Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation

Noh, K.M.; Lim, Ho-Kyung; Moon, Sung Kyu; Kang, Jae Seung; Lee, Wang Jae; Lee, Dong Sup; Hwang, Yu-Jin

doi:10.1016/j.imlet.2004.10.012

Cited by 46 publications

(44 citation statements)

References 41 publications

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“…Similar results were obtained in young people after 3 weeks of oral mega-dose vitamin C ingestion (Anderson et al, 1980). T cells from mice that were treated with vitamin C during antigen challenge (dinitrofluorobenzene, to elicit a delayed-type hypersensitivity response) showed enhanced in vitro proliferative (Noh et al, 2005). Interestingly, the cytokine secretion profiles of these T cells showed skewed polarization toward Th1.…”

Section: Introductionsupporting

confidence: 78%

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Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects

et al. 2009

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Section: Introductionsupporting

confidence: 78%

“…In our previous report (Noh et al, 2005), in vivo administration of mega-dose vitamin C induced a shift to a Th1 cytokine secretion profile in T cells. Another group reported a similar Th1 shift for another antioxidant.…”

Section: Article In Pressmentioning

confidence: 77%

Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects

et al. 2009

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“…Being a potent antioxidant [37,46] and cofactor of many enzymes, AA takes part in such vital physiological processes as hormone production, collagen synthesis [6], stimu lation of the immune system [16,45,63], etc. The long-term lack of vitamin C leads to scurvy, a pathological process caused prima rily by a violation of collagen production and manifested in the destruction of blood vessels, disorders in the formation of bone tissue and attachment of the periosteum to the bones as well as loosening of teeth [21,40].…”

mentioning

confidence: 99%

Protective Activity of Ascorbic Acid at Influenza Infection

Zarubaev

Slita

Lavrentyeva

et al. 2018

Russian Journal of Infection and Immunity

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Abstract. Ascorbic acid (vitamin C, AA) is an essential nutrient of the human diet due to its participation on numerous regulatory and enzymatic processes. AA takes part in such vital physiological processes as hormone production, collagen synthesis, stimulation of the immune system, etc. In the present review the activities of AA are considered that provide its protective effect at influenza infection. This effect can be result of direct virus-inhibiting activity of AA as well as of anti-inflammatory and antioxidant properties. Oxidative stress during influenza infection leads to nonspecific damage of the pulmonary tissue and subsequent inflammation of the lungs. The antioxidant activity of AA results in alleviation of infection due to suppression of tissue damage as well as in inhibition of reactive oxygen species-mediated signal transduction and regulatory reactions. After oxidation by ROS, AA is converted to dehydroascorbic acid (DAA) and inhibits the key enzymes of NF-κB pathway, such as kinases IKKα and IKKβ. AA itself blocks the activity of another component of the NF-kB pathway, kinase IKKβ(SS/EE), whose activity is directed to the phosphorylation of the factor IκBα. As a result, activation of NF-κB and its transport to the nucleus does not occur. Thus, AA performs a dual function: first, it neutralizes free radicals, preventing them from activating NF-κB, and secondly, the product of its oxidation, DAA, further blocks the activation of this pathway. In addition, in some cases AA results in the decrease in the infectious activity of influenza virus that is not due to the antioxidant activity of AA, but to direct virus-inhibiting activity. Taken together, the presented data suggests that the use of drugs with antiviral and antioxidant activity, as a combination of individual drugs or, as in the case of AA, as a single drug with complex activity, for treatment of influenza has advantages over the etiotropic drug monotherapy scheme. Резюме. Аскорбиновая кислота (витамин C, АК) является важным пищевым компонентом для человека благо-даря ее роли в различных регуляторных и ферментативных процессах. АК принимает участие в таких жизненно важных физиологических процессах, как продукция гормонов, синтез коллагена, стимуляция иммунной си-стемы и пр. В настоящем обзоре рассмотрена активность АК, обеспечивающая ее протективный эффект при гриппозной инфекции. Этот эффект может быть обусловлен прямой вирусингибирующей активностью АК, а также ее противовоспалительными и антиоксидантными свойствами. Окислительный стресс при гриппе ведет к неспецифическому повреждению ткани легких и развитию воспаления. Антиоксидантная активность АК приводит к облегчению течения инфекции вследствие снижения уровня повреждения ткани и ингибиро-

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“…The present study demonstrates insufficient intake of vitamin C (65 % of RDA for the entire study group). Deficiency of ascorbic acid may impair the process of T lymphocyte proliferation and cytotoxicity of neutrophils and Tc lymphocytes; the effects revert to normal with the correction of insufficient intake of vitamin C (Noh et al 2005). We also found a lower than recommended intake of vitamin E by the participants of the study.…”

Section: Discussionmentioning

confidence: 50%

Nutrition and Immune System in Children with Simple Obesity

Czerwonogrodzka–Senczyna

Janusz

Jeznach-Steinhagen

et al. 2015

Advances in Experimental Medicine and Biology

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The purpose of this study was to evaluate dietary factors in nutrition influencing the immune system of children and teenagers suffering from simple obesity. The study involved 100 children and teenagers aged 7-18 with simple obesity. Nutritional data were obtained from 3-day food records. The consumed nutrients, including immunomodulators and immunostimulants, were estimated based on the nutrition interview. The results were compared with the nutritional norms. On average, the proportion of n-6:n-3 fatty acids equalled 10:1. Among the amino acids, the highest intake values in the diet were observed for glutamine (13,694.6 mg/day). The study demonstrates inadequate intake levels of iron (73% of recommended dietary allowance, RDA), vitamin C (65% of RDA), and vitamin D (11% of RDA) taking into account the median values for the entire study group. The median daily intake of other nutrients exceeded the RDA values. The diets of the participants in this study were not properly balanced with respect to immunomodulators, which may contribute to the occurrence of immunological disorders and immunodeficiency in this group of patients.

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Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation

Cited by 46 publications

References 41 publications

Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects

Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects

Protective Activity of Ascorbic Acid at Influenza Infection

Nutrition and Immune System in Children with Simple Obesity

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