Mediterranean diet for cancer prevention and survivorship

Monllor-Tormos, Aitana; García-Vigara, Alicia; Morgan, Orly; García-Pérez, Miguel-Ángel; Mendoza, Nicolás; Tarín, Juan J.; Cano, Antonio

doi:10.1016/j.maturitas.2023.107841

Cited by 13 publications

(4 citation statements)

References 75 publications

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“…The median time from initial ovarian cancer diagnosis to secondary cancer was 6.5 years, proving again the importance of survivorship care longer than the typical first five years [38]. These findings emphasize the importance of implementing lifestyle factors and prevention in the long-term follow-up care of cancer patients [39,40].…”

Section: Discussionmentioning

confidence: 77%

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey

Woopen,

Keller,

Zocholl

et al. 2023

Cancers

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The aim of this survey was to increase the knowledge on the characteristics and health concerns of long-term survivors (LTS; survival > 5 years) after ovarian cancer in order to tailor follow-up care. This international survey was initiated by the NOGGO and was made available to members of ENGOT and GCIG. The survey is anonymous and consists of 68 questions regarding sociodemographic, medical (cancer) history, health concerns including distress, long-term side effects, and lifestyle. For this analysis, 1044 LTS from 14 countries were recruited. In total, 58% were diagnosed with FIGO stage III/IV ovarian cancer and 43.4% developed recurrent disease, while 26.0% were receiving cancer treatment at the time of filling in the survey. LTS who survived 5–10 years self-estimated their health status as being significantly worse than LTS who survived more than 10 years (p = 0.034), whereas distress also remained high 10 years after cancer diagnosis. Almost half of the cohort (46.1%) reported still having symptoms, which were mainly lymphedema (37.7%), fatigue (23.9%), pain (21.6%), polyneuropathy (16.9%), gastrointestinal problems (16.6%), and memory problems (15.5%). Almost all patients (94.2%) regularly received follow-up care. Specialized survivorship care with a focus on long-term side effects, lifestyle, and prevention should be offered beyond the typical five years of follow-up care.

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Section: Discussionmentioning

confidence: 77%

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey

Woopen,

Keller,

Zocholl

et al. 2023

Cancers

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“…A recent narrative review on MedDiet for cancer prevention has concluded to an inverse relationship, or at least a neutral association, between the diet and risk of most types of cancer, with the limitation that mostly observational studies were analysed [ 51 ]. A meta-analysis including 117 studies with 3,202,496 participants has demonstrated a reduction of 13% for cancer mortality (18 studies), of 25% for all-cause mortality among cancer survivors (8 studies), of 6% for breast (23 studies), of 17% for colo-rectal (17 studies), of 44% for head and neck (9 studies), of 16% for respiratory (5 studies), of 30% for gastric (7 studies), 13% for bladder (4 studies), and of 36% for liver cancers (4 studies) [ 52 ].…”

Section: Cancer Riskmentioning

confidence: 99%

Role of fermented dairy products in the health benefits of a mediterranean diet

Rizzoli,

Biver

2024

Aging Clin Exp Res

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Mediterranean diet includes fermented dairy products like yogurt and cheese. These foods provide calcium, phosphorus, fat, carbohydrates and protein, all nutrients influencing various systems including bone, cardiovascular system, intermediary metabolism, cancer, central nervous system, and inflammation. In addition, they contain prebiotics and provide probiotics which are capable of modifiying microbiota composition and metabolism, potentially acting also indirectly on the various systems. A large body of evidence indicates that fermented dairy products consumption significantly contributes to the beneficial effects of a Mediterranean diet on various systems’ health.

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“…This further emphasizes the need for caution when interpreting the results of nutrition studies since perfectly controlling diet over the long term is inherently challenging. The consensus among experts currently advocates for a balanced diet, exemplified by the Mediterranean Diet, which protects against cardiovascular issues and supports cancer prevention (42) (43). These evolving recommendations underscore the statistical advantages of employing concrete endpoints, such as diagnosed cardiovascular events, instead of surrogate endpoints.…”

Section: Saturated Fats and Heart Diseasementioning

confidence: 99%

Statistics, Ethics, and the Promotion of Reproducible Research

Heston

2023

Preprint

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Rigorous statistical methodology represents a vital framework for upholding research integrity and maximizing benefits in medical science. However, the misuse of statistical tools contradicts ethical tenets and compromises validity. Problematic trends like p-hacking, hyping delicate results, and overemphasizing statistical significance relative to clinical meaning introduce prejudice and impede reproducibility. Case studies, including hormone replacement therapy trials, exhibit how unsound statistics propagate doubtful conclusions and potential injury. Resolving the ”reproducibility crisis” necessitates proper statistical techniques such as sufficient power, preregistration, transparent data, and Bayesian approaches. Statistics and ethics are profoundly intertwined in accountable medical inquiry. By prioritizing statistical meticulousness, investigators can satisfy their ethical duty to generate reproducible discoveries that aid patients and society. Proper statistical application is indispensable for advancing medically and socially impactful research.

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Mediterranean diet for cancer prevention and survivorship

Cited by 13 publications

References 75 publications

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey

Role of fermented dairy products in the health benefits of a mediterranean diet

Statistics, Ethics, and the Promotion of Reproducible Research

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