Medicinal signaling cells: A potential antimicrobial drug store

Khatibi, Seyed Mahdi Hosseiniyan; Kheyrolahzadeh, Keyvan; Saadat, Yalda Rahbar; Vahed, Sepideh Zununi

doi:10.1002/jcp.29728

Cited by 21 publications

(17 citation statements)

References 135 publications

(221 reference statements)

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“…A series of studies led to the current hypothesis that MSC treatment may in future be an effective strategy for severe pneumonia [86]. Thus far, antibacterial effects from MSCs have been reported [11][12][13]84,[87][88][89][90][91], for instance their role in bacterial clearance of MSCs-derived AMPs that directly boosts the innate immune response [16]. AMPs and MSCs share the ability to fight infections through direct microbicidal properties and/or by modulating the immune responses.…”

Section: Mscs As Source Of Antibiotic-free Nanomaterialsmentioning

confidence: 99%

“…MSCs can transfer to the injured cells factors restraining injury and leading to tissue regeneration. MSCs can interact with the immune system and prevent infection via direct and indirect mechanisms [11]. In particular, the antimicrobial features are linked to paracrine release of several antimicrobial peptides (AMPs), with broad antibacterial properties, and specific extra cellular vesicles (EVs) secretion, including immunomodulatory factors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome

Marrazzo

Pizzuti

Zia³

et al. 2021

Antibiotics

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Antibiotic resistance is creating enormous attention on the development of new antibiotic-free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are the most promising candidates in current clinical trials and included in several cell-therapy protocols. Together with the well-known immunomodulatory and regenerative potential of the MSC secretome, these cells have shown direct and indirect anti-bacterial effects. However, the low reproducibility and standardization of MSCs from different sources are the current limitations prior to the purification of cell-free secreted antimicrobial peptides and exosomes. In order to improve MSC characterization, novel label-free functional tests, evaluating the biophysical properties of the cells, will be advantageous for their cell profiling, population sorting, and quality control. We discuss the potential of emerging microfluidic technologies providing new insights into density, shape, and size of live cells, starting from heterogeneous or 3D cultured samples. The prospective application of these technologies to studying MSC populations may contribute to developing new biopharmaceutical strategies with a view to naturally overcoming bacterial defense mechanisms.

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Section: Mscs As Source Of Antibiotic-free Nanomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome

Marrazzo

Pizzuti

Zia³

et al. 2021

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Mesenchymal stem cells (MSCs) can interact with the immune system to prevent infection through both direct and indirect mechanisms [145]. MSCs, exosomes secreted by these cells can be used as complementary antimicrobial agents, as a substitute for or in combination with antibiotics under specific physiological conditions or specific priming conditions [146].…”

Section: Anti-inflammatory and Antimicrobial Vesiclesmentioning

confidence: 99%

Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives

Liu

Dupuy

et al. 2021

IJMS

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Exosomes are nano-sized vesicles secreted by most cells that contain a variety of biological molecules, such as lipids, proteins and nucleic acids. They have been recognized as important mediators for long-distance cell-to-cell communication and are involved in a variety of biological processes. Exosomes have unique advantages, positioning them as highly effective drug delivery tools and providing a distinct means of delivering various therapeutic agents to target cells. In addition, as a new clinical diagnostic biomarker, exosomes play an important role in many aspects of human health and disease, including endocrinology, inflammation, cancer, and cardiovascular disease. In this review, we summarize the development of exosome-based drug delivery tools and the validation of novel biomarkers, and illustrate the role of exosomes as therapeutic targets in the prevention and treatment of various diseases.

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“…Notably, hypoxia priming of MSCs induces autophagy [117], increases microvesicles and growth factors release [118,119], upregulates chemokine-receptors expression, decreases cellular senescence and apoptosis, and promotes higher retention in vivo and greater therapeutic efficacy [120]. Therefore, new strategies to improve antiviral MSC properties should be developed for production of more robust MSC-based products to treat patients with viral infection diseases, including COVID-19 [116,121,122].…”

Section: Future Directions Of Msc-based Therapies For Covid-19 and Otmentioning

confidence: 99%

Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19

Rocha

Oliveira

Noronha

et al. 2020

Stem Cell Rev and Rep

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Mesenchymal stromal cells (MSCs) constitute a heterogeneous population of stromal cells with immunomodulatory and regenerative properties that support their therapeutic use. MSCs isolated from many tissue sources replicate vigorously in vitro and maintain their main biological properties allowing their widespread clinical application. To date, most MSC-based preclinical and clinical trials targeted immune-mediated and inflammatory diseases. Nevertheless, MSCs have antiviral properties and have been used in the treatment of various viral infections in the last years. Here, we revised in detail the biological properties of MSCs and their preclinical and clinical applications in viral diseases, including the disease caused by the severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) infection (COVID-19). Notably, rapidly increasing numbers of MSC-based therapies for COVID-19 have recently been reported. MSCs are theoretically capable of reducing inflammation and promote lung regeneration in severe COVID-19 patients. We critically discuss the rationale, advantages and disadvantages of MSC-based therapies for viral infections and also specifically for COVID-19 and point out some directions in this field. Finally, we argue that MSC-based therapy may be a promising therapeutic strategy for severe COVID-19 and other emergent respiratory tract viral infections, beyond the viral infection diseases in which MSCs have already been clinically applied.

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Medicinal signaling cells: A potential antimicrobial drug store

Cited by 21 publications

References 135 publications

Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome

Microfluidic Tools for Enhanced Characterization of Therapeutic Stem Cells and Prediction of Their Potential Antimicrobial Secretome

Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives

Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19

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