Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway

Kwok, Carsten Tsun-Ka; Chow, Wang Ngai; Cheung, Kmc; Zhang, Xiaoyi; Mok, Daniel K. W.; Kwan, Yiu Wa; Chan, Gloria; Leung, George Pak-Heng; Cheung, Ka Wai; Lee, Simon Ming‐Yuen; Wang, Ning; Li, Jingjing; Seto, Sai Wang

doi:10.1007/s10787-023-01266-1

Cited by 2 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also inhibited the growth of S . aureus [ 15 ]. Treatments with a course of antibiotics are expensive, and overuse of antibiotics may increase the number of humans and animals infected by antibiotic-resistant bacteria [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it was shown that an aqueous extract of Medulla tetrapanacis possessed anti-inflammatory and bactericidal effects and prevented polarization of macrophages, which reduced the level of inflammatory mediators and phagocytosis inactivating the MAPK pathway. It also inhibited the growth of S. aureus [15]. Treatments with a course of antibiotics are expensive, and overuse of antibiotics may increase the number of humans and animals infected by antibiotic-resistant bacteria [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis

Gao,

Tang,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Objectives The goal of this investigation was to identify the main compounds and the pharmacological mechanism of the traditional Chinese medicine formulation, Gong Ying San (GYS), by infrared spectral absorption characteristics, metabolomics, network pharmacology, and molecular-docking analysis for mastitis. The antibacterial and antioxidant activities were determined in vitro. Methods The chemical constituents of GYS were detected by ultra-high-performance liquid chromatography Q-extractive mass spectrometry (UHPLC-QE-MS). Related compounds were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP, http://tcmspw.com/tcmsp.php) and the Encyclopedia of Traditional Chinese Medicine (ETCM, http://www.tcmip.cn/ETCM/index.php/Home/) databases; genes associated with mastitis were identified in DisGENT. A protein-protein interaction (PPI) network was generated using STRING. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment screening was conducted using the R module. Molecular-docking analyses were performed with the AutoDockTools V1.5.6. Results Fifty-four possible compounds in GYS with forty likely targets were found. The compound-target-network analysis showed that five of the ingredients, quercetin, luteolin, kaempferol, beta-sitosterol, and stigmasterol, had degree values >41.6, and the genes TNF, IL-6, IL-1β, ICAM1, CXCL8, CRP, IFNG, TP53, IL-2, and TGFB1 were core targets in the network. Enrichment analysis revealed that pathways associated with cancer, lipids, atherosclerosis, and PI3K-Akt signaling pathways may be critical in the pharmacology network. Molecular-docking data supported the hypothesis that quercetin and luteolin interacted well with TNF-α and IL-6. Conclusions An integrative investigation based on a bioinformatics-network topology provided new insights into the synergistic, multicomponent mechanisms of GYS’s anti-inflammatory, antibacterial, and antioxidant activities. It revealed novel possibilities for developing new combination medications for reducing mastitis and its complications.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis

Gao,

Tang,

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The stem pith of the plant, which is known as Medulla tetrapanacis (MT), is a traditional Chinese medicine called "da-tong-cao". It is considered helpful in promoting diuresis and alleviating edema and abdominal distention [6]. Moreover, MT also is a traditional resource for preparing painting paper, since it has a white color and reasonable luster.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Novel Lignocellulose-Based Aerogel by Partially Dissolving Medulla Tetrapanacis via Ionic Liquid

Quan,

Shi,

Zhang

et al. 2024

Gels

View full text Add to dashboard Cite

A novel lignocellulosic aerogel, MT-LCA, was successfully prepared from MT by undergoing partial dissolution in an ionic liquid, coagulation in water, freezing in liquid nitrogen, and subsequent freeze-drying. The MT-LCA preserves its original honeycomb-like porous structure, and the newly formed micropores contribute to increased porosity and specific surface area. FT-IR analysis reveals that MT, after dissolution and coagulation, experiences no chemical reactions. However, a change in the crystalline structure of cellulose is observed, transitioning from cellulose I to cellulose II. Both MT and MT-LCA demonstrate a quasi-second-order kinetic process during methylene blue adsorption, indicative of chemical adsorption. The Langmuir model proves to be more appropriate for characterizing the methylene blue adsorption process. Both adsorbents exhibit monolayer adsorption, and their effective adsorption sites are uniformly distributed. The higher porosity, nanoscale micropores, and larger pore size in MT-LCA enhance its capillary force, providing efficient directional transport performance. Consequently, the prepared MT-LCA displays exceptional compressive performance and efficient directional transport capabilities, making it well-suited for applications requiring high compressive performance and selective directional transport.

show abstract

Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway

Cited by 2 publications

References 32 publications

Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis

Evaluation of the mechanism of Gong Ying San activity on dairy cows mastitis by network pharmacology and metabolomics analysis

Preparation of a Novel Lignocellulose-Based Aerogel by Partially Dissolving Medulla Tetrapanacis via Ionic Liquid

Contact Info

Product

Resources

About