Medicinal Plants and Phytochemicals as Neuroprotective Agents in the Treatment of Neurodegenerative Diseases

Gezici, Sevgi; KOÇUM, Didem

doi:10.46810/tdfd.977356

Cited by 3 publications

(1 citation statement)

References 81 publications

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“…Medicinal plants and phytochemicals are used against neurodegenerative diseases [14]. Herbal substances are used because of their therapeutic properties against various toxicants [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

AKARSU,

ÇETİN

2023

Türk Doğa Ve Fen Dergisi

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Alzheimer's disease affects all tissues negatively. In this study, it was aimed to determine the effects of TQ on testicular toxicity in rats with experimental Alzheimer's disease. In the study, 33 Wistar Albino rats weighing 190-230 gr were used. Rats were 11 rats in each group; were divided into 3 equal groups as control, ALZ and ALZ+TQ. The control group was given saline by IP route for 28 days daily. The ALZ group was given 60 mg/kg D-gal + 40 mg/kg AlCl3 IP for 28 days daily. The ALZ+TQ group was given 60 mg/kg D-gal + 40mg/kg AlCl3 for 28 days by IP + 20 mg/kg TQ by oral gavage for last 14 days daily. According to the findings of our study, a decrease in SOD, CAT, GPx activity and GSH levels and an increase in MDA levels were determined in the ALZ group. In the ALZ+TQ group, while SOD, GPx, CAT activities and GSH levels increased, MDA levels decreased. Semen analyzes showed that there was a decrease in sperm motility and sperm density in the ALZ group, and an increase in the rate of abnormal sperm and dead spermatozoa. In the ALZ+TQ group, sperm motility, abnormal sperm rate and dead spermatozon rate improved. As a result, it was determined that the decrease in semen quality and increase in oxidative stress induced by AlCl3+D-Gal were suppressed by TQ, protecting the testicular tissue from oxidative damage and increasing semen quality.

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Section: Introductionmentioning

confidence: 99%

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

AKARSU,

ÇETİN

2023

Türk Doğa Ve Fen Dergisi

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Herbal Drugs for Oxidative Stress in Developmental Brain Disorders

Bati

2024

Brain Health and Medicinal Plants

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In summary, neurodegenerative diseases are multifactorial disorders marked by the degeneration and eventual death of nerve cells, leading to structural and functional deterioration. Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis are notable examples of such diseases, impacting quality of life and often progressing rapidly. While there is currently no definitive cure for these conditions, treatment strategies focus on enhancing quality of life by slowing disease progression. However, chronic use of existing therapeutic interventions and medications can cause serious side effects. This situation has led patients to turn to alternative medicine practices.A prominent approach among complementary medicine practices is the use of medicinal plants with neuroprotective properties. These plants can aid in brain injury recovery and enhance learning and memory functions through the stimulation of new synapse formation. These plants containing phytochemicals may be effective in the developmental mechanisms of neurodegenerative diseases and may favourably affect the prognosis of the disease. Therefore, phytochemical, pharmacological and clinical research on medicinal plants may make promising contributions to the development of naturally derived drugs for neurodegenerative diseases.

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Chemical and Biologic Contaminated Medicinal Plants and Brain Health

Koc

2024

Brain Health and Medicinal Plants

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Humans need medicinal plants to continue their lives in a healthy way. This need will continue in the past, present, and future. The earth can be polluted naturally or by human sources. Medicinal plants consumed by humans for various purposes can be affected by this pollution. One of the important points that people should pay attention to is the use of medicinal plants without biological and chemical contamination. In this compiled book chapter, scientific studies on chemically and biologically contaminated medicinal plants and brain health are included. The current study is original and is expected to contribute to those interested in the subject.

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Medicinal Plants and Phytochemicals as Neuroprotective Agents in the Treatment of Neurodegenerative Diseases

Cited by 3 publications

References 81 publications

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Herbal Drugs for Oxidative Stress in Developmental Brain Disorders

Chemical and Biologic Contaminated Medicinal Plants and Brain Health

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