Medicinal Value of Lagerstroemia Speciosa: An Updated Review

Abstract

Lagerstroemia speciosa (Family: Lythraceae) is native to Asia-tropical and subtropical regions. The phytochemical investigation of Lagerstroemia speciosa leaf and fruit revealed that it contained steroids, terpenoids, glycosides, phenolic compounds, α-amino acids, saponins, starch, alkaloids, carbohydrates, organic acids, flavonoids, reducing sugars, tannins and many other active metabolites. Lagerstroemia speciosa possessed many Pharmacological effects included antimicrobial, antioxidant, anticancer, antidiabetic, hypolipidemic, antiobesity, anti-inflammatory, analgesic, gastrointestinal, diuretic, thrombolytic, cardiovascular, central nervous, inhibition of TNFα production, xanthine oxidase inhibitition, hepatoprotective and nephroprotective effects. The current review discussed the chemical constituents, pharmacological and therapeutic effects of Lagerstroemia speciosa.

Anti-Diabetic Potential of Plant-Based Pentacyclic Triterpene Derivatives: Progress Made to Improve Efficacy and Bioavailability

“…A decrease in fasting and postprandial blood glucose levels in human subjects has been reported to corroborate corosolic acid’s anti-diabetic activity [ 154 , 155 ]. Corosolic acid had the highest activity on α-glucosidase compared to oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, and 23-hydroxyursolic acid [ 156 ].…”

“…This compound (Figure 8a) is known to regulate several biological processes in colorectal, cervical, and ovarian cancer through the activation of kinases and biological oxidative damage [151][152][153]. A decrease in fasting and postprandial blood glucose levels in human subjects has been reported to corroborate corosolic acid's anti-diabetic activity [154,155]. Corosolic acid had the highest activity on α-glucosidase compared to oleanolic acid, arjunolic acid, asiatic acid, maslinic acid, and 23-hydroxyursolic acid [156].…”

Medicinal Plants with neuroprotective effects

“…The extract also showed dose dependent reduction in pain threshold tested by mechanical, cold and thermal hyperalgesia. The extract also showed antioxidant effects [52][53] .…”

SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking

“… 1 The fruits and seeds of Luffa contain various bioactive compounds, such as phenolics, 1 flavonoids, 1 luffins, 2 , 3 sapogenins, 4 and triterpenoids. 5 Luffa possesses wide pharmaceutical activities such as anticancer, 5 anti-inflammatory, 1 anti-HIV-1 (human immunodeficiency virus 1), 2 antioxidants, 6 antifungal, 7 and antibacterial 7 activities. For instance, oleanolic acid isolated from L. cylindrica demonstrated inhibition of NO production at 10 μM in an LPS/IFN‐γ‐induced cell model occurred.…”