Background: Medicolegal deaths refer to sudden deaths or deaths with uncertain/unknown cause. Forensic or medicolegal autopsies are performed to establish the exact cause of death, circumstances of death, identity of deceased and also the manner of death. The present study profiles the trend of manner of medicolegal death cases using forensic autopsy findings and police reports from the law court. Methods: Data on manner of death were obtained by retrospective review of forensic autopsy findings, police/coroner's reports, toxicology and histology reports. Descriptive analysis was done with SPSS (α=0.05). Results: A total of 303 medicolegal autopsies were performed; 114 (37.6%) natural deaths, 185 (61.1%) unnatural deaths and 4 (1.3%) unascertained cases. Out of the 185 unnatural deaths, there were 119 accidental deaths, 59 homicidal deaths and 7 was suicidal. Cardiovascular diseases, road traffic accident (RTA), blunt injury assault and chemical poising were the dominant factors to natural, accidental, homicidal and suicidal deaths respectively. Conclusion: RTA was the major manner of death identified in the study. This study showed that most of the medicolegal death cases in Ghana are due to unnatural causes and mainly accidental.