Meeting the needs of long‐term survivors: A testament to success in the care of patients with cancer

Spiegel, Daphna Y.; Koontz, Bridget F.

doi:10.1002/cncr.31381

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Cancer and cancer treatment are associated with various physical and psychosocial problems, including difficulties with fatigue, declines in physical functioning, fear of cancer recurrence, anxiety, depression, cognitive limitations, coping issues, treatment-induced menopausal problems, and fertility problems, [ 1 – 4 ]. Although the majority of cancer survivors recover well, a significant number of them continue to have needs related to their disease and treatment [ 5 , 6 ]. Cancer survivors who report having more unmet information and support needs also have more symptoms of depression and anxiety and a lower quality of life [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

et al. 2022

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Background As the number of cancer survivors is growing, valid instruments for assessing cancer survivors' needs are required. Thus, the aim of this study was to translate and validate the Cancer Survivors Unmet Needs (CaSUN) scale. Methods Cancer survivors were recruited from 30 family medicine practices and separated into two samples (sample 1, n = 147; sample 2, n = 148). Factor structure was explored with an exploratory analysis in sample 1 and determined with a confirmatory analysis in sample 2. Psychometric properties were assessed with internal consistency, test–retest reliability and construct validity. Results A translation and cultural adaptation of the CaSUN scale resulted in 34 items being included in the final version. The factor structure confirmed the five-factors solution of the CaSUN-SL. Cronbach’s alpha was 0.94 for the CaSUN-SL and ranged from 0.71–0.88 for specific domains. Test–retest reliability showed moderate-high stability over time. The CaSUN-SL significantly and positively correlated with anxiety (r = 0.49), depression (r = 0.44), health-related quality of life (r = 0.36), and negatively with self-perceived health (r = − 0.36) and resilience (r = − 0.47), which confirms the construct validity. In addition, we found a significant correlation between unmet needs and age (r = − 0.29), gender (r = 0.14), cancer stage (r = 0.20), cancer type (r = 0.19), and time since treatment (r = − 0.20). Conclusions Results indicate that CaSUN-SL is a valid and reliable measure to assess the Slovenian cancer survivors’ unmet, met and total needs and can be used for further prospective studies. Trial Registration: No. 0120-25/2019/6.

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Section: Introductionmentioning

confidence: 99%

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Cancer and cancer treatment are associated with various physical and psychosocial problems, including difficulties with fatigue, declines in physical functioning, fear of cancer recurrence, anxiety, depression, cognitive limitations, coping issues, treatment-induced menopausal problems, and fertility problems, [1][2][3][4]. Although the majority of cancer survivors recover well, a significant number of them continue to have needs related to their disease and treatment [5,6]. Cancer survivors who report having more unmet information and support needs also have more symptoms of depression and anxiety and a lower quality of life [7,8].…”

Section: Introductionmentioning

confidence: 99%

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

Miroševič

Zupančič

Prins

et al. 2022

Preprint

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Background As the number of cancer survivors is growing, valid instruments for assessing cancer survivors' needs are required. Thus, the aim of this study was to translate and validate the Cancer Survivors Unmet Needs (CaSUN) scale. Methods Cancer survivors were recruited from 30 family medicine practices and separated into two samples (sample 1, n = 147; sample 2, n = 148). Factor structure was explored with an exploratory analysis in sample 1 and determined with a confirmatory analysis in sample 2. Psychometric properties were assessed with internal consistency, test-retest reliability and construct validity. Results A translation and cultural adaptation of the CaSUN scale resulted in 34 items being included in the final version. The factor structure confirmed the five-factors solution of the CaSUN-SL. Cronbach’s alpha was 0.94 for the CaSUN-SL and ranged from 0.71–0.88 for specific domains. Test-retest reliability showed moderate-high stability over time. The CaSUN-SL significantly and positively correlated with anxiety (r = 0.49), depression (r = 0.44), health-related quality of life (r = 0.36), and negatively with self-perceived health (r = -0.36) and resilience (r = -0.47), which confirms the construct validity. In addition, we found a significant correlation between unmet needs and age (r = -0.29), gender (r = 0.14), cancer stage (r = 0.20), cancer type (r = 0.19), and time since treatment (r = -0.20). Conclusions Results indicate that CaSUN-SL is a valid and reliable measure to assess the Slovenian cancer survivors’ unmet, met and total needs and can be used for further prospective studies. Trial Registration: no. 0120 − 25/2019/6

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“…As one of the most common malignant tumors among women, breast cancer is the second and common cause of cancer-related death in women (Wood et al, 2017; Bray et al, 2018). Chemotherapy has become one of the most mature and common treatment option for breast cancer (Fisher et al, 1998; Miller et al, 2016; Spiegel and Koontz, 2018). Doxorubicin (DOX) is an anthracycline non-specific broad-spectrum anticancer drug that is widely used to treat breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy

et al. 2019

Front. Pharmacol.

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Combination therapy which enhances efficacy and reduces toxicity, has been increasingly applied as a promising strategy for cancer therapy. Here, a reactive oxygen species (ROS) that enhanced combination chemotherapy nanodevices was fabricated based on the Fe-chelated polydopamine (PDA) nanoparticles (NPs). The structure was characterized by dynamic light scattering-autosizer, transmission electron microscopy, energy dispersive spectroscopy, and Fourier-transform infrared (FT-IR) spectrophotometer. The in vitro drug release profile triggered by low intracellular pH indicated that the system demonstrated controlled therapeutic activity. In vitro cell uptake studies showed that doxorubicin (DOX)-loaded Fe-PDA/ folic acid (FA)- polyethylene glycol (DOX@Fe-PDA/FA-PEG) had a strong uptake capacity and can be rapidly internalized by MCF-7 cells. The in vitro experiments demonstrated that DOX@Fe-PDA/FA-PEG triggered the intracellular ROS overproduction, thereby enhancing its therapeutic effect on breast cancer. In summary, this experiment demonstrated the novel DOX-loaded composite NPs used as a potential targeted nanocarrier for breast cancer treatment, which could be a promising therapeutic strategy against breast cancer.

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Meeting the needs of long‐term survivors: A testament to success in the care of patients with cancer

Cited by 3 publications

References 17 publications

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

Psychometric properties of the Slovenian version of the Cancer Survivors’ Unmet Needs (CaSUN-SL) measure in post-treatment cancer survivors

Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy

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