Mega Cisterna Magna Associated with Recurrent Catatonia: A Case Report

Kumar, Sudhir; Sur, Shravani; Singh, Ashutosh Kumar

doi:10.1016/j.biopsych.2011.04.015

Cited by 13 publications

(14 citation statements)

References 7 publications

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“…Psychotic cases were generally associated with Dandy-Walker syndrome, MCM, or DWV. Other psychiatric disorders associated with posterior fossa abnormalities include obsessive-compulsive disorder [33, 39, 50], posttraumatic stress disorder [47], attention deficit hyperkinetic disorders [51, 52], manic episodes [38, 53, 54], bipolar disorder [55-59], impulsive behavior associated with recurrent major depression [60], or recurrent catatonia [38, 61]. …”

Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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Introduction: Dandy-Walker malformation is a rare congenital malformation involving cystic dilatation of the fourth ventricle, enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis, elevated tentorium cerebelli, and hydrocephalus. Previous research highlighted a possible role for the cerebellum in schizophrenia as well as the contribution of underlying brain malformations to treatment resistance. Here, we present a case of a Dandy-Walker malformation-like condition revealed by a refractory schizophrenia in a 24-year-old male patient. We also conduct a literature review of all previously published case reports or case series of co-occurring posterior fossa abnormalities and schizophrenia or psychosis using a PubMed search query to better understand the potential link between these two disorders. Case Presentation: A 9-month hospital stay was needed to address the treatment-resistant psychotic symptoms, and the patient continued to experience moderate symptoms despite the prescription of various antipsychotic and antidepressant medications. After an irregular initial medical follow-up, the patient is currently treated with 350 mg daily clozapine and 20 mg daily prazepam and still exhibits moderate anxiety without delirious thoughts, however allowing him to re-enroll at the university. Regarding the literature, 24 cases published between 1996 and 2017 were identified, reviewed and compared to the present case report. Discussion: This case report and literature review further illuminates the pathophysiology of psychotic disorders including the potential role of the cerebellum, reinforces the importance of a multidisciplinary approach for the neurological and psychiatric management of patients with schizophrenia, and highlights optimal pharmacological management strategies for treatment-resistant schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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“…2 Occasionally, psychotic symptoms and other psychiatric disorders have been reported to occur in patients with DWS. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, the prevalence and clinical features of this comorbidity have not been established yet, and the literature about the topic is scarce. This is not the only neurological condition that presents with psychiatric comorbidities: several brain alterations, both structural and pathophysiological, can result in psychiatric symptoms.…”

Section: Introductionmentioning

confidence: 99%

Psychosis and Dandy-Walker syndrome: a case report and review of the literature

et al. 2021

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Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.

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“…There is genetic evidence that MLC1 polymorphisms are specifically associated with periodic catatonia, a variety of chronic catatonia [14]. In a patient with recurrent episodes of catatonia lasting two to three months, a magnetic resonance imaging scan revealed mega cisterna magna that was mildly and diffusely compressing the left cerebellum and causing pressure scalloping of the internal table of the skull vault in the left occipital region [15]. These findings suggest that future studies should explore the concept of recurrent catatonia.…”

Section: Discussionmentioning

confidence: 99%

Chronic catatonia treated with electroconvulsive therapy: a case report

et al. 2013

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IntroductionIn the International Statistical Classification of Diseases and Related Health Problems 10 and Diagnostic and Statistical Manual of Mental Disorders IV classification systems, catatonia is classified as a subtype of schizophrenia. However, catatonia is more frequently associated with mood disorders than schizophrenia. It is also associated with organic conditions. Catatonia responds to treatment with benzodiazepines and electroconvulsive therapy rather than antipsychotics. These features support the categorization of catatonia as an independent syndrome. There is a lack of consensus regarding the definition of chronic catatonia. There are two previous case reports of effective treatment of chronic catatonia with electroconvulsive therapy.Case presentationA 29-year-old South Asian woman was admitted to hospital because of poor food intake. Her condition had progressively worsened over the past seven months. She had features of catatonia. On admission, her Bush-Francis Catatonia Rating Scale score was 24. Her symptoms resolved after the administration of 17 electroconvulsive therapies but recurred later. She was given a further four electroconvulsive therapies. She remains well on aripiprazole at a dose of 60mg a day.ConclusionsBilateral electroconvulsive therapy is effective in the treatment of chronic catatonia and should be considered as a treatment option. A relapse of symptoms can occur after the discontinuation of treatment.

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Mega Cisterna Magna Associated with Recurrent Catatonia: A Case Report

Cited by 13 publications

References 7 publications

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Psychosis and Dandy-Walker syndrome: a case report and review of the literature

Chronic catatonia treated with electroconvulsive therapy: a case report

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