Mediterranean diet improves embryo yield in IVF: a prospective cohort study

Sun, Haixiang; Lin, Yihua; Lin, Dan; Chang-e, Zou; Zou, Xiangli; Fu, Lan; Meng, Fanqi; Qian, Weiping

doi:10.1186/s12958-019-0520-9

Cited by 45 publications

(71 citation statements)

References 28 publications

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“… + Indicates dietary component is used to calculate the total dietary score and contributes to a higher score - indicates dietary component is used to calculate the total dietary score and contributes to a lower score a Sun 2019 [ 52 ] did not include alcohol b Sun 2019 [ 52 ] and Vujkovic 2010 [ 54 ] did not include potatoes c Gaskins 2019 [ 48 ], Karayiannis 2018 [ 49 ] and Sun 2019 [ 52 ] specified unrefined or whole grain; Vujkovic 2010 [ 54 ] did not include cereal d Sun 2019 [ 52 ] included nuts e Gaskins 2019 [ 48 ] and Karayiannis 2018 [ 49 ] specified full fat dairy; Vujkovic 2010 [ 54 ] did not include dairy f Vujkovic 2010 [ 54 ] did not included meat, Gaskins 2019 [ 48 ] specified red meat g Ricci 2019 [ 50 ], Sun 2019 [ 52 ], and Vujkovic 2010 [ 54 ] did not include or specify poultry h high fat dairy contributed positively, and low-fat dairy contributed negatively I low pesticide fruits and vegetables contributed positively, and high pesticide fruits and vegetables contributed negatively low pesticide fruits and vegetables contributed positively and high pesticide fruits and vegetables contributed negatively j only whole grain cereal k Vujkovic 2010 [ 54 ] did not include fruits l Vujkovic 2010 [ 54 ] specified vegetable oil, Ricci 2019 [ 50 ] high monounsaturated/saturate fatty acid ratio, Gaskins 2019 [ 48 ] and Karayiannis 2018 [ 49 ] specified olive oil m Sugawa 2018 [ 51 ] specified red meat n Sugawa 2018 [ 51 ] specified oils …”

Section: Resultsmentioning

confidence: 99%

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Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review

Sanderman

Willis

Wise

2022

Nutr J

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Background Infertility affects up to 15% of couples. In vitro fertilization (IVF) treatment has modest success rates and some factors associated with infertility and poor treatment outcomes are not modifiable. Several studies have assessed the association between female dietary patterns, a modifiable factor, and IVF outcomes with conflicting results. We performed a systematic literature review to identify female dietary patterns associated with IVF outcomes, evaluate the body of evidence for potential sources of heterogeneity and methodological challenges, and offer suggestions to minimize heterogeneity and bias in future studies. Methods We performed systematic literature searches in EMBASE, PubMed, CINAHL, and Cochrane Central Register of Controlled Trials for studies with a publication date up to March 2020. We excluded studies limited to women who were overweight or diagnosed with PCOS. We included studies that evaluated the outcome of pregnancy or live birth. We conducted an initial bias assessment using the SIGN 50 Methodology Checklist 3. Results We reviewed 3280 titles and/or titles and abstracts. Seven prospective cohort studies investigating nine dietary patterns fit the inclusion criteria. Higher adherence to the Mediterranean diet, a ‘profertility’ diet, or a Dutch ‘preconception’ diet was associated with pregnancy or live birth after IVF treatment in at least one study. However, causation cannot be assumed. Studies were potentially hindered by methodological challenges (misclassification of the exposure, left truncation, and lack of comprehensive control for confounding) with an associated risk of bias. Studies of the Mediterranean diet were highly heterogenous in findings, study population, and methods. Remaining dietary patterns have only been examined in single and relatively small studies. Conclusions Future studies with rigorous and more uniform methodologies are needed to assess the association between female dietary patterns and IVF outcomes. At the clinical level, findings from this review do not support recommending any single dietary pattern for the purpose of improving pregnancy or live birth rates in women undergoing IVF treatment.

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Section: Resultsmentioning

confidence: 99%

“…c Gaskins 2019 [ 48 ], Karayiannis 2018 [ 49 ] and Sun 2019 [ 52 ] specified unrefined or whole grain; Vujkovic 2010 [ 54 ] did not include cereal…”

Section: Resultsmentioning

confidence: 99%

Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review

Sanderman

Willis

Wise

2022

Nutr J

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“…In a study of 590 women undergoing in vitro fertilization (IVF), those with greater MD adherence had a greater yield of fertilized oocytes and embryos. 105 In a Greek study, compared with women in the highest tertile of MD adherence, women in the lowest tertile had significantly lower rates of clinical pregnancy (29.1% vs 50.0%; P = .01) and live birth (26.6% vs 48.8%; P = .01). Among women <35 years old, increased MD score was associated with an ~2.7 times higher likelihood of achieving clinical pregnancy and live birth.…”

Section: Fertilitymentioning

confidence: 94%

Dietary Approaches to Women’s Sexual and Reproductive Health

Kudesia

Alexander

Gulati³

et al. 2021

American Journal of Lifestyle Medicine

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Over the course of the reproductive life span, it is common for women to experience one or more of the most common gynecologic conditions, including sexual dysfunction, polycystic ovary syndrome, fibroids, endometriosis, and infertility. Although current management guidelines often turn to the established pharmaceutical approaches for each of these diagnoses, the scientific literature also supports an evidence-based approach rooted in the paradigm of food as medicine. Achieving healthy dietary patterns is a core goal of lifestyle medicine, and a plant-forward approach akin to the Mediterranean diet holds great promise for improving many chronic gynecologic diseases. Furthermore, creating an optimal preconception environment from a nutritional standpoint may facilitate epigenetic signaling, thus improving the health of future generations. This state-of-the-art review explores the literature connecting diet with sexual and reproductive health in premenopausal women.

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“…In the sub-fertile population, diet has been related to fertility [ 177 , 178 ] and implicated in the intermediate ART outcomes, such as fertilization rate [ 179 ] and embryo yield [ 180 ], as well as clinical outcomes, including, importantly, pregnancy [ 181 ] and live birth rates [ 179 ]. Adherence to a healthy dietary pattern increased the number of mature oocytes [ 181 , 182 ].…”

Section: Diet and Art Outcomesmentioning

confidence: 99%

“…Higher fertility and implantation rates were associated with the Iranian traditional medicine (ITM)-based diet and “pro-fertility” diet, respectively [ 181 , 183 ]. Increased embryo yield was observed with higher adherence towards the Mediterranean and ITM-based diets [ 180 , 181 ]. The chance of pregnancy was also improved with increased adherence to the “pro-fertility”, Mediterranean and ITM-based diets [ 181 , 183 , 184 , 185 ].…”

Section: Diet and Art Outcomesmentioning

confidence: 99%

Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences

Peral-Sanchez

Hojeij

Ojeda

et al. 2021

Genes

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The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutritional status can affect embryonic development. This review summarises the main epigenetic modifications in mammals, especially DNA methylation, histone modifications, and ncRNA. These epigenetic changes can compromise the health of the offspring later in life. We discuss different types of nutritional stressors in human and animal models, such as maternal undernutrition, seasonal diets, low-protein diet, high-fat diet, and synthetic folic acid supplement use, and how these nutritional exposures epigenetically affect target genes and their outcomes. In addition, we review the concept of thrifty genes during the preimplantation period, and some examples that relate to epigenetic change and diet. Finally, we discuss different examples of maternal diets, their effect on outcomes, and their relationship with assisted reproductive technology (ART), including their implications on epigenetic modifications.

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Mediterranean diet improves embryo yield in IVF: a prospective cohort study

Cited by 45 publications

References 28 publications

Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review

Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review

Dietary Approaches to Women’s Sexual and Reproductive Health

Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences

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