MEDULLOBLASTOMA IN A GRIZZLY BEAR (<i>URSUS ARCTOS HORRIBLIS</i>)

Mitchell, Jeffrey W.; Thomovsky, Stephanie A.; Chen, Annie V.; Layton, Arthur W.; Haldorson, Gary J.; Tucker, Russell L.; Roberts, Gregory

doi:10.1638/2014-0118.1

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…The most prevalent tumors are hepatic neoplasms (hepatocellular and biliary carcinoma) (VASHIST et al, 2013) and bone tumors, such as osteosarcoma, chondrosarcoma and osteoma (MURAKAMI et al, 2012), followed by lymphoma (BECK et al, 2016), mammary gland tumors and squamous cell carcinoma (VASHIST et al, 2013). Other types of neoplasms, such as thyroid cystadenoma, meduloblastoma, teratoma, ovarian carcinoma and meningioma, have been reported individually (STORMS et al, 2004;CHIEN et al, 2013;MUNK et al, 2013;MITCHELL et al, 2015;ROSSI et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Hohšteter¹,

Šoštarić-Zuckermann²,

Reljić³

et al. 2018

Vet. arhiv

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This article presents the first case of intestinal adenocarcinoma in a free living, culled 12 year old, European female brown bear (Ursus arctos), with its characteristic macropathological and histopathological manifestations. Necropsy revealed thoracic gunshot injuries (compassionate shot) and the poor physical condition of the animal, with body fat loss and musculature atrophy. An infiltrative mass protruded the jejunal wall with infiltration of the mesentery, visceral and parietal peritoneum, and distal parts of the colon and rectum. The histopathological examination presented an infiltrative, unencapsulated, moderately cellular neoplastic mass, composed of an epithelial cell population, forming irregular nests, papillary and ribbon like structures and small number of tubules, surrounded by an extensive desmoplastic reaction. Within the tumor a small number of cysts filled with mucin were noted. The epithelial neoplastic cells exhibited mild anisocytosis and anisokaryosis, and a low mitotic index. Histochemical Van Gieson staining showed strong positivity in the desmoplastic proliferation. The epithelial tumor cells were positively imunostained with cytokerain, and stromal cells with vimentin. The histological features presented are characteristic of intestinal adenocarcinomas, of the mixed tubular and mucinous type, with a prominent scirrous reaction.

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Section: Introductionmentioning

confidence: 99%

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Hohšteter¹,

Šoštarić-Zuckermann²,

Reljić³

et al. 2018

Vet. arhiv

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“…Streams of neoplastic cells with elongate cytoplasm and elongate dark nuclei with occasional pseudorosettes are hallmarks of CNS embryonal tumors in various animal species. 3,8,13,17,20,24,27 Based on the current WHO classification of tumors of the CNS and previous reports in the veterinary medical literature, a medulloblastoma was considered less likely given the supratentorial rather than cerebellar location of the neoplasm. 3,5,13,17,20,[22][23][24] The presence of rosettes is variable and not necessarily a feature of these tumors in veterinary species 3,5,8,17 ; rosettes were not present in our case.…”

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confidence: 99%

“…Medulloblastomas have been described in dogs, cattle, pigs, rats, and non-human primates, with single case reports in a cat, a grizzly bear, and a kowari. 1,4,9,11,16,18,19,25–28,31,32 These tumors affect young calves and adult individuals of other species, and occur mainly in the cerebellum. Other CNS embryonal tumors are exceedingly rare and have been described mainly in dogs, with fewer reports in cattle and a colobus monkey.…”

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confidence: 99%

Embryonal central nervous system tumor in the brain of a goose

et al. 2018

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Embryonal central nervous system (CNS) tumor is a rare malignant neoplasm that arises from the neural crest. Herein we describe an embryonal tumor in the brain of an adult male domestic goose ( Anser anser) that was euthanized after a short history of wandering and lethargy. Grossly, a focal, bright-red, soft plaque was present on the ventral aspect of the brain, extending from the optic chiasm to the midbrain, as well as into the dorsal neuroparenchyma. Histologically, the nodule consisted of a poorly demarcated population of neoplastic cells arranged in streams and bundles, and occasionally palisading around small capillaries (pseudorosettes). Neoplastic cells were elongate and had scant, finely granular, eosinophilic cytoplasm, and elongate nuclei with dense chromatin. Mitoses were uncommon. Scattered foci of intratumoral necrosis and microvascular proliferation were present. Neoplastic cells were immunoreactive for doublecortin and neuronal nuclei. Ultrastructurally, neoplastic cells had elongated-to-polyhedral cytoplasm with short processes, scarce intermediate filaments, and small round mitochondria and rough endoplasmic reticulum. The cell membrane had varied numbers of intercellular anchoring-like junctions, and nuclei were round-to-elongate and had marginal aggregates of heterochromatin. Morphologic, immunohistochemical, and ultrastructural findings in our case are consistent with a poorly differentiated embryonal tumor.

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LAPAROSCOPIC-ASSISTED INSERTION OF A VENTRICULOPERITONEAL SHUNT IN A RESCUED ASIATIC BLACK BEAR (URSUS THIBETANUS) IN LAOS

Pizzi¹,

Cracknell²,

Kitchener³

et al. 2017

Journal of Zoo and Wildlife Medicine

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A 3-yr-old Asiatic black bear (Ursus thibetanus), weighing 68 kg, underwent a laparoscopic-assisted placement of a ventriculoperitoneal shunt for hydrocephalus in the Lao People's Democratic Republic. Rescued as a young cub with a notably domed head, the bear's condition had deteriorated with age, but euthanasia was not a viable option because of cultural issues. Surgery was attempted as a palliative measure. The bear had ventrally orientated crossed eyes (abducens nerve palsy and dorsal midbrain syndrome), papilledema, severe rhinorrhea, depressed mentation, lethargy, a very poor appetite, and was stunted. Hydrocephalus was confirmed via intraoperative 2.0-5.0 MHz head ultrasound, as no magnetic resonance imaging was available in the country. Surgery was planned via 3D modeling of museum skulls and brain cavity, and ultrasound examination of formalin-preserved brains of other carnivores with hydrocephalus. The bear demonstrated a notable improvement in mentation, appetite, and behavior, maintained for 4 yr following surgery.

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MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS)

Cited by 5 publications

References 18 publications

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Embryonal central nervous system tumor in the brain of a goose

LAPAROSCOPIC-ASSISTED INSERTION OF A VENTRICULOPERITONEAL SHUNT IN A RESCUED ASIATIC BLACK BEAR (URSUS THIBETANUS) IN LAOS

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