Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

Abstract

The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke side effects and health issues, which heightens the need for molecules from plants and other natural resources under discovery as potential methods of replacing synthetic compounds. In traditional medicinal therapies, several plant extracts and phytochemicals have been reported to impart remedial effects as better alternatives. Murraya koenigii (M. koenigii) belongs to the Rutaceae family, which is commonly used as a medicinally important herb of Indian origin in the Ayurvedic system of medicine. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and pharmacological effects. These include antioxidant, antidiabetic, anti-inflammatory, antitumor, and neuroprotective activities. The present review provides insight into the major components of M. koenigii and their pharmacological activities against different pathological conditions. The review also emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigii and its derivatives as potent therapeutic agents.

Hybrid Drying of Murraya koenigii Leaves: Energy Consumption, Antioxidant Capacity, Profiling of Volatile Compounds and Quality Studies

“…M. koenigii leaves contain several bioactive compounds that possess anti-tumour, antioxidant, anti-inflammatory and hypoglycemic properties [7]. Essential oils, which can be found in the leaves of M. koenigii, are significant contributors to antioxidant activity [8][9][10]. However, the proper preservation of these pharmacological properties and their corresponding bioactive compounds through the processing of herbal plants remains challenging.…”

In-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal

“…Bergenia pacumbis (Saxifragaceae) is commonly called as 'Pakhanved' and used to cure diarrhea, dysentery, vomiting, fever, cough, kidney problems, cold, urinary problems, and indigestion [32]. Murraya koenigii (Rutaceae) is commonly called as 'Kadipatta'; traditionally used to cure skin diseases, stomach problems, body aches, dental problem, and urinary tract infection [33] and have antimicrobial, antioxidant, anticancer, antiinflammatory, wound healing, hepatoprotective, antifungal, neuroprotective, and antidiabetic activities [34].…”

Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology

“…Excessive production of ROS results in apoptotic cell death, which can lead to the onset of various diseases and accelerate human aging [ 69 ]. It is beneficial that various chemical components sourced from plants can be used as potential antioxidants, and are considered to be promising therapeutic agents for the prevention of free-radical formation in the human body and for the treatment of various diseases, including cancer, cardiovascular disorders, neurodegenerative disorders, and other conditions [ 70 ].…”

“…Cells treated with synthesized Ag-NPs at 25 µg/mL displayed significant increases in ROS production, reduction in cell migration, and cell apoptosis in both cell lines. Moreover, synthesized Ag-NPs treatment resulted in significant modulation of the EGFR/p38 expressions in A549 cells [ 70 ]. Elsewhere, Lee et al evaluated the proapoptotic activities of ethanol extracts of D. morbifera stem bark on human leukemia U937 cells.…”