Mediterranean spotted fever in Salamanca, Spain. Epidemiological study in patients and serosurvey in animals and healthy human population

Herrero‐Herrero, J. I.; Ruiz-Beltrán, R.; Martı́n-Sánchez, Antonio Manuel; García, Enrique

doi:10.1016/0001-706x(89)90046-6

Cited by 32 publications

(29 citation statements)

References 16 publications

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“…Dogs serve as common transport hosts by bringing infected ticks closer to their owners. In certain zones of southern Europe, a correlation between the percentage of the canine population with antibodies to R. conorii conorii and the incidence of MSF in humans has been found (37). Seropositivity was even higher in dogs belonging to MSF patients (37).…”

Section: What Is the Real Reservoir Of R Conorii Conorii?mentioning

confidence: 99%

“…In certain zones of southern Europe, a correlation between the percentage of the canine population with antibodies to R. conorii conorii and the incidence of MSF in humans has been found (37). Seropositivity was even higher in dogs belonging to MSF patients (37). Dogs are transient reservoirs because of transient rickettsemia after infection; therefore, dogs do not seem to be an effi cient reservoir for R. conorii conorii.…”

Section: What Is the Real Reservoir Of R Conorii Conorii?mentioning

confidence: 99%

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Questions on Mediterranean Spotted Fever a Century after Its Discovery

Rovery

Brouqui²,

Raoult³

2008

Emerg. Infect. Dis.

136

110

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Section: What Is the Real Reservoir Of R Conorii Conorii?mentioning

confidence: 99%

Section: What Is the Real Reservoir Of R Conorii Conorii?mentioning

confidence: 99%

Questions on Mediterranean Spotted Fever a Century after Its Discovery

Rovery

Brouqui²,

Raoult³

2008

Emerg. Infect. Dis.

136

110

View full text Add to dashboard Cite

show abstract

“…Tick rickettsia of the spotted fever group are transmitted vertically and transovarially, and immature stages are as frequently infected as are adults. This hypothesis has been confirmed by Herrero et al (17), who has just published a paper reporting that 7 nymphs of R. sanguineus were observed on the "tache noire" of patients in Spain.…”

Section: Discussionmentioning

confidence: 56%

“…vectors. These ticks have been observed in France (21), in Spain (11,17), and in Italy (10,29). Each of these species has been linked to infections caused by Rickettsiae of the spotted fever group (14 …”

Section: Mediterraneanmentioning

confidence: 94%

Relationships between the Rhipicephalus sanguineus complex ecology and mediterranean spotted fever epidemiology in France

et al. 1990

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The authors examine the epidemiologic features of Mediterranean spotted fever in France in light of the bioecological peculiarities of each of the three known member of the Rhipicephalus sanguineus tick group (R. sanguineus, R. turanicus, R. pusillus). The results show that R. sanguineus is the main vector. Certain aspects of this tick species are of interest: affinity for man, close contact with humans for a long periods, peak of tick population (preimaginal stages) at the same time as the peak of the disease. The largest populations of R. sanguineus are noted in the endemic zone of human rickettsiosis. The fact that immature stages are more prevalent during the hot season and these forms' ability to bite humans is important and may suggest a role for them in the epidemiology of the disease. The sporadic isolation of this species outside the endemic zone may explain the occurrence of isolated cases of the disease in these areas. We cannot currently exclude vector roles for the two other species, which can parasitize humans, though none of our data supports this hypothesis.

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“…8,[12][13][14] The cut-off value of 1:64 for positive IgM IFA and IgG IFA test results is within the range 1: 32-1:128 found elsewhere in the literature. 3,7,[15][16][17][18][19] By changing the cut-off value, there would have been different criteria for positive and negative results, and, therefore, different summary statistics.…”

Section: Discussionmentioning

confidence: 99%

Laboratory evaluation of a dot-blot enzyme immunoassay for serologic confirmation of illness due to Rickettsia conorii.

Broadhurst¹,

Kelly²,

Chan³

et al. 1998

The American Journal of Tropical Medicine and Hygiene

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Abstract. Of the 169 United States Army soldiers who deployed on a field training exercise to a remote area of Botswana for two weeks in January 1992, more than 30% developed a febrile illness within five days of their return. A diagnosis of South African tick typhus was suggested by soldiers' exposure to ticks, as well as the presence of eschars and vesicles at the site of tick bites, and tender regional lymphadenopathies. This high attack rate, experienced during such a short exposure period, emphasizes the hazard of illness due to Rickettsia conorii to persons visiting endemic areas. A rapid, diagnostic, semiquantitative enzyme immunoassay (DS) for detection of IgG and IgM antibodies to R. conorii was performed on 209 acute and convalescent sera from soldiers in the outbreak and on 75 control sera. For the acute sera from soldiers meeting the probable case definition of having both regional lymphadenopathy and tick bite eschar, as judged by an IgG indirect fluorescent antibody (IFA) test, the resulting sensitivity and specificity of the DS test were 100% and 48%, respectively. In the analysis of the acute sera, the DS test identified as reactive more of the probable cases (62%) than either the IgG (16%) or IgM (55%) IFAs. This simple and rapid diagnostic test could be useful in establishing a preliminary diagnosis of R. conorii rickettsiosis in remote settings when immediate confirmation by IFA is impossible.

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Mediterranean spotted fever in Salamanca, Spain. Epidemiological study in patients and serosurvey in animals and healthy human population

Cited by 32 publications

References 16 publications

Questions on Mediterranean Spotted Fever a Century after Its Discovery

Questions on Mediterranean Spotted Fever a Century after Its Discovery

Relationships between the Rhipicephalus sanguineus complex ecology and mediterranean spotted fever epidemiology in France

Laboratory evaluation of a dot-blot enzyme immunoassay for serologic confirmation of illness due to Rickettsia conorii.

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