Medicinal plants of the Caatinga, northeastern Brazil: Ethnopharmacopeia (1980–1990) of the late professor Francisco José de Abreu Matos

Magalhães, Karla do Nascimento; Sagástegui-Guarniz, William Antonio; Sá, Kellen Miranda; Freire, Amélia Branches; Monteiro, Mirian Parente; Nojosa, Ronald Targino; Bieski, Isanete Geraldini Costa; Custódio, Jéssica Bezerra; Balogun, Sikiru Olaitan; Bandeira, Mary Anne Medeiros

doi:10.1016/j.jep.2019.03.032

Cited by 78 publications

(41 citation statements)

References 62 publications

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“…In ethnobotanical studies, M. suaveolens has been reported to treat certain disorders such as gastrointestinal tract disorders [34,35]. The use of M. suaveolens in folk medicine is justified, since the species has chemical compounds capable of decreasing the proliferation of Candida strains.…”

Section: Discussionmentioning

confidence: 99%

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

et al. 2020

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The emergence of fungal resistance to commercial drugs has been a major problem for the WHO. In this context, research with natural products is promising in the discovery of new active substances. Thus, this work evaluated the antifungal effect of a medicinal plant (i.e., Mesosphaerum suaveolens) against strains of the genus Candida, tested the combined effect with the drug fluconazole, and, finally, determined the phenolic constituents present in the species. Initially, aqueous extracts of leaves (AELMs) and aerial parts (AEAPMs) of the species were prepared. For microbiological assays, the minimum fungicidal concentration was determined by broth microdilution, and the combined effect of fluconazole extracts were verified by sub-inhibitory microdilution concentrations (CFM/8) followed by spectrophotometric readings which were used to determine the IC50. HPLC detected the presence of flavonoids and phenolic acids, detecting eight compounds present in the samples of which caffeic acid and quercetin were major components. The AELMs modulated fluconazole activity since it decreased fluconazole’s IC50 from 7.8 µg/mL to an IC50 of 4.7 µg/mL (CA LM 77) and from 28.8 µg/mL to 18.26 µg/mL (CA INCQS 40006) for the C. albicans strains. The AEAPMs were able to potentiate the effect of fluconazole more effectively than the AELMs. Such an effect was significant for the 16 µg/mL concentration for CA LM 77 and 32 µg/mL for CA INCQS 40006. The AEAPMs as well as the AELMs presented clinically relevant activities for C. tropicalis strains. For the C. tropicalis LM 23 strain, the AEPMs obtained an IC50 of 25 µg/mL and the AELMs an IC50 of 359.9 µg/mL.

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Section: Discussionmentioning

confidence: 99%

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

et al. 2020

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“…The leaves of Phyllanthus niruri L., which belongs to the Phyllanthaceae family and is popularly known as "quebra-pedra" in Brazil and "gale of the wind" or "stonebreaker" in English, are used as a diuretic to eliminate kidney stones and for renal colic [85][86][87][88]. Its composition includes flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins, and saponins [87][88]. The alkaloids are related to antispasmodic activity, leading to smooth muscle relaxation, mostly evidenced in the urinary tract, which facilitates the elimination of urinary calculi, hence the main application of this species to treat kidney stones [86].…”

Section: Future Prospectsmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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“…Frequentemente está entre as espécies mais citadas, inclusive em comunidades localizadas em área de baixa ocorrência populacional da espécie (Saraiva et al, 2015) (Paulino et al, 2011); 1,21 (Oliveira, Barros, & Moita Neto, 2010), 1,28 (Magalhães et al, 2019), 1,4 (Saraiva et al, 2015), 1,87 (Macedo et al, 2018), e 1,94 (Cartaxo, Souza, & Albuquerque, 2010). Isso demonstra que a aroeira figura entre as espécies mais importantes nas comunidades estudadas.…”

Section: Etnobotânicaunclassified

Uso, conhecimento e conservação de Myracrodruon urundeuva: uma revisão sistemática

Domingos

Silva

2020

RSD

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Myracrodruon urundeuva, conhecida popularmente como aroeira, é amplamente distribuída no território brasileiro e considerada espécie polivalente por sua diversidade de usos, que incluem aplicações como combustível, madeira, forragem, apicultura, recuperação de áreas e o uso medicinal, muito praticado por populações rurais. Essa diversidade de aplicações pode ameaçar a conservação da espécie devido à exploração excessiva e o uso de técnicas inadequadas que podem resultar em declínio das populações naturais. Com este trabalho, o objetivo foi verificar o conhecimento atual sobre M. urundeuva e seu estado de conservação. Para tanto, foi realizada uma revisão sistemática seguindo o modelo PRISMA, com busca de artigos publicados entre 2010 e 2020. Foram identificados inicialmente 333 artigos, dos quais 165 foram incluídos na revisão. Os artigos se distribuem nas categorias atividade biológica, biologia vegetal e ecologia, composição química, etnobotânica e produção. A maior parte dos estudos diz respeito à avaliação das atividades biológicas da espécie com evidências de efeitos anti-inflamatório, antimicrobiano, antioxidante, antifúngico, antiviral, inseticida e neuroprotetor entre outros, corroborando aplicações terapêuticas da espécie descritas em estudos etnobotânicos. A aroeira não é considerada oficialmente ameaçada de extinção. Embora muitos autores asseverem que a exploração excessiva da espécie seja uma ameaça a sua conservação, não foram encontrados dados que suportem tal suposição. São necessários estudos que avaliem o estado populacional da espécie, a condição ambiental de sua área de distribuição e seu volume de exploração, para que se possa avaliar adequadamente o estado de conservação da espécie e proposição de medidas para seu uso sustentável.

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Medicinal plants of the Caatinga, northeastern Brazil: Ethnopharmacopeia (1980–1990) of the late professor Francisco José de Abreu Matos

Cited by 78 publications

References 62 publications

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

Uso, conhecimento e conservação de Myracrodruon urundeuva: uma revisão sistemática

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