Medicinal Plants and Natural Products with Demonstrated Wound Healing Properties

Abstract

This section reviews the current literature on medicinal plants including extracts, fractions, isolated compounds and natural products that have been demonstrated to have wound healing properties. Various electronic databases such as PubMed, Science Direct, SciFinder and Google Scholar were employed to search for plants, natural plant constituents and natural products that have been scientifically demonstrated to have wound healing activity using in vivo and in vitro wound models. Parameters used in the evaluation of an agent with wound healing properties include rate of wound contraction, tensile strength, antioxidant and antimicrobial activities, hydroxyproline content assay and histological investigations including re-epithelization, collagen synthesis, granulation, proliferation and differentiation of fibroblasts and keratinocytes in excision and incision wound model studies. Eighty-five medicinal plants belonging to 45 families, phytoconstituents including phenolics, oils and other substances including honey were identified as potential wound healing agents or possess wound healing properties using various wound healing models.

"Evaluate the efficacy of Antimicrobial activity of aqueous extract of Nigella Sativa seeds powder on Staphylococcus Aureus"

“…The mean inhibitory zones for the hot extract were displayed a statistically significant difference (p=0.00, p<0.05) with each concentration. There was no significant difference between the Nigella sativa hot and cold extract at a concentration of 10mg/10ml against Staphylococcus aureus [14][15][16][17][18][19].…”

Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades

“…Changing the timing or levels of these important compounds can change the balance of the cocktail of compounds controlling the body’s response to a wound. This critical role has meant a group of traditional medicines that alter the balance of cytokines and growth factors used specifically for wound healing [ 97 ].…”

“…There are countless herbs and plant extracts used in the many different cultures worldwide as wound-healing medicines. A more comprehensive list was compiled by Agyare et al, which lists many compounds less studied and not discussed in this review [ 97 ].…”

Phytochemical composition of Verbascum stachydifolium Boiss & Heldr. var. stachydifolium growing in Türkiye and in vitro analysis of wound healing activity

“…About 60% of the world's population and 60-90% of the human population in developing countries use traditional medicinal plants in primary health care [1]. In recent years, there has been an increase in the use of herbal and natural products in the management and treatment of various disease states among people in developed countries, including the US, Europe, and Japan.…”