Medicinal plants: used in Anti-cancer treatment

Tyagi, Nidhi; Sharma, Ganesh N.; Shrivastava, Birendra; Saxena, Prasoon Kumar; Kumar, Nitin

doi:10.21276/ijrdpl.2278-0238.2017.6(5).2732-2739

Cited by 7 publications

(5 citation statements)

References 18 publications

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“…Around 70% of deaths in low-and middle-income countries are due to cancer. Since ancient times, natural products have been a good source for cancer treatment due to the presence of diverse active compounds [14] . For many centuries, indigenous traditional herbal medicines have been used to treat many diseases including cancer around the world.…”

Section: Resultsmentioning

confidence: 99%

Anticancer activity of leaves extract of Hypericum mysorense L.

Meenakshi¹,

Rajendiran²,

Sivaraj³

et al. 2020

J Pharmacogn Phytochem

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Medicinal plants have been used for the treatment of several diseases since ancient times, but their anticancer properties have not been well studied. Herbal medicine has been used as a major treatment for cancer in various countries in South East Asia and the Middle East and Europe a long time ago. People looked for drugs in nature to retaliate diseases based on experience and there was not sufficient information either concerning the reasons for the illnesses or concerning which plant and how it could be utilized as a cure. Although many advanced countries have considered traditional herbal medicine as an official treatment for cancer, only 5-15% of these herbs have been investigated to detect their bioactive anticancer compounds. Several plant-derived compounds have shown promising anticancer therapeutics and attempts have been made to characterize the effectiveness of active constituents to be isolated from natural sources as chemo-preventive agents for rapid relief. H. mysorense (Hypericaceae) found at high elevation in the Western Ghats of India especially in Nilgiris. H. mysorense are mentioned in traditional system of folklore for its skin-related disorders, wound healing, spasmolytic, antipsychotic antifungal, and antiviral and nerve-calming properties. The present study was conducted to determine the anticancer activity of methanol leaf extract of H. mysorense on HT29 and A549 cells by MTT assay method. The maximum dead cells of HT29 were 59.67±0.73% and dead cells of A549 were 63.27±1.80 at 100 µg/mL concentration by leaf extract of H. mysorense.

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Section: Resultsmentioning

confidence: 99%

Anticancer activity of leaves extract of Hypericum mysorense L.

Meenakshi¹,

Rajendiran²,

Sivaraj³

et al. 2020

J Pharmacogn Phytochem

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“…Chemotherapy treatment makes the patient under a lot of strain and also causes damage to their health. Therefore, there is a focus on using alternative treatments using some natural drugs against cancer disease 1 .…”

Section: Ijpsr (2021) Volume 12 Issue 1 (Research Article)mentioning

confidence: 99%

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2021

IJPSR

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“…While there has been substantial progress in the field, cancer continues to pose a global health threat. From a pathophysiological standpoint, cancer has a number of malignant features, including an increased number of cells proliferating and invaded neighbouring tissues, thereby leading to metastases [2]. Malignant melanoma has been one of the most widely studied cancers in recent years.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

SALAVAT¹

2022

FARMACIA

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Malignant melanoma is the most aggressive type of skin cancer, with an increasing annual incidence. In addition to cutaneous melanoma, another form of melanoma with an increased death rate is uveal melanoma. With both types of melanomas, there is a risk that the malignant cells will become resistant to conventional antitumour therapy. Thus, the present study aimed to evaluate the antitumour effect of a hydroalcoholic extract of Viscum album (VAex) on a pigmented cell line (B164A15) as well as unpigmented (A431). The cytotoxic effect was also followed in the case of a healthy human keratinocyte cell line. The results showed that at low concentrations (< 500 μg/mL), VAex has a selective cytotoxic effect, with healthy cells not being affected. In addition, in the case of tumour cells, VAex exerted a concentration-dependent cytotoxic effect, causing morphological and structural changes in the nucleus, with an apoptotic-like effect. The most affected cells were the unpigmented ones (A431), requiring additional studies to elucidate the mechanism of antitumour action, but also to determine the influence of melanin on the biological action of VAex. RezumatMelanomul malign este cel mai agresiv tip de cancer de piele, cu o incidență anuală în creștere. Pe lângă melanomul cutanat, o altă formă de melanom cu o rată crescută a mortalității este melanomul uveal. În cazul ambelor tipuri de melanoame, există riscul ca celulele maligne să devină rezistente la terapia antitumorală convențională. Astfel, studiul de față a avut ca scop evaluarea efectului antitumoral al unui extract hidroalcoolic de Viscum album (VAex) asupra unei linii celulare pigmentate (B164A15), precum și asupra unei linii celulare nepigmentate (A431). Efectul citotoxic a fost urmărit, de asemenea, în cazul unei linii celulare de keratinocite umane sănătoase. Rezultatele au arătat că, la concentrații mici (< 500 μg/mL), VAex are un efect citotoxic selectiv, celulele sănătoase nefiind afectate. În plus, în cazul celulelor tumorale, VAex a exercitat un efect citotoxic dependent de concentrație, provocând modificări morfologice și structurale în nucleu, cu un efect de tip apoptotic. Cele mai afectate au fost celulele nepigmentate (A431), fiind necesare studii suplimentare pentru elucidarea mecanismului de acțiune antitumorală, dar și pentru a determina influența melaninei asupra acțiunii biologice a VAex.

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Medicinal plants: used in Anti-cancer treatment

Cited by 7 publications

References 18 publications

Anticancer activity of leaves extract of Hypericum mysorense L.

Anticancer activity of leaves extract of Hypericum mysorense L.

Untitled

Polyphenols Content and in Vitro Antitumour Activity of Hydroalcoholic Extract of Viscum Album in Two Pigmented and Unpigmented Skin Cancer Cell Lines

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