Meditation-induced modulation of brain response to transcranial magnetic stimulation

Bodart, Olivier; Fecchio, Matteo; Massimini, Marcello; Wannez, Sarah; Virgillito, Alessandra; Casarotto, Silvia; Rosanova, Mario; Lutz, Antoine; Ricard, Matthieu; Laureys, Steven; Gosseries, Olivia

doi:10.1016/j.brs.2018.08.018

Cited by 14 publications

(9 citation statements)

References 10 publications

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“…PICO questions 1–3 refer to clinical standard (resting state) EEG, PICO questions 4–6 to consciousness paradigms, including high‐density EEG, TMS‐EEG and evoked potentials. Thirty publications were included for final analysis . PICO 1 Can visual analysis of clinical standard EEG differentiate coma and VS/UWS from MCS? …”

Section: Resultsmentioning

confidence: 99%

“…Six studies with 173 patients were deemed suitable for analysis . Relative risk for detection of signs of covert consciousness with TMS‐EEG compared to clinical examination was 5.40 (95% CI 3.29–8.87; P < 0.0001).…”

Section: Resultsmentioning

confidence: 99%

“…Recommendation: It is suggested that TMS‐EEG should be considered for the differentiation between VS/UWS and MCS as part of multimodal assessment ( low evidence, weak recommendation ). Current evidence suggests that TMS‐EEG has a high sensitivity and specificity for the differentiation between VS/UWS and MCS and is likely to play a more important part in the future.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

Kondziella

Bender

Diserens

et al. 2020

Euro J of Neurology

488

392

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show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

Kondziella

Bender

Diserens

et al. 2020

Euro J of Neurology

488

392

View full text Add to dashboard Cite

show abstract

“…Further studies are needed to better understand the potential similarities and differences between these experiences. These differences in terms of phenomenology may be due to different underlying neurophysiological mechanisms specific to each of them (Bodart et al, 2018;.…”

Section: Discussionmentioning

confidence: 99%

The Near-Death Experience Content (NDE-C) scale: Development and psychometric validation

Martial

Simon

Puttaert

et al. 2020

Consciousness and Cognition

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As interest grows in near-death experiences (NDEs), it is increasingly important to accurately identify them to facilitate empirical research and reproducibility among assessors. We aimed (1) to reassess the psychometric properties of the NDE scale developed by Greyson (1983) and ( 2) to validate the Near-Death Experience Content (NDE-C) scale that quantifies NDEs in a more complete way. Internal consistency, construct and concurrent validity analyses were performed on the NDE scale. Based on those results and the most recent empirical evidence, we then developed a new 20-item scale. Internal consistency, explanatory and confirmatory factor, concurrent and discriminant validity analyses were conducted. Results revealed (1) a series of weaknesses in the NDE scale, (2) a 5-factor structure covering relevant dimensions and the very good psychometric properties of the NDE-C scale, including very good internal consistency (Cronbach α=0.85) and concurrent validity (correlations above 0.76). This new reliable scale should facilitate future research.

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“…In line with these previously published methods, we used a real-time Matlab-based Graphical User Interface (GUI) that could visualize the EEG response to single pulses of TMS. Selection of stimulation location was individualized with coil location and angle to elicit the lowest amount of scalp muscle activation with the largest brain response with characteristic frequency of response with each brain area (approximately 25-35Hz for premotor, 15-25Hz for motor, and 5-15Hz for parietal sites) (5,6). For the premotor location, we stimulated at Brodmann area 6, with the center of the TMS coil placed between electrodes F1, Fz, FC1, and FCz.…”

Section: Tms Stimulation Target Selectionmentioning

confidence: 99%

Assessing the Intra- and Inter-Subject Reliability of the Perturbational Complexity Index (PCI) of Consciousness for Three Brain Regions Using TMS-EEG

Caulfield¹,

Mt²,

Jw³

et al. 2020

Preprint

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Background:The perturbational complexity index (PCI) is a useful measure of consciousness that combines transcranial magnetic stimulation (TMS) with electroencephalography (EEG).However, the PCI has not been assessed for reliability between sessions nor is there a clear best stimulation target to acquire a PCI.Objective/Hypothesis: We assessed the reliability of within-subject PCIs between 3 sessions with stimulation over the same premotor, motor, and parietal targets between visits, hypothesizing that we could determine a most reliable TMS-EEG target to acquire PCIs in healthy, conscious adults.Methods: PCIs were acquired for 9 participants (5 women) over 3 sessions within a week. A 64 channel EEG system was used with all electrode impedances ≤ 10kΩ. Premotor, motor, and parietal stimulation targets were identified using a real-time Matlab graphical user interface (GUI). Neuronavigation using an MRI-template brain ensured that every TMS pulse was delivered within 3.0mm and 5° of the stimulation target.Results: Premotor, motor, and parietal PCIs all had significant PCIs (all p < 0.05). However, parietal and motor PCIs had excellent reliability (ICCs = 0.927 and 0.857 respectively) whereas premotor PCIs had good reliability (ICC = 0.737). PCIs were similar between brain sites within each subject in a single visit, but with only a moderate effect (p = 0.024, ICC = 0.480). PCIs on a group level did not differ between brain sites (p = 0.589). Conclusions:The PCI is a reliable measure over this timeframe within each subject for single brain targets. PCIs for parietal and motor sites are most similar between visits. Due to only moderate similarity between PCIs from three brain sites within each session, PCIs should be acquired over at least two brain sites, with parietal and motor regions as the top candidates.

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Meditation-induced modulation of brain response to transcranial magnetic stimulation

Cited by 14 publications

References 10 publications

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

The Near-Death Experience Content (NDE-C) scale: Development and psychometric validation

Assessing the Intra- and Inter-Subject Reliability of the Perturbational Complexity Index (PCI) of Consciousness for Three Brain Regions Using TMS-EEG

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