Mediterranean diet–gene interactions: A targeted metabolomics study in Greek‐Cypriot women

Kakkoura, Maria G.; Sokratous, Kleitos; Demetriou, Christiana A.; Loizidou, Maria A.; Loucaides, Giorgos; Kakouri, Eleni; Hadjisavvas, Andreas; Kyriacou, Kyriacos

doi:10.1002/mnfr.201600558

Cited by 20 publications

(21 citation statements)

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“…Since the whole body participates in the metabolic process and each cell releases its own metabolites, many factors can influence the results of metabolomics raw data29 such as, gender,30 drug usage3 and dietary habits.31 African-American or Caucasian women have shown different metabolic profiles of triple-negative breast cancer (TNBC) 32. These differences suggest that racial differences may alter the metabolites of BC.…”

Section: Factors Influencing Metabolomics Raw Datamentioning

confidence: 99%

<p>Metabolomics: a promising diagnostic and therapeutic implement for breast cancer</p>

Chen¹,

Li²,

Li³

et al. 2019

OTT

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Breast cancer (BC) is the most commonly diagnosed cancer among women and the leading cause of cancer death. Despite the advent of numerous diagnosis and treatment methods in recent years, this heterogeneous disease still presents great challenges in early diagnosis, curative treatments and prognosis monitoring. Thus, finding promising early diagnostic biomarkers and therapeutic targets and approaches is meaningful. Metabolomics, which focuses on the analysis of metabolites that change during metabolism, can reveal even a subtle abnormal change in an individual. In recent decades, the exploration of cancer-related metabolomics has increased. Metabolites can be promising biomarkers for the screening, response evaluation and prognosis of BC. In this review, we summarized the workflow of metabolomics, described metabolite signatures based on molecular subtype as well as reclassification and then discussed the application of metabolomics in the early diagnosis, monitoring and prognosis of BC to offer new insights for clinicians in breast cancer diagnosis and treatment.

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Section: Factors Influencing Metabolomics Raw Datamentioning

confidence: 99%

<p>Metabolomics: a promising diagnostic and therapeutic implement for breast cancer</p>

Chen¹,

Li²,

Li³

et al. 2019

OTT

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“…That has motivated lots of studies focusing on the potential link between the nutrients associated with onecarbon metabolism pathway and carcinogenesis (Milne, et al 2017, Weinstein, et al 2006. A previous study showed that SNPs of one-carbon metabolism gene have interactions with folate intake to affect the BC risk (Kakkoura, et al 2017). However, most previous studies focus on the effect of individual nutrients rather than a combination of foods (Lissowska, et al 2007), which have been limited in interpreting the high degree of intercorrelation among various nutrients.…”

Section: Discussionmentioning

confidence: 99%

Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and the risk of pre- and postmenopausal breast cancer

Cao¹,

Zhu

Zhou

et al. 2020

Preprint

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Background: One-carbon metabolism pathway could interfere with the carcinogenesis of breast cancer (BC). Dietary pattern plays an important role in one-carbon metabolism linking the combination of dietary micronutrients. Methods: We assessed associations between single-nucleotide polymorphisms (SNPs) of one-carbon metabolism, adherence to Mediterranean dietary pattern (MDP) and BC risk from a case-control study (818 cases, 935 controls) among Chinese female population. The genotyping of 10 SNPs in seven one-carbon metabolism-related genes (MTHFD1, MTRR, MAT2B, CDO1, FOLR1, UNG2, ADA) were performed. Dietary intake measurements were assessed by a validated food-frequency questionnaire. Gene-diet interactions were analyzed. Results: No evidence demonstrated SNPs of one-carbon metabolism or their haplotypes were associated with BC risk. High adherence to the Mediterranean dietary pattern decreased the risk of breast cancer among post- but not premenopausal women and the association was influenced by the SNPs genotype, with the increasing number of variant allele in MTHFD1 (rs11627387), MTHFD1 (rs2281603), MTRR (rs16879334), MTRR (rs2287780), MAT2B (rs4869087), FOLR1 (rs10501409), UNG2 (rs231622) and ADA (rs244072). The protective effect against BC risk from high adherence to the MDP was gradually weakened and disappeared. For MTHFD1 (rs8003567) and CDO1 (rs34869) genotypes, women with homozygous were less affected by adherence to the MDP than to women who with heterozygotes. No significant gene-diet interactions were observed.Conclusions: SNPs of one-carbon metabolism genes modify the effect of high adherence to MDP against BC risk in Chinese women, as potential effect modifiers. Genetic variants may influence the association between diet and BC risk.

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“…This has motivated lots of studies focusing on the potential associations between the nutrients associated with one-carbon metabolism pathway and carcinogenesis (Milne, et al 2017, Weinstein, et al 2006. As previous studies showed, some SNPs of one-carbon metabolism gene have interactions with folate intake to affect the BC risk (Kakkoura, et al 2017). However, the majority of the previous studies focus on the effect of individual nutrients rather than a combination of foods (Lissowska, et al 2007), which have been limited in interpreting the high degree of intercorrelation among various nutrients.…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleotide Polymorphisms in One-Carbon Metabolism Genes, Mediterranean Diet and the Risk of Pre- and Postmenopausal Breast Cancer

Cao¹,

Zhu

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: One-carbon metabolism pathway could interfere with the carcinogenesis of breast cancer (BC). Dietary pattern plays an important role in one-carbon metabolism linking the combination of dietary micronutrients. Methods: We assessed associations between single-nucleotide polymorphisms (SNPs) of one-carbon metabolism, adherence to Mediterranean dietary pattern (MDP) and BC risk from a case-control study (818 cases, 935 controls) among Chinese female population. The genotyping of 15 SNPs in eleven one-carbon metabolism-related genes (MTHFD1, MTRR, MAT1A, MAT2B, FOLR1, CBS, GLS, DNMT3B, UNG2, ADA, CDO1) were performed. Dietary measurements were assessed by a validated food-frequency questionnaire. Gene-diet interactions were analyzed. Results: No evidence demonstrated SNPs of one-carbon metabolism or their haplotypes were associated with BC risk. The associations between high adherence to the MDP and risk reduction of BC were influenced by the SNPs genotype, with the increasing number of variant allele in MTHFD1 (rs11627387), MTHFD1 (rs2281603), MTRR (rs16879334), MTRR (rs2287780), MAT2B (rs4869087), FOLR1 (rs10501409), UNG2 (rs231622) and ADA (rs244072), the protective effect against BC risk from high adherence to the MDP was gradually weakened and disappeared, while for MTHFD1 (rs8003567) and CDO1 (rs34869) genotypes, women who take homozygous allele were less affected by adherence to the MDP than to women who take heterozygotes allele. Significant gene-diet interactions were observed between MTHFD1 (rs8003567) polymorphism and MDP on BC risk. Conclusions: SNPs of one-carbon metabolism genes modify the effect of high adherence to MDP against BC risk in Chinese women, as potential effect modifiers. Genetic variants may influence the association between diet and BC risk.

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Mediterranean diet–gene interactions: A targeted metabolomics study in Greek‐Cypriot women

Abstract: Serum levels of flavin mononucleotide and 5-MTHF were shown to be influenced by interactions between GSTM1 deletion or MTHFR (rs1801133) polymorphisms and a dietary pattern, characteristic of MD.

Cited by 20 publications

References 60 publications

<p>Metabolomics: a promising diagnostic and therapeutic implement for breast cancer</p>

<p>Metabolomics: a promising diagnostic and therapeutic implement for breast cancer</p>

Single-nucleotide polymorphisms in one-carbon metabolism genes, Mediterranean diet and the risk of pre- and postmenopausal breast cancer

Single-Nucleotide Polymorphisms in One-Carbon Metabolism Genes, Mediterranean Diet and the Risk of Pre- and Postmenopausal Breast Cancer

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