Medullary carcinoma with lymphoid infiltration of esophagus, report of a case.

Clinicopathologic and Molecular Profiles of Microsatellite Unstable Barrett Esophagus-associated Adenocarcinoma

“…Poorly differentiated carcinomas composed of sheets of epithelial cells with ill-formed glandular lumina, signet ring cell features, and mucinous (colloid) differentiation are uncommon, comprising 5% to 10% of cases. 26,29 Similarly, there are few cases of medullary 26,34 or lymphoepithelial 18,30 carcinoma of the esophagus in the literature, and to our knowledge, only a single case of BE-associated adenocarcinoma with lymphoid stroma (medullary carcinoma) has been reported so far. 35 Conversely, in this study, 4 of the 5 MSI-H tumors exhibited poor tumor differentiation, including medullary morphology, and the remaining case showed moderately differentiated adenocarcinoma with increased TILs.…”

CASE REPORT: A case of lymphoepithelioma‐like carcinoma of the oesophagus and review of the literature

“…There have only been 12 Japanese cases, inclusive of ours, reported in the literature to date 9 , 11–20 . All cases are summarized in Table 1.…”

“…There have only been 12 Japanese cases, inclusive of ours, reported in the literature to date. 9,[11][12][13][14][15][16][17][18][19][20] All cases are summarized in Table 1. In terms of age distribution (56-78 years; mean 69.2 years) and male:female ratio Occurrence sites of the reported LELC cases were mostly in the mid-thoracic portion (nine of 12 cases, 75%), which is similar to that of other oesophageal cancers, although gastric LELC are often in the upper portion of the stomach.…”

“…9 Molecular biological studies have detected Epstein-Barr virus in LELC cells in several organs in Oriental populations with particularly high frequency 5,7,10 and is strongly suspected to be associated with the carcinogenesis. To our knowledge, reported cases of oesophageal LELC are limited to Japan 9,[11][12][13][14][15][16][17][18][19][20] and there have been no reports of this disease in Western populations. The clinical and pathological features of with a central ulcer at 29 cm from the upper incisors ( Fig.…”