“…The immediate question to ask would be: Is it possible to formulate a projection operator P, which leads to the linear GLE (8) with the memory kernel K I (t)? A related question comprises the entropy production in such coarse-grained systems and whether it is possible to connect thermodynamic quantities such as entropy [37,38,50] as discussed intensively in the framework of stochastic thermodynamics [51][52][53] to dynamic coarse-graining, for example via projection operator techniques? We believe that answering these questions would pave the way towards systematic dynamic coarse-graining of non-equilibrium soft matter systems with applications to active microrheology [25,54], active matter [27,51,55], but also non-stationary situations such as crystallization [56], colloid self-assembly [57] or at phase transitions [58] using a non-stationary GLE [22,59].…”