Meet the stripped down rat

Khamsi, Roxanne

doi:10.1038/435012a

Cited by 26 publications

(14 citation statements)

References 9 publications

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“…An important advancement in the field of drug screening is to integrate multiple miniaturized organ model systems into a single device to recapitulate the potential interaction between different organs in determining the drug’s ADME. The concept of microscale cell culture analog (μCCA) is a physical representation of PBPK model where different cell types are cultured in small chambers interconnected by fluidic channels [116]. Such systems offer versatile in vitro models to study drug’s biotransformation, and interaction between different tissues in determining drug’s response (both efficacy and toxicity).…”

Section: Microfabricated In Vitro Modelsmentioning

confidence: 99%

Microfabrication technologies for oral drug delivery

Sant

Tao

Fisher

et al. 2012

Advanced Drug Delivery Reviews

129

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Micro-/nanoscale technologies such as lithographic techniques and microfluidics offer promising avenues to revolutionalize the fields of tissue engineering, drug discovery, diagnostics and personalized medicine. Microfabrication techniques are being explored for drug delivery applications due to their ability to combine several features such as precise shape and size into a single drug delivery vehicle. They also offer to create unique asymmetrical features incorporated into single or multiple reservoir systems maximizing contact area with the intestinal lining. Combined with intelligent materials, such microfabricated platforms can be designed to be bioadhesive and stimuli-responsive. Apart from drug delivery devices, microfabrication technologies offer exciting opportunities to create biomimetic gastrointestinal tract models incorporating physiological cell types, flow patterns and brush-border like structures. Here we review the recent developments in this field with a focus on the applications of microfabrication in the development of oral drug delivery devices and biomimetic gastrointestinal tract models that can be used to evaluate the drug delivery efficacy.

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Section: Microfabricated In Vitro Modelsmentioning

confidence: 99%

Microfabrication technologies for oral drug delivery

Sant

Tao

Fisher

et al. 2012

Advanced Drug Delivery Reviews

129

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“…The microscale cell culture analog (lCCA), also known as a 'body-on-a-chip' or an 'animal-on-a-chip', was conceived as a physical realization of a PBPK model, as an in vitro system to emulate body's dynamic response to drugs [12]. Just like a PBPK model, compartments representing different organs are connected with fluidic channels mimicking blood circulation, and in each chamber the corresponding cell type is cultured.…”

Section: Microscale Cell Culture Analog (Lcca) Based On a Pbpk Modelmentioning

confidence: 99%

“…Such a device allows one to observe the systematic, whole-body response to drugs rather than the response of a single cell population. Furthermore, the recent advance in microfluidic systems has made it possible to precisely reproduce multi-organ interaction with blood circulation, which has been termed as a 'body-on-a-chip' approach [12]. Together with threedimensional cell cultures, such recent advances in microscale systems can contribute to developing a more realistic, in vitro system that can reproduce the whole-body response to drugs (Fig.…”

Section: Introductionmentioning

confidence: 99%

In vitro microscale systems for systematic drug toxicity study

Sung

Shuler

2009

Bioprocess Biosyst Eng

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After administration, drugs go through a complex, dynamic process of absorption, distribution, metabolism and excretion. The resulting time-dependent concentration, termed pharmacokinetics (PK), is critical to the pharmacological response from patients. An in vitro system that can test the dynamics of drug effects in a more systematic way would save time and costs in drug development. Integration of microfabrication and cell culture techniques has resulted in 'cells-on-a-chip' technology, which is showing promise for high-throughput drug screening in physiologically relevant manner. In this review, we summarize current research efforts which ultimately lead to in vitro systems for testing drug's effect in PK-based manner. In particular, we highlight the contribution of microscale systems towards this goal. We envision that the 'cells-on-a-chip' technology will serve as a valuable link between in vitro and in vivo studies, reducing the demand for animal studies, and making clinical trials more effective.

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“…Although much work has been done to develop culture models of single tissues, integration of multiple tissue models towards development of the so called 'human-ona-chip' is a relatively new concept [67]. In vivo, interactions between multiple organ systems are important for the maintenance of homeostasis, and such interactions can also mediate the toxicity of pharmaceuticals.…”

Section: Bioreactors For In Vitro Applicationsmentioning

confidence: 99%