Medicinal plants used for cardiovascular diseases in Navarra and their validation from Official sources

Calvo, María Isabel; Cavero, Rita Yolanda

doi:10.1016/j.jep.2014.09.047

Cited by 34 publications

(24 citation statements)

References 33 publications

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“…C. erythraea is used in traditional medicine to treat cardiovascular diseases, namely hypertension [3][4][5][6]. To the best of our knowledge, this is the first study that aimed to investigate the effects of C. erythraea extracts on the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

et al. 2019

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Centaurium erythraea is a plant used in traditional medicine for several cardiovascular disorders, namely hypertension, but there is no scientific evidence able to provide a molecular basis for its claimed antihypertensive effects. After a preliminary screen of extracts obtained from sequential extraction of C. erythraea aerial parts, effects of the methanolic fraction (MFCE) on changes in perfusion pressure of isolated rat mesenteric vascular bed (MVB) and in rat cardiac fibroblasts proliferation were investigated, gathering information on the mechanisms involved in endothelium-dependent effects and their dependence on a pro-proliferative stimulus. The HPLC-DAD determination of the phenolics content of MFCE revealed the presence of 22 phenolic compounds. MFCE reduced (63.3 ± 3.9%; n = 4) perfusion pressure in MVB and almost completely abrogated the Ang II-induced increase in cardiac fibroblasts proliferation. Reduction of the perfusion pressure caused by MFCE was endothelium-dependent and occurred in parallel with an increase in NO release. These effects were inhibited by muscarinic receptor antagonists, by L-NAME (a NO synthase inhibitor), and by ODQ (a soluble guanylate cyclase inhibitor). Experiments revealed that effects required the involvement of K+ channels, being inhibited by tetraethylamonium (TEA; a Ca2+ activated K+ channels inhibitor) and by glibenclamide (an ATP-sensitive K+ channels inhibitor). In conclusion, extracts from C. erythraea, particularly the compounds present in the MFCE, induce endothelium-dependent vasodilation and prevent fibroblast proliferation induced by angiotensin II, which can account for the claimed antihypertensive effects of C. erythraea in traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

et al. 2019

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“…It is a perennial deciduous plant growing as a shrub on wild uncultivated areas; although native of Italy, it can be also found in other European countries and in temperate regions of Asia. Despite being widespread in Italy, its ethnobotanical use is not well known as in other countries, where branch infusions are used in the treatment of hypertension and its macerated fruits for gastrointestinal disturbances [ 5 ]. The active compounds of Prunus spinosa mainly contain phenolic acids, flavonoids and anthocyanins [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Apoptotic Activities of Prunus spinosa Trigno Ecotype Extract on Human Cancer Cells

Meschini¹,

Pellegrini²,

Condello³

et al. 2017

Molecules

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The aim of this work was to demonstrate that a natural compound, not-toxic to normal cells, has cytotoxic and sensitizing effects on carcinoma cells, with the final goal of combining it with chemotherapeutic drugs to reduce the overall dose. Prunus spinosa Trigno ecotype (PsT) drupe extract with a nutraceutical activator complex (NAC) made of amino acids, vitamins and mineral salt blends, has shown in vitro anticancer activity. The cytotoxic effect of (PsT + NAC)® has been evaluated on human cancer cells, with an initial screening with colorectal, uterine cervical, and bronchoalveolar cells, and a subsequent focus on colon carcinoma cells HCT116 and SW480. The viability reduction of HCT116 and SW480 after treatment with (PsT 10 mg/mL + NAC)® was about 40% (p < 0.05), compared to control cells. The cell’s survival reduction was ineffective when the drug vehicle (NAC) was replaced with a phosphate buffer saline (PBS) or physiological solution (PS). The flow cytometry evaluation of cancer cells’ mitochondrial membrane potential showed an increase of 20% depolarized mitochondria. Cell cycle analysis showed a sub G1 (Gap 1 phase) peak appearance (HCT116: 35.1%; SW480: 11.6%), indicating apoptotic cell death induction that was confirmed by Annexin V assay (HCT116: 86%; SW480: 96%). Normal cells were not altered by (PsT + NAC)® treatments.

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“…Despite being widespread in Spain, its ethnobotanic use is best known in Navarra, where infusions of its branches are used in the treatment of hypertension (Calvo & Cavero, 2014), and its macerated fruits for gastrointestinal disturbances and in the preparation of a type of schnapps called 'pacharan' (Calvo, Akerreta, & Cavero, 2013). It contains substantial quantities of phenolic antioxidants (Ruíz-Rodríguez et al, 2014;Velickovic et al, 2014), including specifically, flavonol heterosides (quercetin and kaempferol), phenolic acids (neochlorogenic and caffeic derivatives), coumarin derivatives as aesculetin, umbelliferone and scopoletin, anthocyanins and type A proanthocyanidins which are a class of secondary metabolites consisting of units of flavan-3-ol bound together by one or two interflavan bonds.…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds of blackthorn (Prunus spinosa L.) and influence of in vitro digestion on their antioxidant capacity

Pinacho

Cavero

Astiasarán

et al. 2015

Journal of Functional Foods

110

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Available online A B S T R A C TTotal phenolic, flavonoid and anthocyanin contents of dichloromethane, ethyl acetate, ethanol, and aqueous extracts of branches, leaves and fruits from Prunus spinosa were quantified by spectrophotometrical methods and the results showed solvent and botanical organ dependence. In order to detect antioxidant activity, a method based on the reduction of DPPH was carried out. Activity of ethanol, ethyl acetate and aqueous extracts of branches demonstrated a higher scavenging capacity compared to other analysed extracts. Phytochemical analysis allowed detecting flavonoids, coumarins, phenolic acids and flavan-3-ols. Ethanolic extract of branches was subjected to an in vitro digestion. Buccal and gastric digestion had no substantial effect on any of the phenolic compounds. However, these compounds were significantly altered during intestinal digestion. The results showed that a significant proportion of these compounds would be transformed into other unknown and/or undetected structural forms. Furthermore, three phenolic acids, two coumarins, fourteen flavan-3-ols, and six flavonols were identified using HPLC-DAD-ESI-MS.

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Medicinal plants used for cardiovascular diseases in Navarra and their validation from Official sources

Cited by 34 publications

References 33 publications

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

Centaurium Erythraea Extracts Exert Vascular Effects through Endothelium- and Fibroblast-dependent Pathways

Cytotoxic and Apoptotic Activities of Prunus spinosa Trigno Ecotype Extract on Human Cancer Cells

Phenolic compounds of blackthorn (Prunus spinosa L.) and influence of in vitro digestion on their antioxidant capacity

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