Medicinal plants used for the treatment of sexually transmitted infections in the Maseru District, Lesotho: Antimicrobial validation, phytochemical and cytotoxicity studies

Seleteng‐Kose, Lerato; Moteetee, A.; Vuuren, Sandy van

doi:10.1016/j.sajb.2019.01.035

Cited by 16 publications

(6 citation statements)

References 80 publications

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“…Indeed, A. afra has been used to keep the urine free from sugar in the case of diabetes mellitus (Watt & Breyer-Brandwijk 1962). A publication by Seleteng-Kose et al (2019) investigated 20 plant species used for the treatment of sexually transmitted infections (STIs) in Maseru, Lesotho for antimicrobial activity against three prevalent causative pathogens of STIs (Gardnerella vaginalis, Oligella ureolytica and Neisseria gonorrhoea), as well as Candida albicans. Bulbine narcissifolia and Helichrysum caespititium displayed noteworthy antimicrobial activity against more than one of the test pathogens, whereas Senecio asperulus was found to display noteworthy activity against N. gonorrhoea.…”

Section: Biological Activity Studiesmentioning

confidence: 99%

“…On the other hand, several studies have been undertaken to investigate the efficacy of some of the medicinal plants used in Lesotho as a step towards the provision of scientific validation. These studies include investigations of the antimicrobial activity, e.g., Mekbib (2016), andSeleteng-Kose et al (2019) anti-inflammatory, e.g., Shale et al(1999), Shale et al (2004), Kena and Lepheana (2016), as well as antioxidant activity, e.g., Magama et al (2013), Asita et al(2015), as well as phytochemistry, e.g., Qhotsokoane-Lusunzi and Karuso (2001), Mugomeri et al (2014) and toxicity, e.g. Seleteng-Kose et al (2019).…”

Section: Introductionmentioning

confidence: 99%

“…These studies include investigations of the antimicrobial activity, e.g., Mekbib (2016), andSeleteng-Kose et al (2019) anti-inflammatory, e.g., Shale et al(1999), Shale et al (2004), Kena and Lepheana (2016), as well as antioxidant activity, e.g., Magama et al (2013), Asita et al(2015), as well as phytochemistry, e.g., Qhotsokoane-Lusunzi and Karuso (2001), Mugomeri et al (2014) and toxicity, e.g. Seleteng-Kose et al (2019). Despite many research activities on Lesotho plants used for medicinal purposes, a comprehensive synthesis of such studies has hitherto not been published.…”

Section: Introductionmentioning

confidence: 99%

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Medicinal plants of Lesotho: A review of ethnomedicinal, pharmacological and conservation studies

Motjotji

Moteetee

Seleteng‐Kose

2023

Ethnobot. Res. App.

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Background: Of the approximately 2,076 plant species occurring in Lesotho, about 355 are used for medicinal purposes. Many communities in the country, mainly in rural areas with limited access to health facilities, rely on traditional medicine as primary healthcare. Several publications provide helpful information on plants used for medicinal purposes in Lesotho. These include documentation of the plants, investigation of their therapeutic potential to provide scientific validation for their use, and conservation status. However, a synthesis of all the studies conducted so far has hitherto not been undertaken. The current study aimed to provide a systematic review of ethnomedicinal, pharmacological, and conservation studies undertaken on medicinal plants of Lesotho. The synthesis brings together published and unpublished literature sources, thus providing a comprehensive database for studies conducted on Lesotho medicinal plants. Furthermore, it identifies existing knowledge gaps on research that has been carried out on the species and thus provides opportunities for further research, especially in the search for new natural products. Methods: Information was gathered from published and unpublished literature sources, with the earliest publication dating back to 1917. Information was gathered through keyword search using accessible literature sources from Google Scholar, Science Direct, Scopus and PubMed. Books, dissertations, theses, technical reports were also searched. Keywords used for the search were Lesotho, in conjunction with medicinal plant and traditional medicine. To be eligible for inclusion in the current review, a literature source was expected to have assessed ethnomedicinal use, biological/pharmacological activity (e.g., antimicrobial activity), phytochemistry, toxicology) or conservation status of any Lesotho plant species used in traditional medicine.Results: A total of 116 records were identified, of which 76 were included in the review. Thirty-one ethnomedicinal, 14 pharmacological (nine antioxidant, three anti-inflammatory, five antimicrobial activities), six phytochemical, and 15 conservation studies on medicinal plants of Lesotho were scrutinized. It is important to note that some studies evaluated more than one pharmacological activity. Ethnomedicinal studies show that numerous plants are used for medicinal purposes in Lesotho, however studies to scientifically validate their traditional use has remained far behind.Conclusion: Many of Lesotho's important medicinal plants have been assessed for pharmacological activity, providing scientific proof for their use. However, there are numerous gaps in the number and type of pharmacological and phytochemical studies that have been conducted. These gaps offer endless opportunities for researchers working in these fields. In addition, the conservation status for most of these plants is unknown., therefore, a detailed red data listing of Lesotho plants, particularly those used in traditional medicine, is recommended.

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Section: Biological Activity Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Medicinal plants of Lesotho: A review of ethnomedicinal, pharmacological and conservation studies

Motjotji

Moteetee

Seleteng‐Kose

2023

Ethnobot. Res. App.

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“… Seleteng-Kose et al (2019) evaluated 20 plants against C. albicans using their aqueous and organic (dichloromethane: methanol) extracts (leaf and stem roots). Only four plant species, Bulbine narcissifolia Salm-Dyck roots ( Figure 5 ) (aqueous and organic extracts), Helichrysum caespititium (DC.)…”

Section: Potential Bioactive Compounds Against Sexually Transmitted Diseases Pathogens: Mechanisms and Molecular Targetsmentioning

confidence: 99%

Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action

et al. 2021

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Sexually transmitted diseases (STDs) are produced by pathogens like bacteria, fungi, parasites, and viruses, and may generate severe health problems such as cancer, ulcers, and even problems in the newborn. This narrative review aims to present updated information about the use of natural bioactive compounds for the prevention and treatment of sexually transmitted infections. A search of the literature was performed using databases and search engines such as PubMed, Scopus, Google Scholar and Science Direct. From the pharmacotherapeutic management point of view, any strategies for prevention should contain medical approaches. The bioactive compounds obtained from natural products have shown biological effects against different microorganisms for the treatment of these diseases. The main results showed antimicrobial, antiprotozoal, antifungal and antiviral effects such as HIV. Also, the molecular mechanisms, signalling pathways and action targets of natural compounds were highlighted, thus justifying bacterial and antifungal inhibition, apoptosis or reduction of viral replication. From the data of our study, we can conclude that natural compounds may be a significant source for adjuvant drugs / complementary therapies in the treatment of STDs. With all these benefits, the future must conduct extensive clinical trials and the development of pharmaceutical nanotechnologies for a greater therapeutic effect.

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“…However, studies have shown that many plants used as food or traditional medicine are toxic [26][27][28]. Toxicity studies of southern African medicinal plants traditionally used against infectious diseases have recently gained popularity [27][28][29][30][31]. Most toxicity assays of plant extracts have hitherto focused on prospecting for compounds that are cytotoxic against cancerous cells rather than normal human cells [30].…”

Section: Introductionmentioning

confidence: 99%

South Africa’s Best BARK Medicines Prescribed at the Johannesburg Muthi Markets for Skin, Gut, and Lung Infections: MIC’s and Brine Shrimp Lethality

et al. 2021

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Indigenous trade of medicinal plants in South Africa is a multi-million-rand industry and is still highly relevant in terms of primary health care. The purpose of this study was to identify today’s most traded medicinal barks, traditionally and contemporaneously used for dermatological, gastrointestinal, and respiratory tract infections; then, to investigate the antimicrobial activity and toxicity of the respective extracts and interpret outcomes in light of pharmacokinetics. Thirty-one popularly traded medicinal barks were purchased from the Faraday and Kwa Mai-Mai markets in Johannesburg, South Africa. Information on the medicinal uses of bark-based medicines in modern commerce was recorded from randomly selected traders. The minimum inhibitory concentration (MIC) method was used for antimicrobial screening, and brine shrimp lethality was used to determine toxicity. New medicinal uses were recorded for 14 bark species. Plants demonstrating some broad-spectrum activities against tested bacteria include Elaeodendron transvaalense, Erythrina lysistemon, Garcinia livingstonei, Pterocelastrus rostratus, Rapanea melanophloeos, Schotia brachypetala, Sclerocarya birrea, and Ziziphus mucronata. The lowest MIC value of 0.004 mg/mL was observed against Staphylococcus epidermidis for a dichloromethane bark extract of E. lysistemon. The tested medicinal barks were shown to be non-toxic against the Artemia nauplii (brine shrimp) bioassay, except for a methanol extract from Trichilia emetica (69.52% mortality). Bacterial inhibition of bark extracts with minimal associated toxicity is consistent with the safety and valuable use of medicinal barks for local muthi market customers. Antimicrobial outcomes against skin and gastrointestinal pathogens are feasible because mere contact-inhibition is required in vivo; however, MIC values against respiratory pathogens require further explaining from a pharmacokinetics or pharmacodynamics perspective, particularly for ingested rather than smoked therapies.

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Medicinal plants used for the treatment of sexually transmitted infections in the Maseru District, Lesotho: Antimicrobial validation, phytochemical and cytotoxicity studies

Cited by 16 publications

References 80 publications

Medicinal plants of Lesotho: A review of ethnomedicinal, pharmacological and conservation studies

Medicinal plants of Lesotho: A review of ethnomedicinal, pharmacological and conservation studies

Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action

South Africa’s Best BARK Medicines Prescribed at the Johannesburg Muthi Markets for Skin, Gut, and Lung Infections: MIC’s and Brine Shrimp Lethality

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