Medicinal Uses of<i>Dioscorea bulbifera</i>-A Review

Niyas, Fathima Mariyam

doi:10.5958/0974-360x.2015.00182.1

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also used as a contraceptive and as an aphrodisiac 20 . Documented studies have reported its antioxidant, anti-diabetic, hematinic, anti-hyperlipidemic, analgesic and antiinflammatory properties [21][22][23][24][25][26][27][28] . Although extracts of Dioscorea bulbifera have been shown to reduce body weight in normolipidemic and hyperlipidemic rat models, the mechanism of action has yet to be evaluated 22,28, 29 .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Serum Lipase as a Mechanism of Action for Anti-Obesity Potentials of Dioscorea bulbifera Extracts on Wistar Rats

Ikete

Chinko

Kalyani

2022

Asian J. Health Sci.

View full text Add to dashboard Cite

Objectives: Dioscorea bulbifera possesses profound therapeutic potential and is commonly used in traditional Indian, African and Chinese medicine. The present study aimed to evaluate the effect of a hydromethanolic extract of Dioscorea bulbifera on the serum lipid profile, lipase, ghrelin, food intake and body weight of high-fat obese Wistar rats. Methods: Thirty (30) male Wistar rats weighing 200 -250 g were used for the study. Obesity was induced using a formulated high-fat diet for six (6) weeks. They were divided into six (6) groups of five (5) rats each. The negative control received distilled water, while the positive control received a standard antihyperlipidemic drug, simvastatin. Obese rats were treated with hydromethanolic extract of Dioscorea bulbifera at 200 mg/kg and 400 mg/kg for a period of two (2) weeks. Results: The results showed significantly decreased serum total cholesterol (TC), low-density lipoprotein (LDL), lipase, fasting blood glucose and body weight of experimental animals compared to the negative control (P < 0.05), while serum high-density lipoprotein (HDL) and ghrelin were found to be significantly higher in experimental animals compared to the negative control (p < 0.05). There was no significant change in the food intake of the animals. Conclusion: The antiobesity potentials of hydromethanolic extracts of Dioscorea bulbifera may be attributable to their ability to reduce lipase activity while attenuating the lipid profile in high-fat obese Wistar rat models. Therefore, this study considers Dioscorea bulbifera as a potential natural anti-obesity agent with possible anti-lipase activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibition of Serum Lipase as a Mechanism of Action for Anti-Obesity Potentials of Dioscorea bulbifera Extracts on Wistar Rats

Ikete

Chinko

Kalyani

2022

Asian J. Health Sci.

View full text Add to dashboard Cite

show abstract

“…El agua es el solvente universal además que, estudios etnobotánicos en Panamá afirman que culturas rurales preparan alimentos con bulbos del género Dioscórea remojados en agua por 12 horas [13]. En los últimos años ha aumentado el número de estudios que afirman tener interés por el desarrollo de bioprocesos para la producción o extracción de compuestos bioactivos de fuentes naturales [10], [14], dadas las posibles aplicaciones de estos compuestos en la industria alimentaria.…”

Section: Introductionunclassified

Evaluación cualitativa de extractos macerados con diferentes solventes para la extracción de glicoalcaloides y flavonoides de Dioscórea bulbifera en condiciones estándar obtenidos en los llanos orientales de Colombia

et al. 2020

View full text Add to dashboard Cite

Se evaluaron cualitativamente diferentes solventes para la extracción de núcleos esteroides y flavonoides en bulbos de Dioscorea bulbifera Salv. Se analizó el bulbo crudo y macerados en agua, aceite y alcohol 40%. La triangulación de las observaciones en las RxSh y RxL-B con un patrón químico definido, un blanco y la prueba experimental evaluó la presencia del núcleo químico. Se estableció por matriz de relaciones que el alcohol tuvo mayor afinidad a compuestos flavonoides y alcaloides detectándose que el 100% de ensayos realizados fue positivo para cada núcleo. Se detectó en un 83% compuestos alcaloides en muestras de bulbo crudo y superior al 70% para flavonoides. El aceite mineral presentó características conservantes del bulbo y resultados negativos para ambos núcleos. Se concluye que el alcoholato con bulbos de D. bulbifera extrae compuestos de núcleos flavonoides y esteroides para emplearse como ingrediente bioactivo para aplicación en diferentes áreas industriales.

show abstract

“…The tuber of Dioscorea bulbifera (DBT), called “Huang-Yao-Zi” in Chinese, has been widely used in traditional Chinese medicine as a remedy for leprosy, tumors and cancers, especially for thyroid diseases. 1,2 Due to analogous morphologies, DBT may be mistakenly eaten as wild yams. 3 Early studies have demonstrated that chronic and excessive use of DBT-containing prescriptions are associated with toxicity in clinical practice, and liver is the main toxic target organ.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of five diterpenoid lactones from Dioscorea bulbifera tubers in zebrafish

et al. 2018

View full text Add to dashboard Cite

Diterpenoid lactones (DLs) have been reported to be the main hepatotoxic constituents in Dioscorea bulbifera tubers (DBT), a traditional Chinese medicinal herb. The acquisition of early information regarding its metabolism is critical for evaluating the potential hepatotoxicity of DLs. We investigated, for the first time, the main metabolites of diosbulbin A (DIOA), diosbulbin C (DIOC), diosbulbin (DIOG), diosbulbin (DIOM) and diosbulbin (DIOF) in adult zebrafish. By using ultra-high performance liquid chromatographyquadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS), 6, 2, 7, 5 and 4 metabolites of DIOA, DIOC, DIOF, DIOM and DIOG were identified in the zebrafish body and the aqueous solution, respectively.Both phase-I and phase-II metabolites were observed in the metabolic profiles and the metabolic pathways involved in hydroxyl reduction, glucuronidation, glutathione conjugation and sulfation. The above results indicated that hepatocytic metabolism might be the major route of clearance for DLs. This study provided important information for the understanding of the metabolism of DLs in DBT.

show abstract

Medicinal Uses ofDioscorea bulbifera-A Review

Cited by 5 publications

References 0 publications

Inhibition of Serum Lipase as a Mechanism of Action for Anti-Obesity Potentials of Dioscorea bulbifera Extracts on Wistar Rats

Inhibition of Serum Lipase as a Mechanism of Action for Anti-Obesity Potentials of Dioscorea bulbifera Extracts on Wistar Rats

Evaluación cualitativa de extractos macerados con diferentes solventes para la extracción de glicoalcaloides y flavonoides de Dioscórea bulbifera en condiciones estándar obtenidos en los llanos orientales de Colombia

Metabolism of five diterpenoid lactones from Dioscorea bulbifera tubers in zebrafish

Contact Info

Product

Resources

About