Medicinal Plants as Potential Hemostatic Agents

Abstract

Purpose: Medicinal plants with a variety of phytochemical ingredients remain a potential source for new drug discovery. The use of medicinal herbs in a wide range of diseases and symptoms, such as bleeding, is prevalent in traditional and ethno medicine worldwide. Thus, this work provides a comprehensive review of medicinal plants or their isolated compounds, with respect to their ethno-medicinal use, which have demonstrated the stimulating effect on the hemostasis process. Methods: The relevant studies were withdrawn from electronic databases including Pubmed, EMBASE and Web of Science with a structured search methodology. Results: The total of 17 medicinal plants with hemostatic activity were extracted. The most frequently studied plant families were Compositae, Lamiaceae, Fabaceae, and Asteraceae. Bioactive compounds exerting hemostatic activity included tannins, iridoid glycosides, glycoconjugate, lignan, saponins and phenolic compounds. The most attributed mechanisms include coagulation stimulation via increasing the factor XII activity and plasma fibrinogen levels, the fibrinolysis inhibition, vascular or smooth muscle constriction and platelet aggregation. The most important adverse effects of high dose extract or isolated compounds administration were hepatotoxicity and nephrotoxicity. Conclusion: This review provides a list of medicinal plants with hemostatic activity that could be used as valuable sources of new plant-based hemostatic agents. Furthermore, this could be practical in detecting possible interactions of plants with anticoagulant, antiplatelet, fibrinolytic and antifibrinolytic medications. __________________________________________________________________________________________

Impact of antibiotics as anthropogenic stressor for influencing bacterial evolutionary process – A review

“…In the study of Ebrahimi et al (2020) also were investigated the total of 17 medicinal plants with hemostatic activity. The most frequently studied plant families were Compositae, Lamiaceae, Fabaceae, and Asteraceae.…”

New Insights into the Biological Activity of Lichens: Bioavailable Secondary Metabolites of Umbilicaria decussata as Potential Anticoagulants

“…A substantial number of studies have highlighted the role of many polyphenolic compounds in the hemostasis process [18–23] . Besides this, there are a small number of studies related to the impact of lichens and their different extracts on blood coagulation.…”

“…There is some evidence for the inhibitory effect of various plant polyphenols or polyphenol‐rich extracts on thrombin and factor Xa. Moreover, some polyphenols can directly inhibit the amidolytic or proteolytic activity of thrombin [21,22] which is a serine protease that catalyzes the conversion of fibrinogen to fibrin in the first steps of the blood coagulation pathway. Therefore, we assume that major bioavailable components of U. decussata ’s AE might directly or indirectly inhibit the active coagulation factors or thrombin in plasma.…”

Potential applications of Chinese herbal medicines with hemostatic properties

“…Ebrahimi et al comprehensively reviewed the ethno-pharmaceutical applications of medicinal plants or their isolates that stimulate the hemostatic process (62). Although that report included non-Chinese herbal medicine, the authors found via a literature search that several plants could be considered as sources of new herbal hemostatic medicines.…”