Medikament�se Therapie der tumorbedingten Anorexie

Borghardt, J.

doi:10.1159/000420279

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“…At the time of diagnosis, almost 60 % of head and neck cancer patients present with an advanced stage of disease and only 30 % of these patients can be cured by conventional surgery and radiation [1]. The majority of patients suffer from anorexia and cachexia which entail a poor survival prognosis and a low performance status [2,3]. Intensive treatments such as cisplatin/carboplatin and 5fluorouracil chemotherapy in combination and with or without additional radiation can improve the prognosis of a large number of patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Spleen Peptide Preparation as Supportive Therapy in Inoperable Head and Neck Cancer Patients

Borghardt¹,

Rosien

Görtelmeyer

et al. 2011

Arzneimittelforschung

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Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a phase III randomized, placebo-controlled double-blind study during chemotherapy (cisplatin/carboplatin, 5-fluorouracil) to investigate further the efficacy of this peptide preparation as supportive treatment under chemotherapy. Immunological changes as well as quality of life aspects were examined. Forty patients were included in this study. The peptide preparation had a significant stabilizing effect on the peripheral blood lymphocyte status during chemotherapy cycles (Student t-test, p = 0.05) and tended to stabilize the shift of granulocyte count (Student t-test, p = 0.18). In addition, the group receiving the verum showed a remarkable stabilization of body weight (Mann-Whitney U-test, p = 0.17) during chemotherapy treatment and the generally observed increase of fatigue-inertia during the chemotherapy cycles was significantly reduced (Student t-test, p = 0.01).

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Section: Introductionmentioning

confidence: 99%