2003
DOI: 10.1002/pbc.10401
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Medulloblastoma in childhood: Impact of radiation technique upon the outcome of treatment

Abstract: Our results are similar to those published in literature. M0-stage was the most powerful favourable prognostic factor. Male gender and neurological status before radiation treatment were associated with poor survival. Also protracted radiotherapy and quality of radiation technique may have an impact on the outcome.

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Cited by 21 publications
(19 citation statements)
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References 43 publications
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“…It is reasonable to assume that the olfactory nerve will be contained within a CTV that includes the cribiform plate, and this has already been discussed. 4,[19][20][21] We know that the optic nerves are surrounded by CSF to the back of the globe and that some RT planning techniques (tomotherapy) underdose this area unless it is specifically contoured as part of the CTV. 51 Neither our work nor the literature investigates whether there are meningeal reflections and CSF through the middle cranial fossa foramen, superior orbital fissure, ovale, rotundum and spinosum and this would be an interesting topic for further research.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is reasonable to assume that the olfactory nerve will be contained within a CTV that includes the cribiform plate, and this has already been discussed. 4,[19][20][21] We know that the optic nerves are surrounded by CSF to the back of the globe and that some RT planning techniques (tomotherapy) underdose this area unless it is specifically contoured as part of the CTV. 51 Neither our work nor the literature investigates whether there are meningeal reflections and CSF through the middle cranial fossa foramen, superior orbital fissure, ovale, rotundum and spinosum and this would be an interesting topic for further research.…”
Section: Discussionmentioning
confidence: 99%
“…Studies report the risk of cribiform plate recurrence in patients undergoing CSI in the era before this was considered to be part of the target volume, or when it was underdosed owing to either inadequate technique or deliberate shielding of the eyes. 4,[19][20][21] The same technical errors also resulted in recurrences inferiorly in the frontal and temporal lobes, 21 and there is now a general consensus that these structures should be included in the target volume however RT is planned and delivered.…”
Section: Clinical Settingmentioning
confidence: 99%
“…High-energy electrons for spine irradiation have been used since 1986 and this 2D technique and treatment results in 158 children with medulloblastoma were published previously. 11 In the next report we presented the outcome and patterns of failure for 95 patients with medulloblastoma treated with 3D-conformal radiotherapy. 12 New equipment installed in our department (accelerators with CBCT and TPS with forward IMRT planning) together with an increasing number of young children treated under anaesthesia led us to reconsider our technique of craniospinal irradiation.…”
Section: Introductionmentioning
confidence: 97%
“…[4][5][6] Long-term survivors experience a spectrum of radiation-related treatment effects including hearing loss, 7 endocrine deficiencies, 8 somatic effects, 9 cognitive decline, 10 cerebrovascular damage 11,12 and secondary malignancies. 13 Measures have been taken to lessen the effects of radiation therapy for patients who have favorable outcomes including those with average-risk MB 14 defined as no evidence of neuraxis dissemination, a minimal amount of residual tumor and no evidence of brainstem invasion or transtentorial extension from the primary site.…”
Section: Introductionmentioning
confidence: 99%