Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals

Andrade, Casimiro de; Gomes, Nelson G.M.; Duangsrisai, Sutsawat; Andrade, Paula B.; Pereira, David M.; Valentão, Patrı́cia

doi:10.1016/j.jep.2020.113177

Cited by 45 publications

(27 citation statements)

References 429 publications

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“…1 , 2 DM is associated with several deteriorating complications including neuropathy, nephropathy, retinopathy, cardiovascular diseases amongst several others, which significantly affects the quality of life of diabetic patients. 3 , 4 Diabetic nephropathy (DN) is one of the leading and most frequently encountered complication in DM and it significantly contributes to the mortality rates in diabetic patients. 5 , 6 The clinical features characterizing DN include thickening of the basement membrane, extracellular matrix accumulation, as well as tubular and glomerular hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy

Cao¹,

Li²,

Famurewa³

et al. 2021

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Background: Nephropathy is a frontline complication of diabetes mellitus (DM) associated with impaired redox-inflammatory networks. The study investigated the antidiabetic and nephroprotective potentials of PCR against diabetic nephropathy (DN) in rats. Methods: DN was induced in rats using a combination of a high fructose solution for 4 weeks and an intraperitoneal injection of streptozotocin (35 mg/kg). Diabetic rats were treated with PCR (100 and 400 mg/kg body weight) for 8 weeks. Serum biochemical parameters as well as renal oxidative stress parameters, proinflammatory cytokines, Western blot and histopathological analyses were evaluated. Results: There were significant increases in fasting blood glucose, urinary albumin, serum creatinine, blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), and lowdensity lipoproteins (LDL-C) levels in diabetic rats compared to the non-diabetic control rats. DM-induced DN prominently depressed renal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, whereas renal malondialdehyde (MDA) level was markedly increased. Furthermore, renal inflammatory cytokines, IL-1β, IL-6, TNF-α and TGF-β, were considerably elevated compared to non-diabetic control rats. Additionally, DN rats showed a significant increase in renal fibrosis, as evidenced by increased expression of TGF-β1, collagen-1, fibronectin and alpha-smooth muscle actin (α-SMA) in the kidneys. Histopathological lesions were consistent with tubule thickening and glomerular hypertrophy. Conversely, PCR treatment exerted significant attenuation of hyperglycemia, dyslipidemia and renal oxidative stress indicators. The increased renal levels of IL-1β, IL-6, TNF-α and TGF-β were also notably reversed dose-dependently with alleviation of nephropathic histology. Furthermore, PCR reduced the expression of α-SMA, fibronectin, collagen-1 and TGF-β1 in the renal tissues. Conclusion:Our results suggest that PCR displayed antidiabetic and nephroprotective effects against DN by impeding oxidative stress and inflammation. As such, PCR has potentials as a food supplement for alleviating renal dysfunction caused by diabetes.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy

Cao¹,

Li²,

Famurewa³

et al. 2021

DMSO

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“…There are already enough reviews on the use of natural products from herbal preparations in the treatment of DM including systematic reviews and meta-analyses ( Andrade et al, 2020 ; Bilal et al, 2018 ; Jacob and Narendhirakannan, 2019 ; Kooti et al, 2016 ; Kumar et al, 2021 ; Pang et al, 2019 ; Zheng et al, 2020 ; Zhou et al, 2021 ). However, only a few of the numerous antidiabetic herbs have been clinically evaluated for their efficacy and safety, and their success in ameliorating diabetes has been attributed to their phytochemical constituents such as phenolic compounds, flavonoids, terpenoids, and coumarins ( Kumar et al, 2021 ).…”

Section: Herbal Medications and Natural Products In The Management Of...mentioning

confidence: 99%

Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges

Yusuf

Zhang

et al. 2022

Phytomedicine Plus

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“…Previous research found that TTM recipes in Northeastern and Southern Thailand, rich in polyphenols and tannins, could reduce postprandial hyperglycemia by inhibiting α-glucosidase and α-amylase enzymes [13]. The TTM in North and Northeastern Thailand, rich in saponin and reducing sugar, reduce postprandial hyperglycemia by inhibiting α-glucosidase activity [21]. The previous research points out that numerous species have long been used in Northeastern Thailand, but their underlying anti-diabetic activities, as well as their phytochemical constituents, have not yet been identified [13,22].…”

Section: Introductionmentioning

confidence: 99%

“…Plant polyphenols (e.g., flavonoids, xanthones, tannic acids) can exhibit the anti-α-amylase and anti-α-glucosidase enzymes, which result in a reduction of the postprandial hyperglycemia [10,11,[17][18][19][20]. Traditional Thai medicines (TTM) have long been used over decades for the treatment of diabetes mellitus [21]. Previous research found that TTM recipes in Northeastern and Southern Thailand, rich in polyphenols and tannins, could reduce postprandial hyperglycemia by inhibiting α-glucosidase and α-amylase enzymes [13].…”

Section: Introductionmentioning

confidence: 99%

Machine Learning and In Vitro Chemical Screening of Potential α-Amylase and α-Glucosidase Inhibitors from Thai Indigenous Plants

et al. 2022

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Diabetes mellitus is a major predisposing factor for cardiovascular disease and mortality. α-Amylase and α-glucosidase enzymes are the rate-limiting steps for carbohydrate digestion. The inhibition of these two enzymes is clinically used for the treatment of diabetes mellitus. Here, in vitro study and machine learning models were employed for the chemical screening of inhibiting the activity of 31 plant samples on α-amylase and α-glucosidase enzymes. The results showed that the ethanolic twig extract of Pinus kesiya had the highest inhibitory activity against the α-amylase enzyme. The respective ethanolic extract of Croton oblongifolius stem, Parinari anamense twig, and Polyalthia evecta leaf showed high inhibitory activity against the α-glucosidase enzyme. The classification analysis revealed that the α-glucosidase inhibitory activity of Thai indigenous plants was more predictive based on phytochemical constituents, compared with the α-amylase inhibitory activity (1.00 versus 0.97 accuracy score). The correlation loading plot revealed that flavonoids and alkaloids contributed to the α-amylase inhibitory activity, while flavonoids, tannins, and reducing sugars contributed to the α-glucosidase inhibitory activity. In conclusion, the ethanolic extracts of P. kesiya, C. oblongifolius, P. anamense, and P. evecta have the potential for further chemical characterization and the development of anti-diabetic recipes.

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Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals

Cited by 45 publications

References 429 publications

Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy

Antidiabetic and Nephroprotective Effects of Polysaccharide Extract from the Seaweed Caulerpa racemosa in High Fructose-Streptozotocin Induced Diabetic Nephropathy

Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges

Machine Learning and In Vitro Chemical Screening of Potential α-Amylase and α-Glucosidase Inhibitors from Thai Indigenous Plants

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