Medicinal Uses of Hematopoietic Growth Factors in Neonatal Medicine

Christensen, Robert D.

doi:10.1007/164_2019_261

Handbook of Experimental Pharmacology

2019

DOI: 10.1007/164_2019_261

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Medicinal Uses of Hematopoietic Growth Factors in Neonatal Medicine

Robert D. Christensen

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2023

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Cited by 1 publication

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Neutropenia in Preterm Infants

Chirico

2023

CPR

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Background: The non-specific and antigen-specific components of host defense mechanisms are subject to the adaptation process in the neonate; however, the neutrophil quantitative and qualitative deficiency is one of the most significant causative factors of neonatal-increased vulnerability to infection. Objective: To review the incidence and outcome of neutropenia of unknown cause in preterm infants. Results: The incidence of early and late-onset idiopathic neutropenia of prematurity is significant. Conclusion: The low neutrophil counts respond quickly to G-CSF treatment; however, due to the low probability of septic complications, particularly in the late-onset neutropenia, a deep diagnostic approach and the potential hematopoietic growth factor treatment should be limited to the severe cases, such as a neutrophil count <500/μL, lasting for more than 2 days.

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Neutropenia in Preterm Infants

Chirico

2023

CPR

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Medicinal Uses of Hematopoietic Growth Factors in Neonatal Medicine

Cited by 1 publication

References 114 publications

Neutropenia in Preterm Infants

Neutropenia in Preterm Infants

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