Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability

Abstract

This is the first evidence of tomato-based sofrito protection against vascular alterations that could precede major cardiometabolic complications in obesity. These results contribute to explain the therapeutic properties of the Mediterranean diet in obesity-related disorders. Therefore, sofrito is an attractive dietary approach against vascular alterations in obesity.

Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats

“…Taking into account sofrito ’s rich bioactive compound content, here we analyzed the impact of a regular consumption of sofrito on insulin sensitivity in an obese rat model and identified FGF21 signaling as a mechanism by which sofrito could exert, at least in part, its healthy effects. This work is closely related to a previous one where the authors described that sofrito protects against vascular alterations that could precede major cardiometabolic complications in obesity …”

“…Obesity is usually associated with insulin resistance and glucose intolerance. OZR showed increased levels of blood glucose and those values are not significantly changed by a CD supplemented with sofrito . To test the effect of sofrito on insulin sensitivity we performed an ITT with the different experimental groups.…”

“…This work is closely related to a previous one where the authors described that sofrito protects against vascular alterations that could precede major cardiometabolic complications in obesity. [42]…”

Mediterranean sofrito home‐cooking technique enhances polyphenol content in tomato sauce

“…Epidemiological studies have shown that the consumption of processed tomato‐based products has a greater correlation with a low incidence of chronic‐degenerative diseases compared to raw tomato . Moreover, tomato sofrito consumption is associated with improved cardiovascular risk parameters and insulin sensitivity, and activates thermogenesis by browning fat tissue . This key component of the Mediterranean diet has also recently been correlated with the manifestation of less aggressive prostate cancer …”

“…10 Moreover, tomato sofrito consumption is associated with improved cardiovascular risk parameters and insulin sensitivity, and activates thermogenesis by browning fat tissue. 11,12 This key component of the Mediterranean diet has also recently been correlated with the manifestation of less aggressive prostate cancer. 13 The aim of this study was to evaluate how the sofrito cooking technique and ingredients used to prepare tomato sofrito sauce could improve the content of tomato phenolic compounds.…”