Medicinal Treatment to Equine Gastrointestinal Dysfunctions

Sasaki, Naoki; Yamada, Hiroyuki; Hara, Shigeo

doi:10.1294/jes.14.37

Cited by 3 publications

(4 citation statements)

References 56 publications

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“…In the small intestine, cecum, right ventral colon and right dorsal colon, an increase in maximum amplitude was observed for about 1-4 hr during which time feeding took place. This is a consequence similar to the report that employed a force transducer [19,21], and it is thought that the EIG's maximum amplitude reflects stomach colon contraction during the feeding [19,23]. Because the fluctuations in the maximum amplitude express the fluctuations in digestive tract myoelectric activity and contractile motility, it was thought that the diagnosis of gastrointestinal dysfunction and assessment of the therapeutic effect could be possible based on the maximum amplitude of the EIG.…”

Section: E I G M E a S U R E M E N T S W E R E P E R Fo R M E D W I Tsupporting

confidence: 61%

“…Gastrointestinal dysfunction with gastrointestinal motility disorder exists as a background factor of acute abdominal disorder in the horse [23]. It is thought that in order to effectively treat gastrointestinal dysfunction, it should be diagnosed at an early stage.…”

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confidence: 99%

“…It is thought that in order to effectively treat gastrointestinal dysfunction, it should be diagnosed at an early stage. The analysis of equine digestive motility which provides useful data for digestive motility has been studied employing electromyograms [20,21] and strain gauge force transducer [11,16,23], but both these methods require surgery [7,23]. No measurement and analysis that is applicable to the horse has been established so far.…”

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confidence: 99%

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Clinical Applications of Electrointestinography in the Horse

Sasaki

Lee

Ayukawa

et al. 2004

JES

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It is thought that in order to effectively treat gastrointestinal dysfunction, it should be detected at an early stage. The present study aimed to observe the movement via Electrointestinography (EIG) in the small intestine, cecum, right ventral colon and right dorsal colon, and to examine the procedure for assessing gastrointestinal function. Seven healthy thoroughbred horses were used. They were allowed food twice a day. EIG was measured at ten-minute intervals over a 24 hr period, and running spectral analysis was used. As a result, it was clear that EIG could non-invasively assess gastrointestinal function by setting the cutoff value of the frequency band to 1.8-12.0 cpm for a part of the digestive tract which is in a comparatively fixed position. The running spectral analysis could be used to visually interpret the change in the EIG power. In the small intestine, cecum, right ventral colon and right dorsal colon, a significant increase was observed for about 1-4 hr during which feeding took place at the maximum amplitude and the total power of the EIG wave. Because 3 cpm of the total power could be influenced by artifacts, analysis at 6 cpm is recommended, when the total power was assumed to be an indicator. In conclusion, it was considered capable of effectively detecting two indicators of 6 cpm of the total power and maximum amplitude for assessing change in the digestive tract voltage in medical practice.

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Section: E I G M E a S U R E M E N T S W E R E P E R Fo R M E D W I Tsupporting

confidence: 61%

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confidence: 99%

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confidence: 99%

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Clinical Applications of Electrointestinography in the Horse

Sasaki

Lee

Ayukawa

et al. 2004

JES

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“…A high incidence of digestive disorders has been reported in horses with abnormal function of the digestive tract [19], and regulation of the tract motility was of importance in its treatment [20]. Recently, mosapride, a benzamide derivative [9,15], was developed as a gastroprokinetic agent [13,25,27,28].…”

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Effects of Orally Administrated Mosapride, a 5-HT4 Receptor Agonist on the Digestive Tract of Horses

Sasaki

Lee

Ayukawa

et al. 2004

JES

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The effects of mosapride, a 5-hydroxytryptamine 4 (5-HT 4) receptor agonist, on the motility of horse small intestine were examined by means of electrointestinography (EIG). Six adult healthy thoroughbreds were used, in which EIG signals from the small intestine were measured by a Degetorappar EGG system. Mosapride, dissolved in 200 ml water, was orally administered at a dose of 2 mg/kg. The total power of EIG signals at a frequency band of 3 cpm was 419.1 ± 122.0 (µV) 2 × cpm (n=6) before, and 2,093.6 ± 850.0 (µV) 2 × cpm (n=6) after the drug administration, the latter mean value being significantly greater than the former. This result suggests that mosapride has a prokinetic action on the motility of horse small intestine.

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