Medullary Raphe Neurons Facilitate Brown Adipose Tissue Activation

Nason, Malcolm W.; Mason, Peggy

doi:10.1523/jneurosci.4707-05.2006

Cited by 53 publications

(47 citation statements)

References 57 publications

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“…In contrast, cold-induced peripheral vasoconstrictor responses were normal. These observations are consistent with the conclusion that 5-HT neurons modulate descending synaptic drive from the hypothalamus to effector organs involved in thermogenesis, but are not part of the direct pathway for either heat generation or conservation (Nason and Mason, 2006).…”

Section: Integration Of Respiratory and Thermoregulatory Controlsupporting

confidence: 90%

“…Likewise, orexinergic neurons in the lateral hypothalamus are involved in feeding, arousal and ventilatory control, and are also CO 2 sensitive (Williams et al, 2007), and orexin-null mice exhibit a substantially blunted HCVR (Deng et al, 2007). Similarly, raphé 5-HT neurons respond to central (Nason and Mason, 2006) and peripheral (Martin-Cora et al, 2000) cooling and augment cold-induced thermogenesis, facilitate respiratory rhythm generation (Pena and Ramirez, 2002) and respiratory motor output (Brandes et al, 2006), and play a major role in ventilatory control during hypercapnia. These and other observations point to both the hypothalamus and 5-HT system as likely sites for integration of thermoregulatory, metabolic, and respiratory control, as previously suggested (Hinrichsen et al, 1998).…”

Section: Integration Of Respiratory and Thermoregulatory Controlmentioning

confidence: 99%

“…Each of these mechanisms are regulated at different levels of the CNS, and are influenced by 5-HT (Morrison, 2004b;Boulant, 2006;Dimicco and Zaretsky, 2007). Some 5-HT neurons project to the intermediolateral cell column (Cano et al, 2003), and increase their activity in response to both environmental (Martin-Cora et al, 2000) and hypothalamic (Nason and Mason, 2006) cooling. Additionally, systemic or raphé/parapyramidal application of the 5-HT 1A receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) decreases core temperature and impairs shivering (Hoffman et al, 2007), inhibits cold-induced vasoconstriction (Ootsuka and Blessing, 2003), and attenuates leptin-evoked activation of brown adipose tissue (BAT) sympathetic outflow (Morrison, 2004a).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, systemic or raphé/parapyramidal application of the 5-HT 1A receptor agonist 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) decreases core temperature and impairs shivering (Hoffman et al, 2007), inhibits cold-induced vasoconstriction (Ootsuka and Blessing, 2003), and attenuates leptin-evoked activation of brown adipose tissue (BAT) sympathetic outflow (Morrison, 2004a). However, it remains unclear if 5-HT neurons are presympathetic motor neurons that drive thermogenesis and peripheral vasoconstriction, or if they simply modulate descending drive (Nason and Mason, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

Hodges¹,

Tattersall²,

Harris³

et al. 2008

J. Neurosci.

294

348

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f/f/p mice was decreased by 50% compared with wild-type mice, whereas baseline ventilation and the hypoxic ventilatory response were normal. In addition, Lmx1b f/f/p mice rapidly became hypothermic when exposed to an ambient temperature of 4°C, decreasing core temperature to 30°C within 120 min. This failure of thermoregulation was caused by impaired shivering and nonshivering thermogenesis, whereas thermosensory perception and heat conservation were normal. Finally, intracerebroventricular infusion of 5-HT stimulated baseline ventilation, and rescued the blunted hypercapnic ventilatory response. These data identify a previously unrecognized role of 5-HT neurons in the CO 2 chemoreflex, whereby they enhance the response of the rest of the respiratory network to CO 2 . We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense.

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Section: Integration Of Respiratory and Thermoregulatory Controlsupporting

confidence: 90%

Section: Integration Of Respiratory and Thermoregulatory Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

Hodges¹,

Tattersall²,

Harris³

et al. 2008

J. Neurosci.

294

348

View full text Add to dashboard Cite

show abstract

“…CLP induced Fos in serotonergic cells. These neurons respond to preoptic cooling or intracerebroventricular administration of PGE 2 and fire at rates in direct proportion to the temperature of brown fat (Nason and Mason, 2006). However, both hyperthermia (Gourine et al, 1998) and hypothermia (Clemmer et al, 1992) can occur during the septic course, and glutaminergic cells in this same medullary area may also contribute to the control of core temperature (Nakamura et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Central neural distribution of immunoreactive Fos and CRH in relation to plasma ACTH and corticosterone during sepsis in the rat

Carlson

Chiu

Fiedler

et al. 2007

Experimental Neurology

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Although brain pathways activated by sepsis may respond acutely to endotoxin administration, the long-term central response to sepsis is not known. We prepared male rats for hormonal sampling at the circadian nadir (AM) and peak (PM) after cecal ligation and puncture (CLP) or sham surgery. Diurnal variation of corticosterone was present on postoperative day (D) 3 and D4 after sham surgery but not after CLP. CLP increased Fos immunostaining in the nucleus of tractus solitarius (NTS), ventrolateral medulla, medullary raphe, parabrachial nucleus, hypothalamus, amygdala, bed nucleus of stria terminalis, and preoptic region. Fos responses were generally greatest on D1 but persisted to the AM of D4. The number of Fos-positive cell nuclei in the NTS on D3 and D4 did not differ but had greater variance on D3 than on D4 (P < 0.01) with a divergent response in the PM of D3 that was correlated with plasma ACTH (r = 0.927, P<0.01) but not with corticosterone. CLP increased CRH-staining intensity in the hypothalamic paraventricular neurons uniformly from D1 through D4 (P<0.01). Similar to Fos in NTS, this response was correlated with plasma ACTH (r = 0.738, P<0.05) and adrenal size (r = 0.730, P<0.05) in the PM of D3. Neuronal CRH became detectable after CLP in specific medullary areas on D1 and in the preoptic region on D3 and D4. Thus, the suppression of circadian variation by CLP was associated with central neural responses that increased in relation to plasma ACTH without apparent influence on the release of corticosterone.

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Central Nervous System Regulation of Brown Adipose Tissue

Morrison

Madden

2014

Comprehensive Physiology

125

103

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Thermogenesis, the production of heat energy, in brown adipose tissue is a significant component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature in many species from mouse to man and plays a key role in elevating body temperature during the febrile response to infection. The sympathetic neural outflow determining brown adipose tissue (BAT) thermogenesis is regulated by neural networks in the CNS which increase BAT sympathetic nerve activity in response to cutaneous and deep body thermoreceptor signals. Many behavioral states, including wakefulness, immunologic responses, and stress, are characterized by elevations in core body temperature to which central command-driven BAT activation makes a significant contribution. Since energy consumption during BAT thermogenesis involves oxidation of lipid and glucose fuel molecules, the CNS network driving cold-defensive and behavioral state-related BAT activation is strongly influenced by signals reflecting the short and long-term availability of the fuel molecules essential for BAT metabolism and, in turn, the regulation of BAT thermogenesis in response to metabolic signals can contribute to energy balance, regulation of body adipose stores and glucose utilization. This review summarizes our understanding of the functional organization and neurochemical influences within the CNS networks that modulate the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolic alterations in BAT thermogenesis and BAT energy expenditure that contribute to overall energy homeostasis and the autonomic support of behavior.

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Medullary Raphe Neurons Facilitate Brown Adipose Tissue Activation

Cited by 53 publications

References 57 publications

Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

Central neural distribution of immunoreactive Fos and CRH in relation to plasma ACTH and corticosterone during sepsis in the rat

Central Nervous System Regulation of Brown Adipose Tissue

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