Mediterranean Diet Score and Its Association with Age-Related Macular Degeneration

Hogg, Ruth; Woodside, Jayne V.; McGrath, A. J.; Young, Ian S.; Vioque, Jesús; Chakravarthy, Usha; Jong, P.T. de; Rahu, Mati; Seland, Johan H.; Soubrane, G.; Tomazzoli, Laura; Topouzis, Fotis; Fletcher, Astrid

doi:10.1016/j.ophtha.2016.09.019

Cited by 69 publications

(76 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early AMD, which is largely asymptomatic, is estimated to affect ≈150 million individuals globally, whilst the late‐stage sight threatening nv/GA forms causes blindness in approximately 10 million patients worldwide . An unhealthy diet contributes to the risk of developing AMD in the same way that a healthier “Mediterranean” diet or an increased intake of fish and nuts appear to confer protection . Therefore, based on initial findings from the Age‐related Eye Disease Study (AREDS) some patients are prescribed antioxidants and zinc supplements .…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

Keeling

Chatelet

Johnston

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Oxidative stress and dysregulated intracellular trafficking are associated with an unhealthy diet which underlies pathology. Here, these effects on photoreceptor outer segment (POS) trafficking in the retinal pigment epithelium (RPE), a major pathway of disease underlying irreversible sight‐loss, are studied. Methods and results POS trafficking is studied in ARPE‐19 cells using an algorithm‐based quantification of confocal‐immunofluorescence data supported by ultrastructural studies. It is shown that although POS are tightly regulated and trafficked via Rab5, Rab7 vesicles, LAMP1/2 lysosomes and LC3b‐autophagosomes, there is also a considerable degree of variation and flexibility in this process. Treatment with H2O2 and bafilomycin A1 reveals that oxidative stress and dysregulated autophagy target intracellular compartments and trafficking in strikingly different ways. These effects appear limited to POS‐containing vesicles, suggesting a cargo‐specific effect. Conclusion The findings offer insights into how RPE cells cope with stress, and how mechanisms influencing POS transport/degradation can have different outcomes in the senescent retina. These shed new light on cellular processes underlying retinopathies such as age‐related macular degeneration. The discoveries reveal how diet and nutrition can cause fundamental alterations at a cellular level, thus contributing to a better understanding of the diet‐disease axis.

show abstract

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

Keeling

Chatelet

Johnston

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly population in developed countries [1, 2]. There are 2 types of the disease, dry and wet type [3].…”

Section: Introductionmentioning

confidence: 99%

Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model

et al. 2017

View full text Add to dashboard Cite

BackgroundSeveral studies associated high-fat intakes with a high incidence of age-related macular degeneration (AMD). Lutein and Zeaxanthin isomers (L/Zi) may counteract reactive oxygen species produced by oxidative stress. The present study was conducted to determine the possible effects of L/Zi administration on lipid profile, protein genes associated with oxidative stress and inflammation pathways in the obesity induced by a high-fat diet (HFD) in rodents.MethodsTwenty-eight male Wistar rats were allocated into four groups as follows: (i) Control, (ii) Control + L/Zi, (iii) High Fat Diet (HFD), and (iv) HFD+ L/Z. L/Zi was administrated for 8 weeks at a daily dose of 100 mg/kg BW.ResultsL/Zi administration significantly reduced insulin and free fatty acid (FFA) levels (P < 0.001) and ameliorated the oxidative damage by reducing malondialdehyde (MDA) concentration and increasing antioxidant enzymes activities of retina induced by HFD. In addition, supplementation decreased the levels of vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM) (P < 0.001, respectively) and improved nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues (P < 0.001).ConclusionRats fed with HFD exhibited increased oxidative stress and upregulation of inflammatory indicators. However, L/Zi supplementation modulates genes involved oxidative stress and inflammation including NF-κB and Nrf2 signaling pathways in the retina which may contribute to ameliorating retinal damage induced by HFD.

show abstract

“…When considering high adherence to the diet (mediSCORE ≥6), a protective effect was apparent in our sample, which is comprised mostly of early AMD cases. A similar study by Hogg and colleagues documented a protective effect of the Mediterranean diet for late, but not early AMD (Hogg et al 2016). A similar study by Hogg and colleagues documented a protective effect of the Mediterranean diet for late, but not early AMD (Hogg et al 2016).…”

Section: The Mediterranean Diet and Food Consumption Habitsmentioning

confidence: 73%

“…There is some evidence that adherence to a Mediterranean diet may be associated with a decreased risk for AMD (Mares et al 2011;Merle et al 2015). Recently, a similar study in the EUROEYE cohort, including centres from Southern to Northern Europe, was recently conducted, showing a protective effect for late, but not early, AMD (Hogg et al 2016). Recently, a similar study in the EUROEYE cohort, including centres from Southern to Northern Europe, was recently conducted, showing a protective effect for late, but not early, AMD (Hogg et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Adherence to a Mediterranean diet, lifestyle and age‐related macular degeneration: the Coimbra Eye Study – report 3

Raimundo

Mira

Cachulo

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

Mediterranean Diet Score and Its Association with Age-Related Macular Degeneration

Cited by 69 publications

References 37 publications

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)

Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model

Adherence to a Mediterranean diet, lifestyle and age‐related macular degeneration: the Coimbra Eye Study – report 3

Contact Info

Product

Resources

About