The effect of increasing doses of mineral fertilizers on the formation and modification changes in the anatomical structures of vegetative bodies of rice under the conditions of the Kazakhstani Aral Sea region has been studied. With the application of an optimally high dose of mineral fertilizers, anatomical and morphophysiological characteristics and properties have been found that positively influence the formation of high yields: the number of small, external conducting beams increases, as well as the inner large conducting beams and their area; in the central vein of the leaves, the number of conducting beams increases, the leaf area and the number of photosynthetic mesophilic cells. This contributes to an increase in the yield of grain and its quality. Negative influence of high doses of fertilizers: small and large conductive bundles are located closer to the periphery of the stem, which leads to an expansion (to some extent) of the internal cavity of the stem. This increases (to a certain extent) the lodgingability of the rice stem.Keywords: Rice, fertilizers, the effect of increasing doses of mineral fertilizers on the anatomical structure of the stem, leaves, rice root.