Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial

Abstract

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Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. Eur J Heart Fail 2017;19:1179–1185. doi: 10.1002/ejhf.750

“…The corrected Table and Figure (see below; all corrections are marked in bold characters) show the corrected estimates for the outcome, as compared with those reported in the original paper. In consistency with the published paper, the unadjusted hazard ratios (HR) did not indicate significant associations for the MedDiet + EVOO [HR 0.63; 95% confidence interval (CI) 0.38–1.04] and MedDiet + nuts (HR 0.91; 95% CI 0.55–1.50), compared with the control group. Results from the multivariate analyses ( Table ) also remained unchanged.…”

“…Some departures from the individual randomization protocol affecting a small subset of participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial (at most 14%) have recently been reported in the re‐publication of the main PREDIMED paper . For this reason, the authors wish to make the following clarifications and corrections to their original PREDIMED sub‐study examining the effect of the Mediterranean diets (MedDiets), supplemented with extra‐virgin olive oil (EVOO) or nuts, on the risk of heart failure …”

The gut microbiota and its interactions with cardiovascular disease

“…Feeding mice with a high‐fibre diet increased the abundance of acetate‐producing gut bacteria, which significantly decreased myocardial hypertrophy and fibrosis (Marques, et al , ). Furthermore, a Mediterranean diet resulted in low TMAO levels, which can consequently prevent cardiovascular consequences and HF (Papadaki, et al , ; Estruch, et al , ). One study specifically demonstrated that ginger supplementation modulated the gut microbiota community, inducing a significant increase in fatty acid metabolism (Wang, et al , ).…”

September 2017 at a glance: epidemiology, prognosis, Mediterranean diet and different viewpoints on aspirin

“…The PREvención con DIeta MEDiterránea (PREDIMED) randomized controlled trial showed the beneficial effects of a Mediterranean diet supplemented with olive oil or nuts on major cardiovascular events . An analysis of HF events in this trial did not show a reduction in HF events . Such analysis was, however, likely underpowered because of the low incidence of these events.…”