Medicobiological and genetic studies on alcoholism Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality

Agarwal, D. P.; Goedde, H. W.

doi:10.1007/bf00210227

Cited by 19 publications

(6 citation statements)

References 49 publications

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“…Another important enzyme involved in the biotransformation of ethanol is low k m aldehyde dehydrogenase (ALDH), which is located in the mitochondria of liver cells and its main function is to convert the toxic metabolite acetaldehyde into benign acetate [18,[26][27][28]. The acetate produced during metabolism of ethanol undergoes extra-hepatic metabolism into Acetyl-CoA, which enters the Krebs cycle and is eventually converted into the end products CO 2 and H 2 O [23,29].…”

Section: Alcohol In the Bodymentioning

confidence: 99%

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Jones¹

2010

Forensic Science International

168

115

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Section: Alcohol In the Bodymentioning

confidence: 99%

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Jones¹

2010

Forensic Science International

168

115

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“…It is believed that the ALDH2*2 allele, with reduced enzyme activity, provides protection against the risk of developing alcoholism [108]. In previous reports, nearly half of the East Asian population has the ALDH2*2 allele variant [109], including Han Chinese in Taiwan [108,110], but this allele is rarely found in other ethnic populations.…”

Section: The Drd2 Gene Associated With Aldh2 In Bipolar II Disorder Wmentioning

confidence: 99%

Comorbid Mental Disorders in Anxiety Disorders: Genetic Aspects of Bipolar Disorders and of Ethnicity

Chang¹,

Lee²,

Lu³

2016

New Developments in Anxiety Disorders

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Anxiety disorder (AD) is commonly comorbid with other mental illness. It could be a state or trait, controversially. Evidence for an association between alcoholism and anxiety has emerged from clinical studies of patients with alcoholism, and those of patients with anxiety disorders. Alcohol dependence (or abuse) as well as bipolar disorder (BP) is usually comorbid with anxiety disorder and/or depressive disorder, which often coexist and are difficult to distinguish from one another. However, in Han Chinese population, the comorbidity rate either with alcoholism or bipolar disorder was not reported as much high as reported in Caucasians, this finding of comorbidity between anxiety/depressive disorders and alcohol dependence (or abuse) or/and bipolar disorders, possibly at the genetic level, makes the differentiation of their categorical diagnoses in the association study vitally important. AbbreviationsAD: anxiety disorder ALDH2: aldehyde dehydrogenase 2 ANX/DEP ALC: anxiety/depression alcoholism BDNF: brain-derived neurotrophic factor BP: bipolar disorder DOPAC: 3,4-dihydroxyphenylacetic acid DOPAL: 3,4-dihydroxyphenylacetaldehyde DRD2: dopamine D2 receptor DRD3: dopamine D3 receptor GAD: generalized anxiety disorder PTSD: post-traumatic stress disorder PD: panic disorder OCD: obsession compulsive disorder MAOA: monoamine oxidase A

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“…Der Alkoholmissbrauch ist als Zivilisationskrankheit anzusehen (Agarwal et al 1992). Nach Nikotinkonsum und Bluthochdruck stellt der Alkohol das dritthöchste Risiko für Krankheit und vorzeitigen Tod in Europa dar (Anderson et al 2006).…”

Section: Bei Der Viralen Hepatitis Führen Die Hepatitis B- C-und D-vunclassified

Verlaufsbeobachtung von Patienten mit Anlage eines Transjugulären Intrahepatischen Portosystemischen Shunts (TIPS) zur Beeinflussung des Aszites bei dekompensierter Leberzirrhose

Ballauf¹,

Holle²,

Emmrich³

et al. 2009

Z Gastroenterol

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Medicobiological and genetic studies on alcoholism Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality

Cited by 19 publications

References 49 publications

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Comorbid Mental Disorders in Anxiety Disorders: Genetic Aspects of Bipolar Disorders and of Ethnicity

Verlaufsbeobachtung von Patienten mit Anlage eines Transjugulären Intrahepatischen Portosystemischen Shunts (TIPS) zur Beeinflussung des Aszites bei dekompensierter Leberzirrhose

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