Medium-dose 308-nm excimer laser for the treatment of psoriasis

Trehan, Manju; Taylor, Charles R.

doi:10.1067/mjd.2002.125075

Cited by 78 publications

(70 citation statements)

References 16 publications

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“…Two independent studies reported that during treatment with the 308 nm excimer UVB laser, approximately 40% of patients developed blisters, some needing 7-14 days until complete healing. 14,20 In the current study, we have demonstrated that the use of LED technology results in similar clinical outcome as that of the 308 nm laser, 21 and has a better side-effect profile. Eight weeks of targeted phototherapy using UVB-LEDs resulted in similar decreases in PSI scores and improvement rates as targeted delivery with the BClear system (a UVB lamp which has the peak emission of 305-313 nm).…”

Section: Discussionmentioning

confidence: 70%

“…Mineral oil has been frequently used in targeted phototherapy as it does not absorb radiation, and by decreasing the reflectance it increases the therapeutic effect of UV radiation. 21,25 The disadvantage of both the 308 nm laser and the BClear system is that they are limited to outpatient use. A fundamental requirement of successful phototherapy is application of several treatments over a short time period, resulting in frequent clinic visits which leads to low compliance.…”

mentioning

confidence: 99%

“…21,22 Future development of the device, such as adding the capability of the physician to preprogram the treatment regimen, will fulfil the physician's requirement to be able to control and track the patient's phototherapy at home and would ultimately result in a decrease of uncontrolled self-administered treatments. Therefore UVB-LEDs may represent an attractive alternative therapy for mild and moderate psoriasis.…”

mentioning

confidence: 99%

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Targeted phototherapy of plaque-type psoriasis using ultraviolet B-light-emitting diodes

Kemény

Csoma

Bagdi³

et al. 2010

British Journal of Dermatology

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Summary Background One of the major technological breakthroughs in the last decade is represented by the diversified medical applications of light‐emitting diodes (LEDs). LEDs emitting in the ultraviolet (UV) B spectrum might serve as a more convenient alternative for targeted delivery of phototherapy in inflammatory skin diseases such as psoriasis. Objectives We investigated the efficacy and safety of a new UVB‐LED phototherapeutic device in chronic plaque‐type psoriasis. Methods Twenty patients with stable plaque‐type psoriasis were enrolled into a prospective, right‐left comparative, open study. Symmetrical lesions located on extremities or trunk were chosen; one lesion was treated with the study device, whereas the other lesion served as an untreated control. Two treatment regimens were used in the study, one with an aggressive dose escalation similar to those used for outpatient treatment and one with slow increase in dose, similar to those used for treatment at home. Results Patients in both groups responded rapidly to the UVB‐LED therapy. Early disease resolution was observed in 11 patients (seven in the first group and four in the second group). Overall improvement at end of therapy was 93% in the high‐dose group and 84% in the low‐dose group. Four patients from the high‐dose group and five from the low‐dose group were still in remission at the 6‐month follow‐up visit. Conclusions These results suggest that this innovative UVB‐LED device is effective in the treatment of localized psoriasis and may be useful in other UV‐responsive skin diseases.

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Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Targeted phototherapy of plaque-type psoriasis using ultraviolet B-light-emitting diodes

Kemény

Csoma

Bagdi³

et al. 2010

British Journal of Dermatology

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“…Für diese Modalität wurden Studien mit Behandlungsfrequenzen von zwei [181], drei [182][183][184][185][186], fünf [187,188] [191], zweimal [192][193][194], dreimal [147,184,195,196] oder 4 x/Wo [193,197] In mehreren kleinen [195,[199][200][201] sowie einer größeren nichtrandomisierten Studie [202] [197,212] treten jedoch mit ca. 5 % eher selten auf [197].…”

Section: Uv-b (Breitspektrum)unclassified

S3‐Leitlinie zur Therapie der Psoriasis vulgaris Update 2011

Nast¹,

Boehncke²,

Mrowietz³

et al. 2011

J Deutsche Derma Gesell

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“…The second, which includes agent-based models that involve keratinocytes under certain biological and physical rules. Both models simulate the multi-layers of the skin regulated by cell differentiation, proliferation, migration, and death in which certain biochemical factors change the behaviors of the epidermal structure [25]. There has been research performed by mathematicians jointly with biologists to investigate the psoriasis pathogenesis dynamics and treatments effects.…”

Section: Introductionmentioning

confidence: 99%

Optimal Treatment Strategies for Control Model of Psoriasis

Grigorieva¹,

Хайлов²,

Deignan³

2017

2017 Proceedings of the Conference on Control and Its Applications

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Psoriasis is an autoimmune disorder with the symptom of chronic inflammation of the skin. Psoriasis makes skin cells build up quickly on the skin surface which causes the skin to appear red, dry, and with scaly patches. Adequate treatment for psoriasis is very challenging and a total cure of the disease still does not exit. Mathematical models have long been effective means to predict cellular behaviors of skin regulation under normal or pathological circumstances. In this paper, a proposed control model of psoriasis is described on a given time interval by a nonlinear control system of three differential equations involving the concentrations of dendritic cells (tissues macrophages), T-lymphocytes, and keratinocytes with medication intake as a control function. An optimal control problem of minimizing the release of keratinocytes at the end of the time interval is stated and studied using the Pontryagin maximum principle. Different types of optimal control dependent on model parameters are obtained analytically. Possible applications to an optimal drug therapy are discussed.

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Medium-dose 308-nm excimer laser for the treatment of psoriasis

Cited by 78 publications

References 16 publications

Targeted phototherapy of plaque-type psoriasis using ultraviolet B-light-emitting diodes

Targeted phototherapy of plaque-type psoriasis using ultraviolet B-light-emitting diodes

S3‐Leitlinie zur Therapie der Psoriasis vulgaris Update 2011

Optimal Treatment Strategies for Control Model of Psoriasis

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