Medulloblastoma in Nordic Children. I

Clausen, Niels; Garwics, S.; Glomstein, Anders; Jónmundsson, Guđmundur; Kruus, S.; Yssing, M.

doi:10.1111/j.1651-2227.1990.tb17306.x

Cited by 8 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The typical lag time between symptom and diagnosis improved after the 1954 to 1964 period but has not changed since. In results similar to ours, Clausen et al (1990) found that diagnostic delay varied between 1 and 42 months with a median of 2 months. They also failed to find any relationship between the length of the diagnostic delay and subsequent survival.…”

Section: Incidencesupporting

confidence: 88%

“…It represents 8% of all solid tumours in children and 20% of CNS tumours of childhood (Blair and Birch 1994). The overall incidence rate of 4.5 cases per million child years is similar to that reported in studies from other areas in the UK (Stevens et al 1991, Thorne et al 1994) and other countries (Clausen et al 1990, Gjerris et al 1998.…”

Section: Incidencesupporting

confidence: 77%

“…Overall there has been a consistent increase in the rate of CNS tumours diagnosed in childhood in the UK (McNally et al 2001), Europe (Clausen et al 1990), and the USA (Gurney and Kadan-Lotick 2000). Two studies (Thorne et al 1994, Parkin et al 1988) have reported recent decreases in the incidence of childhood medulloblastoma in the UK.…”

Section: Incidencementioning

confidence: 96%

“…Several studies that start from the date of diagnosis and include all tumour-related deaths (Clausen et al 1990, Preston-Martin et al 1993, David et al 1997 found no difference in long-term survival rates between the sexes, although plots of the survival curves by sex were not given. This difference in short-term mortality between the sexes might point to differences either in response to treatment or in underlying tumour biology between males and females.…”

Section: Incidencementioning

confidence: 99%

See 3 more Smart Citations

Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival

Alston¹,

Newton²,

Kelsey³

et al. 2003

Dev Med Child Neurol

View full text Add to dashboard Cite

The incidence, survival patterns, and presenting symptoms of children with medulloblastoma were studied. Data were ascertained from the Manchester Tumour Registry which is population-based and has collected data on all childhood malignancies in northwest England since 1954. Incidence rates standardized to the European standard population were calculated and Poisson regression models were used to examine temporal changes in the incidence rates during the period 1954 to 1997. Kaplan-Meier survival curves were derived and used to study changes in survival patterns. World-standardized incidence rates were 5.5 per million child years in males and 3.4 per million child years in females. Incidence rates increased from the 1950s to the 1980s but have declined recently. The 5-year survival rate has improved from 29 to 58% with similar rates for males and females. The 1-year survival rate has also improved, but females had worse survival at this point (58%) than males (75%). The type of symptom or sign at presentation is strongly affected by age, with 10 of the 22 recorded symptoms or signs showing significant age differences. The older the child is, the more likely is the presentation to show pressure features of headache, vomiting, and ophthalmic signs. Younger children present with non-specific features such as lethargy, behavioural disturbance, or increasing head size. Ataxia is seen in about 75% of children across the age range.

show abstract

Section: Incidencesupporting

confidence: 88%

Section: Incidencesupporting

confidence: 77%

Section: Incidencementioning

confidence: 96%

Section: Incidencementioning

confidence: 99%

See 2 more Smart Citations

Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival

Alston¹,

Newton²,

Kelsey³

et al. 2003

Dev Med Child Neurol

View full text Add to dashboard Cite

show abstract

“…The follow-up study occurred in [1982][1983][1984][1985][1986]. Details have been given elsewhere (3,4).…”

Section: Methodsmentioning

confidence: 99%

Medulloblastoma in Nordic Children. III Long Term Growth and Endocrine Sequelae

et al. 1990

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Growth and endocrine status of 38 Nordic children surviving from medulloblastoma were reevaluated 5–15 years after the diagnosis. Group I included children treated before the age of 10, and group II were the patients > 10 years at onset of tumour therapy. The median time interval from diagnosis to reexamination was 9 and 7 8/12 years in groups I and II (p>0.1). The trunchal and standing height were highly affected at the follow‐up. The median standing height standard deviation score (SDS) was ‐2.0 in group I and ‐ 1.7 in group II. The corresponding median sitting height SDS was ‐2.5 in group I and +2.0 in group II. Growth hormone deficiency was found in 23 % of the patients, and only in group I. In both groups 69 96 had increased serum TSH concentrations (median 6.5 mU/I, range 1.3–30 mU/I) in spite of normal free T4 and total T3 levels. Hypogonadism and ACTH deficiency were rarely seen. Conclusion: In patients treated for medulloblastoma, particularly when treated in early childhood, pronounced alterations appear in growth and endocrine systems. In the general clinical control of these patients anthropometric and endocrinological tests have to be included.

show abstract

Embryonal Tumours

Berry¹,

Keeling²

1996

Paediatric Pathology

View full text Add to dashboard Cite

Medulloblastoma in Nordic Children. I

Cited by 8 publications

References 24 publications

Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival

Childhood medulloblastoma in northwest England 1954 to 1997: incidence and survival

Medulloblastoma in Nordic Children. III Long Term Growth and Endocrine Sequelae

Embryonal Tumours

Contact Info

Product

Resources

About