Medicinal plants of genus Curculigo: Traditional uses and a phytochemical and ethnopharmacological review

Nie, Yongzhan; Dong, Xin; He, Yunfei; Yuan, Tingting; Han, Ting; Rahman, Khalid; Qin, Lu‐Ping; Zhang, Qiaoyan

doi:10.1016/j.jep.2013.03.066

Cited by 97 publications

(62 citation statements)

References 67 publications

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“…As shown by Olsen and Larsen [20], the livelihoods of people of western Nepal heavily depend on the collection and trade of medicinal plants. Within the three districts that were studied, a total of 42 species or products were found to be collected and traded for both subsistence and commercial purposes (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…The Baidhya healing system, prevalent in the mid-hills of western Nepal [14], is influenced by the Ayurveda . Baidhya medicinal practitioners (particularly of western Nepal mid hills [71] and adjoining areas of India [84]) were common among privileged groups and pursued remedies to cure diseases and aliments by using nearby medicinal plants. Their knowledge base for therapies stems from custom, livelihood strategies, and available resources.…”

Section: Resultsmentioning

confidence: 99%

“…Numerous drugs have been introduced to international markets [16] through validation of traditional medicines [17], indigenous therapies [18,19], and ethnopharmacological practices [20]. Sustainable utilization and management of medicinal plants based on traditional knowledge is therefore necessary.…”

Section: Introductionmentioning

confidence: 99%

“…This effort should acknowledge empirical data and ethnoecological knowledge [22,23]. Far-west Nepal is the least studied area in Nepal [20]. The present study was thus an attempt to catalogue the important medicinal plants of Far-west Nepal along with their traditional uses and management interventions.…”

Section: Introductionmentioning

confidence: 99%

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Medicinal plants, traditional medicine, markets and management in far-west Nepal

Kunwar

Mahat

Acharya³

et al. 2013

J Ethnobiology Ethnomedicine

312

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BackgroundModern therapeutic medicine is historically based on indigenous therapies and ethnopharmacological uses, which have become recognized tools in the search for new sources of pharmaceuticals. Globalization of herbal medicine along with uncontrolled exploitative practices and lack of concerted conservation efforts, have pushed many of Nepal's medicinal plants to the verge of extinction. Sustainable utilization and management of medicinal plants, based on traditional knowledge, is therefore necessary.MethodsAfter establishing verbal informed consent with participating communities, five field surveys, roughly 20 days in duration, were carried out. In all, 176 schedules were surveyed, and 52 participants were consulted through focus group discussions and informal meetings. Altogether, 24 key informants were surveyed to verify and validate the data. A total of 252 individuals, representing non-timber forest product (NTFP) collectors, cultivators, traders, traditional healers (Baidhya), community members, etc. participated in study. Medicinal plants were free-listed and their vernacular names and folk uses were collected, recorded, and applied to assess agreement among respondents about traditional medicines, markets and management.ResultsWithin the study area, medicinal herbs were the main ingredients of traditional therapies, and they were considered a main lifeline and frequently were the first choice. About 55% plants were ethnomedicinal, and about 37% of ethnomedicinal plants possessed the highest informant consensus value (0.86–1.00). Use of Cordyceps sinensis as an aphrodisiac, Berberis asiatica for eye problems, Bergenia ciliata for disintegration of calculi, Sapindus mukorossi for dandruff, and Zanthoxylum armatum for toothache were the most frequently mentioned. These species possess potential for pharmacology.ConclusionMedicinal plants are inseparable from local livelihoods because they have long been collected, consumed, and managed through local customs and knowledge. Management of traditional therapies is urged, because the therapies are empirically and knowledge based, often culturally inherited and important to pharmacology and local livelihoods. However, traditional therapies are currently being eroded due to changing lifestyles, perceptions, social transformations, and acculturation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Medicinal plants, traditional medicine, markets and management in far-west Nepal

Kunwar

Mahat

Acharya³

et al. 2013

J Ethnobiology Ethnomedicine

312

View full text Add to dashboard Cite

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“…The rhizome of Curculigo orchioides, also known as 'Xian Mao' , is commonly used as a tonic in traditional Chinese medicine to treat a decline in physical strength (Editorial Committee of Zhonghua Bencao National Traditional Chinese Herb Administration, 1996; Nie et al, 2013). Modern pharmacological investigations on cells and animals have proved that Curculigo orchioides has potential anti-osteoporosis, immunostimulatory and antihistaminic effects (Cao et al, 2008;Bafna and Mishra, 2006;Lakshmi et al, 2003;Venkatesh et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

An LC‐MS/MS method for determination of curculigoside with anti‐osteoporotic activity in rat plasma and application to a pharmacokinetic study

Zhao

Yuan

Zhu

2013

Biomedical Chromatography

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A rapid, simple, selective and sensitive LC-MS/MS method was developed for the determination of curculigoside in rat plasma. The analytical procedure involves extraction of curculigoside and syringin (internal standard, IS) from rat plasma with a one-step extraction method by protein precipitation. The chromatographic resolution was performed on an Agilent XDB-C18 column (4.6 × 50 mm, 5 µm) using an isocratic mobile phase of methanol with 0.1% formic acid and H2 O with 0.1% formic acid (45:55, v/v) at a flow rate of 0.35 mL/min with a total run time of 2.0 min. The assay was achieved under the multiple-reaction monitoring mode using positive electrospray ionization. Method validation was performed according to US Food and Drug Administration guidelines and the results met the acceptance criteria. The calibration curve was linear over 4.00-4000 ng/mL (R = 0.9984) for curculigoside with a lower limit of quantification of 4.00 ng/mL in rat plasma. The intra- and inter-day precisions and accuracies were 3.5-4.6 and 0.7-9.1%, in rat plasma, respectively. The validated LC-MS/MS method was successfully applied to a pharmacokinetic study of curculigoside in rats after a single intravenous and oral administration of 3.2 and 32 mg/kg. The absolute bioavailability of curculigoside after oral administration was 1.27%.

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Curculigo recurvata W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model

Ahmad

Nasrin

Reza

et al. 2020

Anim Models and Exp Med

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BackgroundCurculigo recurvata (C. recurvata) is an enthnomedicinally important herb reported to have significant medicinal values. The present study aimed to explore the in vivo and in silico anti‐nociceptive and anti‐diarrheal effects of a C. recurvate rhizome methanol extract (Me‐RCR).MethodsThe analgesic effects of Me‐RCR were assessed using acetic acid‐induced writhing and the formalin‐induced flicking test. The drugs were administered intraperitoneally (IP) at doses of 200 and 400 mg/kg body weight (bw). Anti‐diarrheal activity was evaluated by assessing intestinal motility, hypersecretion, and fecal score in mice at oral doses of 200 and 400 mg/kg·bw. Computer facilitated analyses for anti‐nociceptive and anti‐diarrheal activities of three isolated compounds from C. recurvata were undertaken to identify the best‐fit phytoconstituents.ResultsThe Me‐RCR showed significant (P < .05) peripheral anti‐nociception at the highest dose. The extract inhibited both early and late phases of nociception in the formalin‐induced writhing test. In the castor oil‐induced diarrhoea model, the extract significantly (P < .05) prolonged the onset time of diarrhoea, inhibited percentage of diarrhoea, and decreased both the volume and weight of intestinal contents. Rates of intestinal fluid accumulation inhibition were (33.61 ± 1.00)% and (46.44 ± 0.89)% at Me‐RCR doses of 200 and 400 mg/kg·bw, respectively. Moreover, a significant (P < .05) reduction in gastrointestinal motility was observed. An absorption, distribution, metabolism, excretion and/or toxicity (ADME/T) test showed that the selected compounds yielded promising results, satisfying Lipinski's rule of five for predicting drug‐like potential. Notably, of the three phytoconstituents curculigine and isocurculigine possessed the highest affinity for the COX‐1 and COX‐2. Isocurculigine was also identified as the most effective anti‐diarrheal compound in the computer‐facilitated model.ConclusionAn extract of the plant C. recurvata showed potential analgesic and anti‐diarrheal activity due to the presence of one or more active secondary metabolite(s).

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Medicinal plants of genus Curculigo: Traditional uses and a phytochemical and ethnopharmacological review

Cited by 97 publications

References 67 publications

Medicinal plants, traditional medicine, markets and management in far-west Nepal

Medicinal plants, traditional medicine, markets and management in far-west Nepal

An LC‐MS/MS method for determination of curculigoside with anti‐osteoporotic activity in rat plasma and application to a pharmacokinetic study

Curculigo recurvata W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model

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