Medium Optimization for Active Substance Production of <i>Streptomyces alboflavus</i> TD-1 Using Response Surface Methodology

Abstract

To increase the production of active substances, response surface methodology (RSM) was employed. The results showed that the inoculation size, concentrations of MgSO4•7H2O and KNO3 in medium had significant effects on yields of active substances and the final values optimized with RSM were 12.75 % inoculation size, 0.34 g/L MgSO4•7H2O and 0.13 g/L KNO3, respectively, which increased 1.96 fold production of active substances in comparison to the production of initial fermentation conditions.