Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention

Almanza-Aguilera, Enrique; Cano, Ainara; Gil-Lespinard, Mercedes; Burguera, Nerea; Zamora-Ros, Raul; Agudo, Antonio; Farràs, Marta

doi:10.1016/j.semcancer.2023.08.001

Cited by 19 publications

(7 citation statements)

References 241 publications

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“…Currently, as far as our knowledge goes, there is substantial evidence in the role of obesity and poor physical activity in increasing meningioma risk [ 10 , 52 – 54 ]: obesity is associated with the development of type II diabetes and so higher circulating levels of IGF-1 and insulin, which can pass through the blood–brain barrier and thus promote, through several mechanism, meningioma’s growth and progression [ 52 – 57 ] Moreover, a higher concentration of adipose tissue is deemed to be associated with a major blood concentration of estrogens, which could therefore lead to the development and progression of meningiomas. Interestingly, this awareness could partially explain the higher incidence of these tumors among the female gender [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review

Costanzo,

Simonetta,

Musso

et al. 2023

Neurosurg Rev

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Several studies through the years have proven how an unhealthy nutrition, physical inactivity, sedentary lifestyle, obesity, and smoking represent relevant risk factors in cancer genesis. This study aims to provide an overview about the relationship between meningiomas and food assumption in the Mediterranean diet and whether it can be useful in meningioma prevention or it, somehow, can prevent their recurrence. The authors performed a wide literature search in PubMed and Scopus databases investigating the presence of a correlation between Mediterranean diet and meningiomas. The following MeSH and free text terms were used: “Meningiomas” AND “Diet” and “Brain tumors” AND “diet.” Databases’ search yielded a total of 749 articles. After duplicate removal, an abstract screening according to the eligibility criteria has been performed and 40 articles were selected. Thirty-one articles were excluded because they do not meet the inclusion criteria. Finally, a total of 9 articles were included in this review. It is widely established the key and protective role that a healthy lifestyle and a balanced diet can have against tumorigenesis. Nevertheless, studies focusing exclusively on the Mediterranean diet are still lacking. Thus, multicentric and/or prospective, randomized studies are mandatory to better assess and determine the impact of food assumptions in meningioma involvement.

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Section: Discussionmentioning

confidence: 99%

Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review

Costanzo,

Simonetta,

Musso

et al. 2023

Neurosurg Rev

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“…The Mediterranean diet is currently recognized as a healthy diet, characterized by high intakes of vegetables, legumes, fresh fruits, unrefined grains, nuts, and olive oil; moderate intakes of fish and dairy products; low consumption levels of red meat; and moderate consumption levels of alcohol. There is substantial evidence that Mediterranean dietary patterns are negatively associated with cancer risk [ 155 ].…”

Section: Perspectivesmentioning

confidence: 99%

CD36: The Bridge between Lipids and Tumors

Zhou,

Su,

et al. 2024

Molecules

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It has been found that the development of some cancers can be attributed to obesity, which is associated with the excessive intake of lipids. Cancer cells undergo metabolic reprogramming, shifting from utilizing glucose to fatty acids (FAs) for energy. CD36, a lipid transporter, is highly expressed in certain kinds of cancer cells. High expressions of CD36 in tumor cells triggers FA uptake and lipid accumulation, promoting rapid tumor growth and initiating metastasis. Meanwhile, immune cells in the tumor microenvironment overexpress CD36 and undergo metabolic reprogramming. CD36-mediated FA uptake leads to lipid accumulation and has immunosuppressive effects. This paper reviews the types of FAs associated with cancer, high expressions of CD36 that promote cancer development and progression, effects of CD36 on different immune cells in the tumor microenvironment, and the current status of CD36 as a therapeutic target for the treatment of tumors with high CD36 expression.

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“…The potential for reducing the risk of cancer through the MD has been extensively studied due to its profile of anti-inflammatory foods, including antioxidants, polyphenols, and omega-3 fatty acids (FAs). Its antioxidants and polyphenols are associated with an antineoplastic effect 22 .…”

Section: Nutritional Management In Preventionmentioning

confidence: 99%

“…This diet is primarily based on plant-based foods such as fresh fruits, unrefined grains, nuts, whole grains, seafood, olive oil, and low-fat dairy products such as cow's milk and low-fat cheeses. The consumption of wine is permitted, while the consumption of red meat and sugar should be occasional 22 .…”

Section: Nutritional Management In Preventionmentioning

confidence: 99%

Nutrological therapy in oncology: from prevention to nutritional support during treatment

Matos,

Silvestre,

Fernandes

et al. 2024

Rev. Assoc. Med. Bras.

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Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention

Cited by 19 publications

References 241 publications

Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review

Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review

CD36: The Bridge between Lipids and Tumors

Nutrological therapy in oncology: from prevention to nutritional support during treatment

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