Medicinal Significance of Novel Coumarins: A Review

Abstract

Coumarone is a chemical compound found in many plants. Coumarone having diverse pharmacological properties popularly known as an antimicrobial, Analgesic anti-inflammatory, Anticancer, Antiviral, anticoagulant, antihypertensive, anticonvulsant, antihyperglycemic, antioxidant, activities. Coumarone was also observed in all green color veggies, and also in fruits and their seeds, dark coffee, tea leafs, further it is used for herbal remedies due to having less toxicity, very cheaper. The most useful method for the synthesis of Coumarone is from phenol and ethyl acetate and also by using catalyst. In this paper we tried to update the observations of authors towards the biological and medicinal significance of novel the natural and synthetic coumarone derivatives.

Purification of Bioactive Compound from Endophytes Bacillus sp. RD26 of Phyllanthus amarus Schum. et Thonn

“…Additionally, pyrimidine derivatives have been identified to have properties, which were similar to those of antibiotics, such as: bacimethrin (5-hydroxymethyl-2-methoxypyrimidine-4-amine) derivative is effective against some infections caused by staphylococci. Cytosine derivatives has been reported to be resistant against mycobacteria and some Gram-positive and Gram-negative bacteria [32]. Additionally, uracil derivatives also had the anti-oxidant ability based on the assay of DPPH free radical scavenging (5aminouracil (IC50: 3 mg/mL), 5-amino-6-methyluracil (IC50: 5 mg/mL), and 5-hydroxy-6-methyluracil (IC50: 15 mg/mL) [34].…”

Advances in the Solid-Phase Synthesis of Pyrimidine Derivatives

“…agonistic, mitotic kinesin inhibiting, antibacterial, fungicidal, etc. 70 Dankers et al reported two conventional methods for the modification of peptides by ureidopyrimidinone (UPy) moieties on the solid support. 71 In the first method, peptides were modified with UPy units at the N-terminal amino acid.…”

Photosynthesis of 3-Alkylated Coumarins from Carboxylic Acids Catalyzed by a Na2S-Based Electron Donor–Acceptor Complex

“…Coumarin represents a core structural motif which is widely present in natural products and synthetic pharmaceuticals . Therefore, their synthesis and functionalization have given rise to much interest from the synthetic community over the past decades .…”