Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; The Attica study

Tzima, Natalia; Pitsavos, Christos; Panagiotakos, Demosthenes B.; Skoumas, John; Zampelas, Antonis; Chrysοhoou, Christina; Stefanadis, Christodoulos

doi:10.1186/1476-511x-6-22

Cited by 96 publications

(83 citation statements)

References 33 publications

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“…The Mediterranean diet has received attention for ameliorating cardiovascular risk in observational studies (10,11) and randomized trials (12,13). Purported mechanisms of action, including improvements in BP (14,15), lipid profile (15), endothelial function (16), and inflammation (17), may benefit the kidney as well. Few studies have examined relationships between a Mediterranean-style diet and kidney function, but their results are inconclusive due to cross-sectional study design (18)(19)(20)(21), limited demographics (6,18), or short duration (22).…”

Section: Introductionmentioning

confidence: 99%

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

Khatri¹,

Moon

Scarmeas

et al. 2014

Clinical Journal of the American Society of Nephrology

116

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Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknown whether a Mediterranean diet, which has been associated with improved cardiovascular risk, is associated with change in kidney function.Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnaire was extrapolated into a previously used 9-point scoring system (MeDi). The primary outcome was incident eGFR,60 ml/min per 1.73 m 2 using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline ($2.5 ml/min per 1.73 m 2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors.Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m 2 . Incident eGFR,60 ml/min per 1.73 m 2 developed in 14% . In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR,60 ml/min per 1.73 m 2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98).Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR,60 ml/min per 1.73 m 2 and upper quartile of eGFR decline in a multiethnic cohort.

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Section: Introductionmentioning

confidence: 99%

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

Khatri¹,

Moon

Scarmeas

et al. 2014

Clinical Journal of the American Society of Nephrology

116

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show abstract

“…The ratio of MUFAs : SFAs fat ratio is high > 2 [195]. This diet pattern is associated with reduction in total and LDL-cholesterol, and also a significant effect on triglycerides and VLDL concentrations, and a small positive or no effect on HDL-cholesterol [196][197][198][199] and improves dyslipidemia in dislipidemic patients [200]. This diet also includes antioxidant vitamins and phenolic compounds, and therefore reduces levels of circulating oxidized LDL and increases total antioxidant capacity [201].…”

Section: Dietary Patternmentioning

confidence: 98%

Nutritional Management of Disturbances in Lipoprotein Concentrations

Hosseinpour-Niazi¹,

Mirmiran²,

Azizi³

2012

Lipoproteins - Role in Health and Diseases

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“…PUFAs have been associated with IR [50--52] while cis--MUFAs and n--3 PUFAs are largely associated with improved insulin sensitivity [43,60,198,199]. However, relationships between distinct FAs and markers of IR have not been investigated and compared across a number of ethnicities.…”

Section: Chapter 3 Rationale and Objectivementioning

confidence: 99%

Serum fatty acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty acid profiles

Zulyniak

2014

Appl. Physiol. Nutr. Metab.

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Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; The Attica study

Abstract: Background: We aimed to investigate if overweight and obese adults "close" to Mediterranean diet present better insulin, lipids profile and better pressure levels, compared to individuals close to a more Westernized diet.

Cited by 96 publications

References 33 publications

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort

Nutritional Management of Disturbances in Lipoprotein Concentrations

Serum fatty acid profiling within distinct lipid fractions provides a more robust indicator of insulin resistance in humans than total triglyceride and fatty acid profiles

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