Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial

Galilea-Zabalza, Iñigo; Buil‐Cosiales, Pilar; Salas‐Salvadó, Jordi; Toledo, Estefanía; Ortega-Azorín, Carolina; Díez‐Espino, Javier; Vázquez‐Ruiz, Zenaida; Zomeño, María Dolores; Vioque, Jesús; Martínéz, J. Alfredo; Romaguera, Dora; Pérez-Farinós, Napoleón; López‐Miranda, José; Estruch, Ramón; Bueno‐Cavanillas, Aurora; Arós, Fernando; Tur, Josep A.; Tinahones, Francisco J.; Serra‐Majem, Lluís; Marcos‐Delgado, Alba; Ortega‐Calvo, Manuel; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel, Lidia; Delgado-Rodrı́guez, Miguel; Matía, Pilar; Corella, Dolores; Díaz‐López, Andrés; Babió, Nancy; Muñoz, Miguel Ángel; Fitó, Montse; González‐Palacios, Sandra; Abete, Itziar; García‐Rios, Antonio; Ros, Emilio; Martínez‐González, Miguel Ángel

doi:10.1371/journal.pone.0198974

Cited by 125 publications

(125 citation statements)

References 36 publications

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“…It is worth noting that high consumption of vegetables is characteristic of the Mediterranean diet and although speculative, it is reasonable to assume that a higher vegetable intake may imply a higher adherence to the Mediterranean diet which has been associated extensively with HR-QoL [41–43]. Vegetables supply relatively high amounts of vitamins and minerals to the diet and are sources of phytochemicals that function as antioxidants, phytoestrogens, and anti-inflammatory agents with beneficial effects on general health and well-being [44–46].…”

Section: Discussionmentioning

confidence: 99%

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Higher vegetable intake and vegetable variety is associated with a better self-reported health-related quality of life (HR-QoL) in a cross-sectional survey of rural northern Ghanaian women in fertile age

2018

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BackgroundA higher vegetable intake plays an important role in promoting general health and well-being, but there is a dearth of data on the independent effect of vegetable intake on health-related quality of life (HR-QoL). This study contributes to evidence on the independent effect of vegetable consumption on HR-QoL among women in fertile age.MethodsA cross-sectional study of a sample of rural women in fertile age (15–49 years, n = 187), randomly selected from 6 rural communities in the Tolon and Savelugu Districts, Northern Region of Ghana. Vegetable consumption in the past month was assessed with a 27-item semi-quantitative food frequency questionnaire; self-reported HR-QoL with the Short Form Health Survey (SF-36); nutritional status with anthropometry; household food security with the household hunger scale (HHS) and demographic and socio-economic related covariates with a pre-tested semi-structured questionnaire using face-face interviews. Generalised Linear Models were fitted to assess adjusted mean scores and their 95% confidence intervals (95% CIs) by terciles of vegetable intake and vegetable variety score (VVS) for the HR-QoL, its physical health (PH) and mental health (MH) domains and the SF-36 subscales.ResultsThe mean vegetable intake of the women was 324.6 ± 196.1 g/day. The mean scores of the HR-QoL, PH and MH were 69.5 ± 13.6, 72.6 ± 17.4 and 66.4 ± 12.6 respectively. The alpha Cronbach measure of reliability for the HR-QoL, PH and MH were 0.78, 0.75 and 0.62 respectively. After adjusting for potential confounders such as age, body-mass-index (BMI), parity, educational status, occupation, marital status, HHS and household asset index, we observed an increasing trend across terciles of vegetable intake in the past month for the HR-QoL (P-trend = 0.0003), PH (P-trend = 0.02), MH (P-trend = 0.001) as well as the physical functioning (P-trend = 0.01), role-physical (P-trend <.0001), and role emotional (P-trend <.0001) domains of the SF-36. The multivariate model of the results also showed a significant increasing trend in the adjusted mean scores of the HR-QoL (P-trend = 0.04), MH (P-trend = 0.001) as well as 4 subscales of the SF-36 [role-physical (P-trend = 0.02), role-emotional (P-trend = 0.05), emotional well-being (P-trend = 0.002) and vitality (P-trend <.0001)] across terciles of the VVS.ConclusionThe results of the present study suggest a potential beneficial role of high vegetable intake and consumption of more varied vegetables on HR-QoL. Further research is needed to determine the mechanisms driving these influences.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-5845-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

“…Notably, physical activity is often adjusted for in many related studies [16, 42, 43], but the present study did not include an assessment of physical activity. Nonetheless, considering that the women were generally farmers engaged in labour-intensive agriculture, their physical activity was most likely high on the average.…”

Section: Discussionmentioning

confidence: 99%

Higher vegetable intake and vegetable variety is associated with a better self-reported health-related quality of life (HR-QoL) in a cross-sectional survey of rural northern Ghanaian women in fertile age

2018

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“…Notably, compared to a large number of studies examining the benefits of traditional diets such as the widely recommended Mediterranean diet [23,24], there are very few studies evaluating the health effects of the traditional Mexican diet [25][26][27]. Therefore, this study aimed first to evaluate the effects of a regionalized GENOMEX diet on biochemical and anthropometric parameters and, subsequently, their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD.…”

Section: Introductionmentioning

confidence: 99%

A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

et al. 2020

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Obesity-related chronic diseases (CD) are highly prevalent in Mexicans who show moderate to high frequencies of diet-related adaptive gene (DRAG) polymorphisms and recent shifts in traditional dietary habits and lifestyles. This study first evaluated the effects of a regionalized genome-based Mexican (GENOMEX) diet on anthropometric and biochemical parameters and, subsequently their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD. Thirty-seven eligible subjects underwent a 24-week dietary intervention with a GENOMEX diet. The DRAG polymorphisms were determined by an allelic discrimination real-time assay to evaluate their association with the clinical response to diet. The GENOMEX diet significantly improved anthropometric parameters such as total weight, body mass index, waist circumference, and body fat percentage, with an average weight loss of 6.6% (5.3 ± 5.3 kg). The frequency of subjects with insulin resistance, hypertriglyceridemia and elevated VLDL-c (48.5% vs. 24.2%, p = 0.041; 45.5% vs. 12.1%, p = 0.003; and 39.4% vs. 15.2%, p = 0.027, baseline vs. 24-weeks, respectively) was reduced. A more significant favorable effect in HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphism was associated with clinical changes. The GENOMEX diet improved the metabolic risk factors for obesity-related CD. The recommendation and habitual consumption of a traditional Mexican diet based on knowledge of the population's genetic and cultural history may be effective in preventing current obesity-related CD.Abstract: Obesity-related chronic diseases (CD) are highly prevalent in Mexicans who show moderate to high frequencies of diet-related adaptive gene (DRAG) polymorphisms and recent shifts in traditional dietary habits and lifestyles. This study first evaluated the effects of a regionalized genome-based Mexican (GENOMEX) diet on anthropometric and biochemical parameters and, subsequently their relationship with the genetic profile of DRAG polymorphisms in subjects with metabolic risk factors for obesity-related CD. Thirty-seven eligible subjects underwent a 24-week dietary intervention with a GENOMEX diet. The DRAG polymorphisms were determined by an allelic discrimination real-time assay to evaluate their association with the clinical response to diet. The GENOMEX diet significantly improved anthropometric parameters such as total weight, body mass index, waist circumference, and body fat percentage, with an average weight loss of 6.6% (5.3 ± 5.3 kg). The frequency of subjects with insulin resistance, hypertriglyceridemia and elevated VLDL-c (48.5% vs. 24.2%, p = 0.041; 45.5% vs. 12.1%, p = 0.003; and 39.4% vs. 15.2%, p = 0.027, baseline vs. 24-weeks, respectively) was reduced. A more significant favorable effect in HOMA-IR and insulin was observed in MTHFR 677T adaptive allele carriers, but no other DRAG polymorphism was associated with clinical changes. The GENOMEX diet improved the metabolic risk ...

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“…Considering quality of life, several studies in both healthy people and patients of all ages have underlined the positive association between higher diet quality and higher quality of life . Adherence to MD has also been associated with better quality of life both in adolescents and adults …”

Section: Introductionmentioning

confidence: 99%

Evaluating Mediterranean diet adherence in university student populations: Does this dietary pattern affect students' academic performance and mental health?

Antonopoulou

Mantzorou

Serdari

et al. 2019

Health Planning & Management

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Summary Adherence to a healthy diet such as Mediterranean Diet (MD) may exert beneficial effects in university students, promoting their academic performance and quality of life, as well as their mental and physical health status. In this aspect, the present study aimed to critically analyze the current epidemiological evidence concerning MD adherence of university students' populations. PubMed database was comprehensively searched, using relative keywords. Students' dietary habits are moving away from MD guidelines towards unhealthy eating patterns, especially for those living away from home and even for students with a Mediterranean country origin. Most of the available studies have documented that poorer students' health status was associated with lower MD adherence. Higher MD adherence was correlated with lower depression risk, while higher perceived stress score with lower fruit and vegetables intake. The access of students to information and knowledge provided by courses and lectures did not effectively enhance their compliance to MD. Alarmingly enough, the majority of students, even from medical and nutritional university departments, showed inadequate knowledge on healthy eating habits. Due to the influence of diet on the quality of life and the mental and physical health of students, it is crucial to redirect research focus on this important aspect.

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Mediterranean diet and quality of life: Baseline cross-sectional analysis of the PREDIMED-PLUS trial

Cited by 125 publications

References 36 publications

Higher vegetable intake and vegetable variety is associated with a better self-reported health-related quality of life (HR-QoL) in a cross-sectional survey of rural northern Ghanaian women in fertile age

Higher vegetable intake and vegetable variety is associated with a better self-reported health-related quality of life (HR-QoL) in a cross-sectional survey of rural northern Ghanaian women in fertile age

A Regionalized Genome-Based Mexican Diet Improves Anthropometric and Metabolic Parameters in Subjects at Risk for Obesity-Related Chronic Diseases

Evaluating Mediterranean diet adherence in university student populations: Does this dietary pattern affect students' academic performance and mental health?

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