Medicinal plants as potential therapeutic agents for trypanosomosis: a systematic review

Plaatjie, Moitshepi; Onyiche, ThankGod E.; Legoabe, Lesetja J.; Ramatla, Tsepo; Nyembe, Nthatisi; Suganuma, Keisuke; Thekisoe, Oriel

doi:10.1007/s13596-022-00662-2

Cited by 2 publications

(2 citation statements)

References 86 publications

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“…Therefore, the investigation of herbal remedies is of high practical relevance. There have been several reports on the antitrypanosomal activity of traditionally used African medicinal plants [9][10][11][12][13][14][15][16][17][18][19]; this is the first such study from Angola.…”

Section: Introductionmentioning

confidence: 92%

Antitrypanosomal Constituents from Brasenia schreberi and Nymphaea lotus Used in a Single Herbal Preparation against Sleeping Sickness in Angola

Vahekeni,

Brillatz,

Rahmaty

et al. 2024

Preprint

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Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we have selected nine medicinal plants and assessed their antitrypanosomal ac-tivity. 122 extracts were prepared using different plant parts and solvents. 15 extracts from seven different plants exhibited in vitro activity against Trypanosoma brucei rhodesiense bloodstream forms >70% at 20 µg/ml. The dichloromethane extract of Nymphaea lotus (leaves and leaflets) and the ethanolic extract of Brasenia schreberi (leaves) had IC50 values ≤10 µg/ml. These two aquatic plants are of particular interest. They are being co-applied in the form of a decoction of leaves because they are considered by local healers as male and female of the same species, the ethnotaxon “longa dia simbi”. Bioassay-guided fractionation led to the identification of eight active molecules: gallic acid (IC50 0.5 µg/ml), methyl gallate (IC50 1.1 µg/ml), 2,3,4,6-tetragalloyl-glucopyranoside, ethyl gallate (IC50 0.5µg/ml), 1,2,3,4,6-pentagalloyl-β-glucopyranoside (IC50 20µg/ml), gossypet-in-7-O-β-glucopyranoside (IC50 5.5µg/ml), and hypolaetin-7-O-glucoside (IC50 5.7µg/ml) in B. schreberi, and 5-[(8Z,11Z,14Z)-heptadeca-8,11,14-trienyl] resorcinol (IC50 5.3µg/ml) not described to date in N. lotus. Five of these active constituents were detected in the traditional preparation. This work provides the first evidence for the ethnomedicinal use of these plants in the management of sleeping sickness in Angola.

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Section: Introductionmentioning

confidence: 92%

Antitrypanosomal Constituents from Brasenia schreberi and Nymphaea lotus Used in a Single Herbal Preparation against Sleeping Sickness in Angola

Vahekeni,

Brillatz,

Rahmaty

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhodesiense

Vahekeni,

Brillatz,

Rahmaty

et al. 2024

Molecules

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Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants and assessed their antitrypanosomal activity. A total of 122 extracts were prepared using different plant parts and solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (>70% at 20 µg/mL) against Trypanosoma brucei rhodesiense bloodstream forms. The dichloromethane extract of Nymphaea lotus (leaves and leaflets) and the ethanolic extract of Brasenia schreberi (leaves) had IC50 values ≤ 10 µg/mL. These two aquatic plants are of particular interest. They are being co-applied in the form of a decoction of leaves because they are considered by local healers as male and female of the same species, the ethnotaxon “longa dia simbi”. Bioassay-guided fractionation led to the identification of eight active molecules: gallic acid (IC50 0.5 µg/mL), methyl gallate (IC50 1.1 µg/mL), 2,3,4,6-tetragalloyl-glucopyranoside, ethyl gallate (IC50 0.5 µg/mL), 1,2,3,4,6-pentagalloyl-β-glucopyranoside (IC50 20 µg/mL), gossypetin-7-O-β-glucopyranoside (IC50 5.5 µg/mL), and hypolaetin-7-O-glucoside (IC50 5.7 µg/mL) in B. schreberi, and 5-[(8Z,11Z,14Z)-heptadeca-8,11,14-trienyl] resorcinol (IC50 5.3 µg/mL) not described to date in N. lotus. Five of these active constituents were detected in the traditional preparation. This work provides the first evidence for the ethnomedicinal use of these plants in the management of sleeping sickness in Angola.

show abstract

Medicinal plants as potential therapeutic agents for trypanosomosis: a systematic review

Cited by 2 publications

References 86 publications

Antitrypanosomal Constituents from <em>Brasenia schreberi</em> and <em>Nymphaea lotus</em> Used in a Single Herbal Preparation against Sleeping Sickness in Angola

Antitrypanosomal Constituents from <em>Brasenia schreberi</em> and <em>Nymphaea lotus</em> Used in a Single Herbal Preparation against Sleeping Sickness in Angola

Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhodesiense

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