MEG in Epilepsy and Pre-surgical Functional Mapping

Iwasaki, Masaki; Nakasato, Nobukazu

doi:10.1007/978-3-030-00087-5_39

Cited by 2 publications

(1 citation statement)

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“…Magnetoencephalography (MEG) signals are derived from the net effect of postsynaptic ionic currents that flow in the dendrites of neurons under synaptic transmission and are generated by a substantial population of neurons aligned in the same direction. 19 , 20 Compared with EEG signals, MEG signals are less influenced by the difference in electrical conductivities between the CSF, skull and skin, as these tissues that surround the brain have constant magnetic permeability. 21 Thus, MEG is a non-invasive modality that estimates the source of interictal epileptiform discharges (IEDs).…”

Section: Introductionmentioning

confidence: 99%

Epileptic discharges initiate from brain areas with elevated accumulation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors

Miyazaki

Takayama

Iwasaki

et al. 2022

Brain Communications

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Presurgical identification of the epileptogenic zone is a critical determinant of seizure control following surgical resection in epilepsy. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a major component of neurotransmission. Although elevated AMPAR levels are observed in surgically resected brain areas of patients with epilepsy, it remains unclear whether increased AMPAR-mediated currents initiate epileptic discharges. We have recently developed the first positron emission tomography (PET) tracer for AMPAR, [11C]K-2, to visualize and quantify the density of AMPARs in living human brains. Here, we detected elevated [11C]K-2 uptake in the epileptogenic temporal lobe of patients with mesial temporal lobe epilepsy. Brain areas with high [11C]K-2 uptake are closely colocalized with the location of equivalent current dipoles estimated by magnetoencephalography or with seizure onset zones detected by intracranial electroencephalogram. These results suggest that epileptic discharges initiate from brain areas with increased AMPARs, providing a biological basis for epileptic discharges and an additional non-invasive option to identify the epileptogenic zone in patients with mesial temporal lobe epilepsy.

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Section: Introductionmentioning

confidence: 99%