Meg Recordings of Patients With CNS Disorders Before and After External Magnetic Stimulation

Anninos, P. A.; Kotini, A; Anninou, Nicolia; Adamopoulos, Adam; Papastergiou, A; Tsagas, N.

doi:10.1142/s0219635208001745

Cited by 14 publications

(14 citation statements)

References 22 publications

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“…We took the clinical model to be a 2 Hz frequency increase based on previous work showing a (2–7 Hz) frequency change of greater than 2 and less than 6 Hz (Anninos et al 1991, 2000, 2006, 2007, 2008, O’Clock 2003). We compared this to a null model in which the frequency change was 0 Hz.…”

Section: Resultsmentioning

confidence: 99%

“…The aim is to use very sensitive methods to identify any change in brain state consistent with our predictions that the pT helmet should increase the peak frequency within the 2–7 Hz band towards frequencies of less or equal to those frequencies of the alpha frequency range (8–13 Hz) for each individual subject (Anninos et al 1991, 2000, 2006, 2007, 2008). …”

Section: Introductionmentioning

confidence: 84%

“…In this study we set out to replicate the effects of increased cortical endogenous frequencies in the 2–7 Hz band due to the effect of pT stimulation (Anninos et al 1991, 2000, 2006, 2007, 2008) in a group of healthy controls. We used a state-of-the-art head-cast design to ensure that the MEG measurements were of the highest possible precision.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, the electronic device invented by (Anninos and Tsagas 1995) is thought to increase the frequencies of endogenous brain activity of the (2–7 Hz) range towards frequencies of less than or equal to those frequencies of the alpha frequency range (8–13 Hz) of each individual subject (Anninos et al 2008). One possible electrophysiological explanation for the efficacy of pico-Tesla-magnetic-stimulation (pTMS) has been provided by the proposed ‘neural net model’ (Anninos et al 1989) which suggests that magnetic stimulation causes a temporally modulated neuronal inhibition in regions exhibiting abnormal activity in the frequency range of 2–7 Hz.…”

Section: Introductionmentioning

confidence: 99%

“…This hypothesis is in concordance with data presented by other investigators (John 1967, Kaczmarek and Adey 1974, Ossenkopp and Cain 1988). Clinically, this technique is now regularly used in the Government General University Hospital, Laboratory of Medical Physics in the School of Medicine of DUTH University in Greece (Anninos et al 1991, 2000, 2006, 2007, 2008). All patients treated in the above references were referred from neurologists from other hospitals or neurology clinics in Greece.…”

Section: Introductionmentioning

confidence: 99%

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Neuromagnetic effects of pico-Tesla stimulation

2015

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We used a double-blind experimental design to look for an effect of pico-Tesla magnetic stimulation in healthy subjects. Pico-Tesla stimulation is thought to increase the dominant frequency of 2–7 Hz oscillations in the human brain. We used magnetoencephalography to measure resting state brain activity. Each subject had two separate recording sessions consisting of three runs in between which they were given real or sham pT stimulation. We then tried to predict the real and sham stimulation sessions based on changes in the mean peak frequency in the 2–7 Hz band. Our predictions for these individual runs were 8 out of 14 at chance level (p = 0.39). After unblinding, we found no significant effect (p = 0.11) of an increase in the frequency range (2–7 Hz) across the subject group. Finally, we performed a Bayesian model comparison between the effect size predicted from previous clinical studies and a null model. Even though this study had a sensitivity advantage of at least one order of magnitude over previous work, we found the null model to be significantly (2000 times) more likely.

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