Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Castañeda, Rodrigo; Cáceres, Armando; Velásquez, Diana; Rodríguez, César Andrés; Morales, David Michael; Castillo, Andrea

doi:10.1016/j.jep.2021.114746

Cited by 16 publications

(12 citation statements)

References 214 publications

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“…The ability of crude extracts or bioactive compounds to suppress different forms of seizures can be examined by animal models by artificially induced convulsions using maximal electroshock (MES) or drugs such as pentylenetetrazol (PTZ), picrotoxin (PIC), strychnine (STR), pilocarpine (PLC), isonicotinic hydrazide acid (INH), Kainic acid (KA), 4-aminophylline (AMP), bicuculline (BIC), etc. [ 144 ]. The similarity in the pattern of seizure triggered by different stimuli in animal models with humans, simplicity upon execution, quick response rate, and most importantly, predictive clinical outcomes in humans [ 145 ] make the in vivo seizure models trustworthy in epilepsy research.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

“…CAMs, especially herbal remedies are extensively used for the treatment of epilepsy across the globe due to their desirable treatment outcomes and tolerable side effects [ 144 ]. Moreover, herbal therapies may yield a new horizon for treating patients seeking inexpensive treatments for untreated epilepsy and experiencing refractory seizures.…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

“…It exhibited a dose-dependent inhibition of the convulsion induced by MES (90% protection at 20 mg/kg) [ 104 ] 10 Clerodendrum myricoides L HET PTZ Male BALB/c mice (22–30 g) 300–1200 Unlike the solvent fractions, the crude extract demonstrated a significant delay in the mean latency to onset of seizures and decrease the duration of convulsions in a dose-dependent manner [ 157 ] 11 Clutia abyssinica L HME PTZ & MES Male BALB/c mice (20–30 g) 400 & 800 Though the crude extract exhibited insignificant dose-dependent delay on the onset of a seizure, it improved the survival of mice [ 158 ] 12 Croton macrostachyus SB AQ PIC, STR, PTZ, INH & MES Adult male Mus musculus Swiss mice (19–25 g) 13–135 The crude extract prevented the mice from PIC, STR, PTZ, and MES-induced seizures. It also delayed the onset of INH-induced seizures [ 140 ] 13 Indigofera arrecta L ME PTZ Zebrafish with an AB or EK strain 30–300* The main constituent, idirubin, revealed reduction of epileptiform discharges in PTZ-treated zebrafish larvae [ 144 ] 14 Jatropha curcas L AQ PTZ & MES Male albino mice (25–30 g) 100–400 Protected the mice against the MES-induced convulsion. While at 400 mg/kg, it significantly protected the mice against ...…”

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

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Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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Epilepsy is a common central nervous system (CNS) disorder that affects 50 million people worldwide. Patients with status epilepticus (SE) suffer from devastating comorbidities and a high incidence of mortalities. Antiepileptic drugs (AEDs) are the mainstream treatment options for the symptomatic relief of epilepsy. The incidence of refractory epilepsy and the dose-dependent neurotoxicity of AEDs such as fatigue, cognitive impairment, dizziness, attention-deficit behavior, and other side effects are the major bottlenecks in epilepsy treatment. In low- and middle-income countries (LMICs), epilepsy patients failed to adhere to the AEDs regimens and consider other options such as complementary and alternative medicines (CAMs) to relieve pain due to status epilepticus (SE). Plant-based CAMs are widely employed for the treatment of epilepsy across the globe including Ethiopia. The current review documented around 96 plant species (PS) that are often used for the treatment of epilepsy in Ethiopia. It also described the in vivo anticonvulsant activities and toxicity profiles of the antiepileptic medicinal plants (MPs). Moreover, the phytochemical constituents of MPs with profound anticonvulsant effects were also assessed. The result reiterated that a lot has to be done to show the association between herbal-based epilepsy treatment and in vivo pharmacological activities of MPs regarding their mechanism of action (MOA), toxicity profiles, and bioactive constituents so that they can advance into the clinics and serve as a treatment option for epilepsy.

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Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

Section: Pharmacological Evidence Of Reported Medicinal Plantsmentioning

confidence: 99%

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Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Birhan

2022

Chin Med

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“…As a folk medicine, Chipilin extracts are used to treat several health conditions. ,, The antimicrobial, antifungal, insecticidal, and anticancer activities of acetonic and methanolic extracts of Chipilin leaves and branches have been reported. − As an ethnomedicine, Chipilin is recommended as an evening meal to treat insomnia and anxiety. ,− However, its pharmacological activity as a sedative agent is not well-known; in addition, little is known about the compounds that are present in Chipilin extracts that could be related to this action. Thus, further research is needed. , On the other hand, the selection of an efficient extraction method is decisive for the identification of novel phytochemicals. Indeed, the identification of new sources of bioactive compounds and their functions has a growing demand in the healthcare, pharmaceutical, food, and beverage industries…”

Section: Introductionmentioning

confidence: 99%

Toxicological and Sedative Effects of Chipilin (Crotalaria longirostrata) Leaf Extracts Obtained by Maceration and Supercritical Fluid Extraction

Hernández-Reyes,

Guzmán-Albores,

De León-Rodríguez

et al. 2024

ACS Omega

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Chipilin (Crotalaria longirostrata) is consumed as a vegetable in the preparation of traditional dishes. As a folk medicine, Chipilin extracts are used as a hypnotic and sedative agent; however, there are few reports that support these uses. This study aimed to characterize the compounds present in Chipilin leaf extracts and to investigate their sedative effect using zebrafish as an in vivo model. Extracts were obtained by maceration with water (H 2 O), ethanol (EtOH), and EtOH-H 2 O, while oleoresin was obtained by supercritical fluid extraction (SFE). Total phenolic and flavonoid contents were quantified by colorimetric methods. Phytochemical constituents were identified by gas chromatography−mass spectrometry (GC-MS) analysis. The chronic and acute toxicities of Chipilin extracts were tested in zebrafish embryos and larvae, respectively. Chipilin sedative effect was tested by the larvae response to dark−light−dark transitions. EtOH-H 2 O extracts had the highest value of total phenolics (5345 ± 5.1 μg GAE/g), followed by water and oleoresin (1815 ± 5.1 and 394 ± 5.1 μg GAE/g, respectively). In water extracts were identified the alkaloid trachelanthamidine, 1,2β-epoxy-and the alkyl ketone 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, while oleamide, αmonostearin, and erucamide were detected in all samples except in water extracts. Oleoresin extract had the lowest embryotoxicity (LC 50 = 4.99 μg/mL) and the highest sedative effects. SFE is a green alternative to obtain Chipilin extracts rich in erucamide, an endocannabinoid analogue, which plays an important role in the development of the central nervous system and in modulating neurotransmitter release.

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“…Several studies of T. lucida have been focused mainly on pharmacological activities and phytochemical isolation and identification [ 12 , 13 ]. Additionally, high-performance liquid chromatography–diode array detection (HPLC–DAD) coupled with ultraviolet (UV) has been commonly used in the identification of coumarins from T. lucida extracts [ 1 , 3 , 5 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model

Santibáñez

Herrera-Ruíz

González-Cortazar

et al. 2022

Plants

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Tagetes lucida has been widely used as a folk remedy in illnesses associated with the central nervous system and inflammatory ailments. Among the chemical compounds that stand out in the plant against these conditions are coumarins, such as 7-O-prenylscopoletin (PE), scoparone (SC), dimethylfraxetin (DF), herniarin (HR), and 7-O-prenylumbelliferone (PU), considered potential anti-neuroinflammatory compounds. Therefore, the relationship between the therapeutic effect and the dose can be evaluated through pharmacokinetic–pharmacodynamic (PK–PD) studies under a model of neuroinflammation induced by lipopolysaccharide (LPS). Nonetheless, accomplishing those studies requires an accurate and robust analytical method for the detection of these compounds in different biological matrices of interest. Due to the above, in the present study, a bioanalytical method was established by HPLC–DAD-UV for the simultaneous quantification of the coumarins present in the hexane extract of T. lucida, which was able to determine the temporal concentration profiles of each of the coumarins in the plasma, brain, kidney, and spleen samples of healthy and damaged mice. Coumarins showed an increase in plasma concentrations of up to three times in the neuroinflammation model, compared to healthy mice, so it was possible to quantify the therapeutic agents in the main target organ, the brain. The ability of compounds to cross the blood–brain barrier is an advantage in the treatment of diseases associated with neuroinflammation processes that can be studied in future PK–PD evaluations.

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Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview

Cited by 16 publications

References 214 publications

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phytochemistry

Toxicological and Sedative Effects of Chipilin (Crotalaria longirostrata) Leaf Extracts Obtained by Maceration and Supercritical Fluid Extraction

Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model

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