and Herbal Medicines Used In Tradmentioning

confidence: 99%

Toxicity and Safety Implications of Herbal Medicines Used in Africa

Mensah¹,

Komlaga²,

Forkuo³

et al. 2019

Herbal Medicine

Self Cite

109

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The use of herbal medicines has seen a great upsurge globally. In developing countries, many patronize them largely due to cultural acceptability, availability and cost. In developed countries, they are used because they are natural and therefore assumed to be safer than allopathic medicines. In recent times, however, there has been a growing concern about their safety. This has created a situation of ambivalence in discussions regarding their use. Some medicinal plants are intrinsically toxic by virtue of their constituents and can cause adverse reactions if inappropriately used. Other factors such as herb-drug interactions, lack of adherence to good manufacturing practice (GMP), poor regulatory measures and adulteration may also lead to adverse events in their use. Many in vivo tests on aqueous extracts largely support the safety of herbal medicines, whereas most in vitro tests on isolated single cells mostly with extracts other than aqueous ones show contrary results and thus continue the debate on herbal medicine safety. It is expected that toxicity studies concerning herbal medicine should reflect their traditional use to allow for rational discussions regarding their safety for their beneficial use. While various attempts continue to establish the safety of various herbal medicines in man, their cautious and responsible use is required.

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“…Ethnobotanical and ethnopharmacological studies reported that at least one bromeliad species is commonly used by several communities and ethnic groups to treat diseases (Agra, Baracho, Nurit, Basílio, & Coelho, 2007;Albertasse, Thomaz, & Andrade, 2010;De Almeida, Rangel, Ramos, & Silva, 2011;Bieski et al, 2012;de Feo & Soria, 2012;Juárez-Vázquez et al, 2013;Kujawska, Zamudio, & Hilgert, 2012;Nunes et al, 2015;Sreekeesoon & Mahomoodally, 2014). Some other bromeliad species that are important in traditional knowledge include Bromelia serra (Bourdy et al, 2004), Ananas ananassoides (Coelho-Ferreira, 2009), Encholirium spectabile (Oliveira, Barros, & Moita Neto, 2010), Ananas comosus (Bieski et al, 2015;Komlaga et al, 2015), and Ananas bracteatus (Samoisy & Mahomoodally, 2016). Some other bromeliad species that are important in traditional knowledge include Bromelia serra (Bourdy et al, 2004), Ananas ananassoides (Coelho-Ferreira, 2009), Encholirium spectabile (Oliveira, Barros, & Moita Neto, 2010), Ananas comosus (Bieski et al, 2015;Komlaga et al, 2015), and Ananas bracteatus (Samoisy & Mahomoodally, 2016).…”

Section: Traditional Knowledgementioning

confidence: 99%

Ecosystem services provided by bromeliad plants: A systematic review

Ladino

Bautista

Varón

et al. 2019

Ecology and Evolution

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The unprecedented loss of biological diversity has negative impacts on ecosystems and the associated benefits which they provide to humans. Bromeliads have high diversity throughout the Neotropics, but they have been negatively affected by habitat loss and fragmentation, climate change, invasive species, and commercialization for ornamental purpose. These plants provide direct benefits to the human society, and they also form microecosystems in which accumulated water and nutrients support the communities of aquatic and terrestrial species, thus maintaining local diversity. We performed a systematic review of the contribution of bromeliads to ecosystem services across their native geographical distribution. We showed that bromeliads provide a range of ecosystem services such as maintenance of biodiversity, community structure, nutrient cycling, and the provisioning of food and water. Moreover, bromeliads can regulate the spread of diseases, and water and carbon cycling, and they have the potential to become important sources of chemical and pharmaceutical products. The majority of this research was performed in Brazil, but future research from other Neotropical countries with a high diversity of bromeliads would fill the current knowledge gaps and increase the generality of these findings. This systematic review identified that future research should focus on provisioning, regulating, and cultural services that have been currently overlooked. This would enhance our understanding of how bromeliad diversity contributes to human welfare, and the negative consequences that loss of bromeliad plants can have on communities of other species and the healthy functioning of the entire ecosystems.

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Medicinal plants and finished marketed herbal products used in the treatment of malaria in the Ashanti region, Ghana

Cited by 88 publications

References 76 publications

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Exploring Alternative Use of Medicinal Plants for Sustainable Weed Management

Toxicity and Safety Implications of Herbal Medicines Used in Africa

Ecosystem services provided by bromeliad plants: A systematic review

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